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The Endothelium: A New Secretory Organ Target or Promoter of Pathophysiological Derangements in ICU Patients

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Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.

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Abstract

The vascular endothelium constitutes an interface between the blood and the rest of the tissues. It occupies a good strategic position for fulfilling its metabolic and endocrine functions. The former include removal and inactivation of biogenic amines, nucleotides, eicosanoids, lipoproteins, kinins or conversion of angiotensin I to angiotensin II, whereas the secretory activities comprise generation of prostacyclin (PGI2), nitric oxide (NO), endothelins (ET 1-3), plasminogen activators (t-PA), plasminogen activator inhibitor (PAI-1), thrombomodulin (TRM), platelet-derived growth factor ß (PDGF-ß), von-Willebrandt factor (v-WF), vascular cell adhesion molecule-1 (VCAM-1) and many others.

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Authors
  1. R. J. Gryglewski
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Editors and Affiliations

  1. Department of Anaesthesiology and Intensive Care, Trieste University School of Medicine, Trieste, Italy

    Antonino Gullo M.D. (Head) (Head)

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© 1996 Springer-Verlag Italia, Milano

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Gryglewski, R.J. (1996). The Endothelium: A New Secretory Organ Target or Promoter of Pathophysiological Derangements in ICU Patients. In: Gullo, A. (eds) Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.. Springer, Milano. https://doi.org/10.1007/978-88-470-2203-4_16

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  • DOI: https://doi.org/10.1007/978-88-470-2203-4_16

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-3-540-75014-7

  • Online ISBN: 978-88-470-2203-4

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