Riassunto
La PET è una tecnica medico-nucleare di imaging funzionale utilizzata per l’inquadramento diagnostico e prognostico del paziente neoplastico. Tale metodica consente di ottenere informazioni metabolico-funzionali grazie all’impiego di traccianti marcati con isotopi radioattivi naturali quali il carbonio-11 ([11C]), l’ossigeno- 15 ([15O]), l’azoto-13 ([13N]) e il fluoro-18 ([18F]). I traccianti sintetizzati rappresentano infatti i substrati naturali dei principali processi metabolici della cellula. Lo studio PET, complementare a indagini morfologiche quali l’ecografia, la radiografia tradizionale, la tomografia computerizzata (TC) e la risonanza magnetica (RM), consente la caratterizzazione metabolica di lesioni identificate — o non — con le metodiche radiologiche. La presenza e l’estensione della patologia neoplastica possono essere indagate nell’ambito di tutti i distretti corporei, in maniera non invasiva.
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Bibliografia
Kapoor V, McCook BM, Torok FS (2004) An introduction to PET-CT imaging. Radiographics 24:523–543
Pauwels EK, Sturm EJ, Bombardieri E et al (2000) Positron-emission tomography with [18F]fluorodeoxyglucose. Part I. Biochemical uptake mechanism and its implication for clinical studies. J Cancer Res Clin Oncol 126:549–559
Yeh SD, Imbriaco M, Larson SM et al (1996) Detection of bony metastases of androgen-independent prostate cancer by PET-FDG. Nucl Med Biol 23:693–697
Shreve PD, Grossman HB, Gross MD, Wahl RL (1996) Metastatic prostate cancer: initial findings of PET with 2-deoxy-2-[F-18]fluoro-D-glucose. Radiology 199:751–756
Hara T, Kosaka N, Kishi H (1998) PET imaging of prostate cancer using carbon-11-choline. J Nucl Med 39:990–995
Hara T, Kosaka N, Shinoura N, Kondo T (1997) PET imaging of brain tumor with [methyl-11C]choline. J Nucl Med 38:842–847
Khan N, Oriuchi N, Zhang H et al (2003) A comparative study of 11C-choline PET and [18F]fluorodeoxyglucose PET in the evaluation of lung cancer. Nucl Med Commun 24:359–366
Picchio M, Treiber U, Beer AJ et al (2006) Value of 11Ccholine PET and contrast-enhanced CT for staging of bladder cancer: correlation with histopathologic findings. J Nucl Med 47:938–944
Kotzerke J, Prang J, Neumaier B et al (2000) Experience with carbon-11 choline positron emission tomography in prostate carcinoma. Eur J Nucl Med 27:1415–1419
Yoshida S, Nakagomi K, Goto S et al (2005) 11C-choline positron emission tomography in prostate cancer: primary staging and recurrent site staging. Urol Int 74:214–220
Reske SN, Blumstein NM, Neumaier B et al (2006) Imaging prostate cancer with 11C-choline PET/CT. J Nucl Med 47: 1249–1254
Scher B, Seitz M, Albinger W et al (2007) Value of 11Ccholine PET and PET/CT in patients with suspected prostate cancer. Eur J Nucl Med Mol Imaging 34:45–53
Sutinen E, Nurmi M, Roivainen A et al (2004) Kinetics of [(11)C]choline uptake in prostate cancer: a PET study. Eur J Nucl Med Mol Imaging 31:317–324
Farsad M, Schiavina R, Castellucci P et al (2005) Detection and localization of prostate cancer: correlation of (11)Ccholine PET/CT with histopathologic step-section analysis. J Nucl Med 46:1642–1649
Giovacchini G, Picchio M, Coradeschi E et al (2008) [(11)C]choline uptake with PET/CT for the initial diagnosis of prostate cancer: relation to PSA levels, tumour stage and anti-androgenic therapy. Eur J Nucl Med Mol Imaging 35:1065–1073
Martorana G, Schiavina R, Corti B et al (2006) 11C-choline positron emission tomography/computerized tomography for tumor localization of primary prostate cancer in comparison with 12-core biopsy. J Urol 176:954–960
Rinnab L, Blumstein NM, Mottaghy FM et al (2007) 11Ccholine positron-emission tomography/computed tomography and transrectal ultrasonography for staging localized prostate cancer. BJU Int 99:1421–1426
de Jong IJ, Pruim J, Elsinga PH et al (2003) Preoperative staging of pelvic lymph nodes in prostate cancer by 11Ccholine PET. J Nucl Med 44:331–335
Schiavina R, Scattoni V, Castellucci P et al (2008) (11)Ccholine positron emission tomography/computerized tomography for preoperative lymph-node staging in intermediate-risk and high-risk prostate cancer: comparison with clinical staging nomograms. Eur Urol 54:392–401
de Jong IJ, Pruim J, Elsinga PH et al (2003) 11C-choline positron emission tomography for the evaluation after treatment of localized prostate cancer. Eur Urol 44:32–38
Picchio M, Messa C, Landoni C et al (2003) Value of [11C] choline-positron emission tomography for re-staging prostate cancer: a comparison with [18F]fluorodeoxyglucosepositron emission tomography. J Urol 169:1337–1340
Rinnab L, Mottaghy FM, Blumstein NM et al (2007) Evaluation of [11C]-choline positron-emission/computed tomography in patients with increasing prostate-specific antigen levels after primary treatment for prostate cancer. BJU Int 100:786–793
Scattoni V, Picchio M, Suardi N et al (2007) Detection of lymph-node metastases with integrated [11C]choline PET/CT in patients with PSA failure after radical retropubic prostatectomy: results confirmed by open pelvic-retroperitoneal lymphadenectomy. Eur Urol 52:423–429
Reske SN, Blumstein NM, Glatting G (2008): [(11)C]choline PET/CT imaging in occult local relapse of prostate cancer after radical prostatectomy. Eur J Nucl Med Mol Imaging 35:9–17
Krause BJ, Souvatzoglou M, Tuncel M et al (2008) The detection rate of [(11)C]Choline-PET/CT depends on the serum PSA-value in patients with biochemical recurrence of prostate cancer. Eur J Nucl Med Mol Imaging 35:18–23
Tuncel M, Souvatzoglou M, Herrmann K et al (2008) [(11)C]Choline positron emission tomography/computed tomography for staging and restaging of patients with advanced prostate cancer. Nucl Med Biol 35:689–695
Heidenreich A, Aus G, Bolla M et al (2008) EAU guidelines on prostate cancer. Eur Urol 53:68–80
Fazio F, Picchio M, Messa C (2004): Is 11C-choline the most appropriate tracer for prostate cancer? For. Eur J Nucl Med Mol Imaging 31:753–756
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Picchio, M., Crivellaro, C., Gianolli, L., Messa, C. (2010). Carcinoma prostatico e ruolo della PET-TC. In: Passariello, R., Panebianco, V., Di Silverio, F., Sciarra, A. (eds) Imaging RM della prostata. Springer, Milano. https://doi.org/10.1007/978-88-470-1516-6_20
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DOI: https://doi.org/10.1007/978-88-470-1516-6_20
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