Skip to main content
  • 1136 Accesses

Abstract

Metabolic bone disease encompasses a number of disorders that typically show involvement of the entire skeleton. They are mostly associated with increased bone turnover and increased uptake of radiolabeled diphosphonate. The increased uptake produces heightened contrast on bone scan between bone and soft tissues, deceptively giving the appearance of excellent image quality. In more severe cases, there may be characteristic patterns of abnormality, including one or more of the following metabolic features [1]:

  1. 1.

    Increased tracer uptake in the long bones

  2. 2.

    Increased tracer uptake in the axial skeleton

  3. 3.

    Increased uptake in the periarticular areas

  4. 4.

    Faint or almost absent kidney images

  5. 5.

    Prominent calvaria and mandibule

  6. 6.

    Beading of the costochondral junctions

  7. 7.

    “Tie” sternum

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Fogelman I, Citrin DL, Turner JG et al (1979) Semiquantitative interpretation of the bone scan in metabolic bone disease. Eur J Nucl Med 4:287–289

    Article  CAS  PubMed  Google Scholar 

  2. Weighmann T, Rosenthall L, Kaye M (1977) Technetium 99m pyrophosphate bone scan in hyperparathyroidism. J Nucl Med 18:231

    Google Scholar 

  3. Fogelman I, McKillop JH, Bessant RG et al (1978) The role of bone scanning in osteomalacia. J Nucl Med 19:245–248

    CAS  PubMed  Google Scholar 

  4. Sy WM (1981) Osteoporosis. In: Sy WM (ed) Gamma images in benign and metabolic bone disease. CRC, Boca Raiton, FL, pp 223–239

    Google Scholar 

  5. Fogelman I, Carr D (1988) A comparison between bone scanning and radiology in the evaluation of patients with metabolic bone disease. Clin Radiol 31:321–326

    Article  Google Scholar 

  6. Ryan PJ, Fogelman I (1994) Osteoporotic vertebral fractures. Comparison with radiography and bone scintigraphy. Radiology 190:669–672

    CAS  PubMed  Google Scholar 

  7. Ryan PJ, Evans PA, Gibson T, Fogelman I (1992) Osteoporosis and chronic low back pain. A study with single photon emission computed bone scintigraphy. J Bone Miner Res 7:1455–1459

    Article  CAS  PubMed  Google Scholar 

  8. Serafini AN (1976) Paget’s disease of bone. Semin Nucl Med 6:47–58

    Article  CAS  PubMed  Google Scholar 

  9. Ryan PJ, Gibson T, Fogelman I (1992) Bone scintigraphy following pamidronate therapy for Paget’s Disease of Bone. J Nucl Med 33:1589–1593

    CAS  PubMed  Google Scholar 

  10. Cook GJR, Maisey M, Fogelman I (1999) Fluorine 18 FDG PET in Paget’s disease of Bone. J Nucl Med 43:259–268

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer-Verlag Italia

About this chapter

Cite this chapter

Ryan, P.J. (2009). Metabolic Bone Disease. In: Hodler, J., Zollikofer, C.L., Von Schulthess, G.K. (eds) Musculoskeletal Diseases 2009–2012. Springer, Milano. https://doi.org/10.1007/978-88-470-1378-0_30

Download citation

  • DOI: https://doi.org/10.1007/978-88-470-1378-0_30

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-1377-3

  • Online ISBN: 978-88-470-1378-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics