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Inflammation and Perinatal Brain Injury

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Neonatology

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Abstract

Inflammation is a systemic and local immune reaction to injury secondary to microbial invasion or other damaging events like trauma and hypoxia-ischemia (Fig. 128.1). This response aids in identifying extrinsic pathogens and kills microbes (and affected cells) if the injury is caused by infection [1]. Irrespective of the primary triggering event, inflammation often causes brain damage during its acute stage (collateral damage) followed by a secondary phase that in most cases promotes tissue repair and regeneration [2].

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Authors and Affiliations

  1. Institute of Reproductive and Developmental Biology, Imperial College, London, UK

    Henrik Hagberg

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  1. Henrik Hagberg
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  2. Carina Mallard
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  3. Karin Sävman
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Editors and Affiliations

  1. Department of Pediatrics, Obstetrics and Reproductive Medicine, Division of Neonatology, University of Siena General Hospital S. Maria alle Scotte Azienda Ospedaliera Universitaria Senese, Siena, Italy

    Giuseppe Buonocore (Professor of Pediatrics and Neonatology, Head of School of Pediatrics) (Professor of Pediatrics and Neonatology, Head of School of Pediatrics)

  2. University of Siena, Siena, Italy

    Rodolfo Bracci (Formerly Professor of Pediatrics and Head of Department of Pediatrics, Obstetrics and Reproductive Medicine) (Formerly Professor of Pediatrics and Head of Department of Pediatrics, Obstetrics and Reproductive Medicine)

  3. University of Liverpool, UK

    Michael Weindling (Professor of Perinatal Medicine, Director of Postgraduate Research, Head of School of Paediatrics Mersey Deanery) (Professor of Perinatal Medicine, Director of Postgraduate Research, Head of School of Paediatrics Mersey Deanery)

  4. Department of Women’s and Children’s Health, Institute of Translational Medicine, Liverpool, UK

    Michael Weindling (Professor of Perinatal Medicine, Director of Postgraduate Research, Head of School of Paediatrics Mersey Deanery) (Professor of Perinatal Medicine, Director of Postgraduate Research, Head of School of Paediatrics Mersey Deanery)

  5. Liverpool Women’s Hospital, Liverpool, UK

    Michael Weindling (Professor of Perinatal Medicine, Director of Postgraduate Research, Head of School of Paediatrics Mersey Deanery) (Professor of Perinatal Medicine, Director of Postgraduate Research, Head of School of Paediatrics Mersey Deanery)

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Hagberg, H., Mallard, C., Sävman, K. (2012). Inflammation and Perinatal Brain Injury. In: Buonocore, G., Bracci, R., Weindling, M. (eds) Neonatology. Springer, Milano. https://doi.org/10.1007/978-88-470-1405-3_128

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