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Structureomics in Systems-Based Drug Discovery

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Systems Biology Application in Synthetic Biology

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Abstract

Selection of the appropriate drug target is crucial and furthermore its association with small molecule binding partners is the subject of extensive studies. Drug discovery has evolved from the traditional serendipity to system based approaches of using the three dimensional structures of biological molecules. This chapter provides a brief description about the contribution of large number of proteins structures in drug discovery. This further elucidates the target selection and its role in reducing the time and efforts required for drug development.

Author Contributions

Conceived and designed the chapter: AKV Performed the analysis: LYR, PT, LD, Wrote the chapter: LYR, AKV.

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Abbreviations

SBDD:

Structure-based drug designing

ADME:

Absorption distribution, metabolism, and excretion

SEM:

Scanning electron microscopy

TEM:

Transmission electron microscopy

XRD:

X-ray diffractometer

PSI:

Protein structure initiative

SGC:

Structural Genomics Consortium

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Authors and Affiliations

  1. Varma Lab, Advanced Centre for Treatment, Research and Education in Cancer, Kharghar, Navi Mumbai, Maharashtra, 410 210, India

    Lumbini R. Yadav, Pankaj Thapa, Lipi Das & Ashok K. Varma

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  1. Lumbini R. Yadav
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  2. Pankaj Thapa
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  3. Lipi Das
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  4. Ashok K. Varma
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Correspondence to Ashok K. Varma .

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  1. Computational and Systems Biology Lab, National Centre for Cell Science, Pune, India

    Shailza Singh

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Yadav, L.R., Thapa, P., Das, L., Varma, A.K. (2016). Structureomics in Systems-Based Drug Discovery. In: Singh, S. (eds) Systems Biology Application in Synthetic Biology. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2809-7_4

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