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Management of Infertility in Klinefelter Syndrome

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Male Infertility

Abstract

Klinefelter syndrome (KS) is a relatively common disorder with significant morbidity. Symptomatic adolescents with hypogonadal KS can be treated with testosterone supplementation therapy for androgen deficiency and concurrent human chorionic gonadotropin (hCG) to preserve fertility. Invasive biopsies and cryopreservation are not recommended in adolescents because they have significant negative effects and provide no advantage compared to delaying such procedures until adulthood when fertility is desired. For adults who have KS and desire fertility, the recommendation is medical therapy to optimize intratesticular testosterone, if the patient has a low serum testosterone level, followed by microdissection testicular sperm extraction (TESE) and pregnancy by intracytoplasmic sperm injection (ICSI). The management of fertility in adults with KS is well established with good pregnancy outcomes.

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Author information

Authors and Affiliations

  1. Baylor College of Medicine, 1150 Northwest 14th Street 309, Miami, FL, 33136, USA

    Ranjith Ramasamy MD

  2. Department of Urology, University of Miami, Miami, FL, USA

    Affan Zafar BS

Authors
  1. Ranjith Ramasamy MD
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  2. Affan Zafar BS
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Correspondence to Ranjith Ramasamy MD .

Editor information

Editors and Affiliations

  1. Metro Male Clinic, Gunasekaran Hospital Pvt Ltd, Chennai, India

    Karthik Gunasekaran

  2. Department of Andrology and Reproductive, Chettinad Hospital and Research Institut, Chennai, India

    N Pandiyan

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© 2017 Springer India

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Ramasamy, R., Zafar, A. (2017). Management of Infertility in Klinefelter Syndrome. In: Gunasekaran, K., Pandiyan, N. (eds) Male Infertility. Springer, New Delhi. https://doi.org/10.1007/978-81-322-3604-7_8

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  • DOI: https://doi.org/10.1007/978-81-322-3604-7_8

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  • Publisher Name: Springer, New Delhi

  • Print ISBN: 978-81-322-3602-3

  • Online ISBN: 978-81-322-3604-7

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