Abstract
There are a range of treatment options for men with PE, directed at different components of the complex mechanism of the ejaculatory process. These include behavioral therapy, systemic treatments, and topical therapies. However, there are currently no pharmacological agents approved for use in PE, and all drugs have to be administered off-label.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Montague D, Jarrow J, Broderick GA et al (2004) The AUA erectile dysfunction guideline update panel. AUA guideline on the pharmacologic management of premature ejaculation. J Urol 172:290–294
McMahon CG, Abdo C, lncrocci L, et al (2004) Disorders of orgasm and ejaculation in men. In: Lue TF, Basson R, Rosen R, et al (eds) Sexual medicine: sexual dysfunctions in men and women. 21st edn, Paris, 411–68
Hellstrom W (2006) Current and future pharmacotherapies of premature ejaculation. J Sex Med 3(Suppl 4):332–341
Montorsi F, Gauzzione G, Trimbolie F, et al (1995) Clomipramine for premature ejaculation: a ramdomized, double-blind, placebo controlled study. Acta Urol ltal 1: S-6
Girgis S (1982) EI-Haggar S, EI-Hermouzy S. A double-blind trial of clomipramine in premature ejaculation. Andrologia 14:364–369
Sharlip ID (2006) Guidelines for the diagnosis and management of premature ejaculation. J Sex Med 3(suppl 4):309–317
Pryor J, Althof S, Steidle C, Miloslavsky M (2005) Efficacy and tolerability of dapoxetine in the treatment of premature ejaculation. J Urol 173:201
Rowland DL, Haensel SM, Blom JH, Slob AK (1993) Penile sensitivity in men with premature ejaculation and erectile dysfunction. J Sex Marital Ther 19:189–197
Xin ZC, Chung WS, Choi YO et al (1996) Penile sensitivity in patients with primary premature ejaculation. J Urol 156:979–981
Wyllie MG, Hellstrom WJ (2011) The link between penile hypersensitivity and premature ejaculation. BJU Int 107:452–457
Schapiro B (1943) Premature ejaculation: a review of 1130 cases. J Urol 3:374–379
Xin ZC, Choi YO, Lee WH et al (1998) Changes in ejaculatory latency and penile vibratory threshold with SS-cream in patients with primary premature ejaculation. Sex Dyfunction 1:89–93
Xin ZC, Choi YO, LEE SH, Choi HK (1997) Efficacy of a topical agent SS-cream in the treatment of premature ejaculation: preliminary clinical studies. Yonsei Med J 38:91–95
Choi HK, jung GW, Moon KH et al (2005) Clinical study of SS-cream in patients with lifelong premature ejaculation. Urology 55:257–261
Tian L, Xin ZC, Xin H et al (2004) Effect of renewed SS-cream on spinal somatosensory evoked potentials in rabbits. Asian J Androl 6:15–18
Lee TY, Lam TH (1988) Irritant contact dermatitis due to a Chinese herbal medicine lu-shen-wan. Contact Dermatitis 18:213–218
Berkovitch M, Kerestechi AG, Koren G (1995) Efficacy of prilocaine-lidocaine cream in the treatment of premature ejaculation. J Urol 154:1360–1361
Atikeler MK, Gecit I, Senol FA (2002) Optimum usage of prilocaine-lidocaine cream in premature ejaculation. Androlog 34:356–359
Busato W, Galindo CC (2004) Topical anesthetic use for treating premature ejaculation: a double-blind, randomized, placebo-controlled study. BJU lnt 93:1018–1021
Gittleman MC, Mo J, Lu M (2006) Synergistic effect of meatal application on dyclonine/alprostadil cream for the treatment of early ejaculation in a double-blind crossover study. J Sex Med 3(Supp 3):176
Henry R, Morales A (2003) Topical lidocaine-prilocaine spray for the treatment of premature ejaculation: a proof of concept study. lnt J Imp Res 15:277–81
Dinsmore WW, Hackett G, Goldmeier D et al (2007) Topical eutectic mixture for premature ejaculation (TEMPE): a novel aerosol-delivery form of lidocaine-prilocaine for treating premature ejaculation. BJU lnt 99:369–375
Dinsmore WW, Wyllie MG (2009) PSD502 improves ejaculatory latency, control and sexual satisfaction when applied topically 5 min before intercourse in men with premature ejaculation: results of a phase III multi-centre, double-blind, placebo-controlled study. BJU Int 103:940–949
Carson C, Wyllie MG (2010) Improved ejaculatory latency, control and sexual satisfaction when PSD502 is applied topically in men with premature ejaculation: results of a phase III, double-blind, placebo-controlled study. J Sex Med 9:3179–3189
McMahon CG, Althof S, Waldinger MD et al (2008) An evidence-based definition of lifetime premature ejaculation: report of the international society of sexual medicine ad hoc committee for the definition of premature ejaculation. BJU Int 102:338–350
Waldinger MD (2003) Towards evidence-based drug treatment research on premature ejaculation: a critical evaluation of methodology. Int J Imp Res 15:309–313
Hirsch M, Donatucci C, Glina S et al (2004) Standards for clinical trials in male sexual dysfunction: erectile dysfunction and rapid ejaculation. J Sex Med 1:87–91
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag Italia
About this chapter
Cite this chapter
Dinsmore, W., McCarty, E. (2013). Use of Local Anesthetics in the Treatment of Premature Ejaculation. In: Jannini, E., McMahon, C., Waldinger, M. (eds) Premature Ejaculation. Springer, Milano. https://doi.org/10.1007/978-88-470-2646-9_21
Download citation
DOI: https://doi.org/10.1007/978-88-470-2646-9_21
Published:
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-2645-2
Online ISBN: 978-88-470-2646-9
eBook Packages: MedicineMedicine (R0)