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Induction of High-Level Chimerism in Composite Tissue Transplants

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Hand Transplantation
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Abstract

Although the prolonged survival of experimental composite tissue allografts (CTAs) is achievable using immunosuppressive drugs, long-term immunosuppression of CTAs is not acceptable in the clinical setting because of serious side-effects. The development of a model for reliable CTA tolerance induction across a major histocompatibility complex (MHC) mismatch and without the need for long-term immunosuppression is highly desirable.

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References

  1. Starzl TE, Demetris AJ, Murase N et al (1992) Cell migration, chimerism, and graft acceptance. Lancet 339:1579–1582

    Article  PubMed  CAS  Google Scholar 

  2. Monaco AP (2003) Chimerism in organ transplantation: conflicting experiments and clinical observations. Transplantation 75:13–16

    Article  Google Scholar 

  3. Muramatsu K, Kurokawa Y, Ihara K et al (2005) Donor cell engraftment in recipient lymphoid tissues after rat limb allograft. J Surg Res 124:38–44

    Article  PubMed  Google Scholar 

  4. Muramatsu K, Bishop AT, Sunagawa T, Valenzuela RG (2003) Fate of donor cells in vascularized bone grafts: identification of systemic chimerism by the polymerase chain reaction. Plast Reconstr Surg 111:763–772

    Article  PubMed  Google Scholar 

  5. Muramatsu K, Valenzuela RG, Bishop AT (2003) Detection of chimerism following vascularized bone allotransplantation by polymerase chain reaction using a Y-chromosome specific primer. J Orthop Res 21:1056–1062

    Article  PubMed  CAS  Google Scholar 

  6. Foster RD, Ascher NL, McCalmont TH et al (2001) Mixed allogeneic chimerism as a reliable model for composite tissue allograft tolerance induction across major and minor histocompatibility barriers. Transplantation 72:791–797

    Article  PubMed  CAS  Google Scholar 

  7. Foster RD, Fan L, Neipp M et al (1998) Donor-specific tolerance induction in composite tissue allografts. Am J Surg 176:418–421

    Article  PubMed  CAS  Google Scholar 

  8. Takahashi M, Hakamata Y, Takeuchi K, Kobayashi E (2003) Effects of different fixatives on beta-galactosidase activity. J Histochem Cytochem 51:553–554

    PubMed  CAS  Google Scholar 

  9. Takahashi M, Hakamata Y, Kobayashi E et al (2003) Establishment of lacZ-transgenic rats: a tool for regenerative research in myocardium. Biochem Biophys Res Commun 305:904–908

    Article  PubMed  CAS  Google Scholar 

  10. Muramatsu K, Doi K, Kawai S et al (1999) Limb allotransplantation in rats: combined immunosuppression by FK-506 and 15-deoxyspergualin. J Hand Surg 24:586–593

    Article  CAS  Google Scholar 

  11. Colson YL, Zadach, K, Nalesnik M, Ildstad ST (1995) Mixed allogeneic chimerism in the rat. Donor-specific transplantation tolerance without chronic rejection for primarily vascularized cardiac allografts. Transplantation 60:971–980

    PubMed  CAS  Google Scholar 

  12. Hewitt CW, Ramsamooj R, Black KS et al (1990) Development of stable mixed T cell chimerism and transplantation tolerance without immune modulation in recipients of vascularized bone marrow allografts. Transplantation 50:766–772

    Article  PubMed  CAS  Google Scholar 

  13. Esumi T, Inaba M, Ikehara S et al (2003) Successful allogeneic leg transplantation in rats in conjunction with intra-bone marrow injection of donor bone marrow cells. Transplantation 76:1543–1548

    Article  PubMed  CAS  Google Scholar 

  14. Ajiki T, Takahashi M, Kobayashi E et al (2003) Generation of donor hematolymphoid cells after rat-limb composite grafting. Transplantation 75:631–636

    Article  PubMed  CAS  Google Scholar 

  15. Mathes DW, Randolph MA, Lee WP et al (2002) Recipient bone marrow engraftment in donor tissue after long-term tolerance to a composite tissue allograft. Transplantation 73:1880–1885

    Article  PubMed  Google Scholar 

  16. Granger DK, Breidenbach WC, Kaufman CL et al (2002) Lack of donor hyporesponsiveness and donor chimerism after clinical transplantation of the hand. Transplantation 74:1624–1630

    Article  PubMed  Google Scholar 

  17. Tomita Y, Nomoto K (1990) Induction of tolerance to non-H-2 alloantigens is not restricted by the MHC molecules expressed on the donor cells in cyclophosphamide-induced tolerance. Immunobiology 181:430–437

    PubMed  CAS  Google Scholar 

  18. Zhang QW, Mayumi H, Yasui H et al (1997) Fractionated dosing of cyclophosphamide for establishing long-lasting skin allograft survival, stable mixed chimerism, and intrathymic clonal deletion in mice primed with allogeneic spleen cells. Transplantation 63:1667–1673

    Article  PubMed  CAS  Google Scholar 

  19. Mayumi H, Umesue M, Nomoto K (1996) Cyclophosphamide-induced immunological tolerance: an overview. Immunobiology 195:129–139

    PubMed  CAS  Google Scholar 

  20. Iwai T, Tomita Y, Yasui H et al (2005) Requirement of a higher degree of chimerism for skin allograft tolerance in cyclophosphamide-induced tolerance. Transpl Int 17:795–803

    Article  PubMed  CAS  Google Scholar 

  21. Okayama J, Ko S, Nakajima Y et al (2004) Bone marrow chimerism and tolerance induced by single-dose cyclophosphamide. J Surg Res 120:102–110

    Article  PubMed  CAS  Google Scholar 

  22. Okabe T, Nomura H, Sato N, Ohsawa N et al (1982) Large-scale preparation and characterization of human colony-stimulating factor. J Cell Physiol 110:43–49

    Article  PubMed  CAS  Google Scholar 

  23. Ramsamooj R, Llull R, Black KS, Hewitt CW (1999) Composite tissue allografts in rats: IV. Graft-versus-host disease in recipients of vascularized bone marrow transplants. Plast Reconstr Surg 104:1365–1371

    Article  PubMed  CAS  Google Scholar 

  24. Gorantla VS, Prabhune KA, Barker JH et al (2003) Composite tissue allotransplantation in chimeric hosts: part I. Prevention of graft-versus-host disease. Transplantation 75:922–932

    Article  PubMed  Google Scholar 

  25. Prabhune KA, Gorantla VS, Maldonado C et al (2003) Composite tissue allotransplantation in chimeric hosts. Part II. A clinically relevant protocol to induce tolerance in a rat model. Transplantation 76:1548–1555

    Article  PubMed  Google Scholar 

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© 2007 Springer-Verlag Italia

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Muramatsu, K., Doi, K., Tanaka, H., Taguchi, T. (2007). Induction of High-Level Chimerism in Composite Tissue Transplants. In: Lanzetta, M., Dubernard, JM., Petruzzo, P. (eds) Hand Transplantation. Springer, Milano. https://doi.org/10.1007/978-88-470-0374-3_5

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  • DOI: https://doi.org/10.1007/978-88-470-0374-3_5

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0373-6

  • Online ISBN: 978-88-470-0374-3

  • eBook Packages: MedicineMedicine (R0)

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