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Physico-chemical Properties of Supramolecular Complexes of Natural Flavonoids with Biomacromolecules

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Nanomaterials and Supramolecular Structures

Abstract

Polyvinylpyrrolidone (a water-soluble biopolymer) and human serum albumin (a globular protein) form supramolecular complexes with natural flavonoids quercetin and rutin in aqueous medium. The interaction with these biomacromolecules (BMM) causes the alteration of flavonoid spectral, protolytic, and other properties; in particular, it essentially increases their solubility. Absorption and solubility measurements revealed the supramolecular compounds of 1:1 stoichiometry for all systems studied. First it was demonstrated experimentally that the interaction with BMM promotes the tautomeric transformation in quercetin molecule. The mechanism of tautomerization via flavonoid molecular structure was discussed. Adsorption of BMM and their supramolecular compounds with flavonoids onto nanosilica was studied as a function of pH, and the properties of the biomacromolecules, flavonoids, and silica surface. It was found that BMM either complexed with quercetin (rutin) or preliminary immobilized on nanosilica increases the flavonoid adsorption.

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Acknowledgements

This research was supported by STCU (Grant 3832)

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Authors and Affiliations

  1. O.O. Chuiko Institute of Surface Chemistry of the National Academy of Sciences of Ukraine, General Naumov St. 17, 03164, Kyiv, Ukraine

    V.M. Barvinchenko, N. O. Lipkovska, T.V. Fedyanina & V.K. Pogorelyi

Authors
  1. V.M. Barvinchenko
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  2. N. O. Lipkovska
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  3. T.V. Fedyanina
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  4. V.K. Pogorelyi
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Corresponding author

Correspondence to N. O. Lipkovska .

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Editors and Affiliations

  1. G.V. Kurdiumov Inst. Metal Physics, National Academy of Sciences of Ukraine, Blvd. Akademika Vernadskogo 36, Kiev, 03680, Ukraine

    Anatoliy Petrovych Shpak

  2. A. A. Chuiko Inst. Surface Chemistry, National Academy of Sciences of Ukraine, General Naumov St. 17, Kiev, 03164, Ukraine

    Petr Petrovych Gorbyk

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Barvinchenko, V., Lipkovska, N.O., Fedyanina, T., Pogorelyi, V. (2009). Physico-chemical Properties of Supramolecular Complexes of Natural Flavonoids with Biomacromolecules. In: Shpak, A., Gorbyk, P. (eds) Nanomaterials and Supramolecular Structures. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2309-4_23

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