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Prolactin and Somatostatin Responses to Antidepressant Therapy

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Melatonin, Neuroprotective Agents and Antidepressant Therapy

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Abstract

Neuropeptides have been implicated in the physiology and pathophysiology of stress responses and therefore may play an important role in the pathogenesis of affective disorders such as major depressive disorder (MDD). The data presented in this chapter demonstrate the role of prolactin (PRL) and somatostatin (STT) in the pathology and pharmacotherapy of MDD, focusing particularly on the response to antidepressant treatment, and compare the available data with the results obtained in our laboratory using in vitro model (HEK293 cells line) and the well-validated chronic mild stress (CMS) animal model of MDD.

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  1. Department of Pharmacology, Institute of Pharmacology Polish Academy of Sciences, Smętna Street 12, Kraków, 31-343, Poland

    Agata Faron-Górecka PhD & Kinga Szafran-Pilch

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  1. Agata Faron-Górecka PhD
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Correspondence to Agata Faron-Górecka PhD .

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  1. Vice-Rectorate for Research and Sci, Camilo José Cela University Vice-Rectorate for Research and Sci, Madrid, Spain

    Francisco López-Muñoz

  2. International Medical Sciences Research Study Center, Sri Sathya Sai Medical Educational & Research Foundation, Coimbatore, India

    Venkataramanujam Srinivasan

  3. Department of Neurosciences and Ima, University of Chieti Department of Neurosciences and Ima, Italy, Italy

    Domenico de Berardis

  4. Department of Biomedical Sciences (Pharmacology Area), University of Alcalá, Madrid, Spain

    Cecilio Álamo

  5. Department of Neuropsychiatry, Kyushu University, Fukuoka, Japan

    Takahiro A. Kato

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Faron-Górecka, A., Szafran-Pilch, K. (2016). Prolactin and Somatostatin Responses to Antidepressant Therapy. In: López-Muñoz, F., Srinivasan, V., de Berardis, D., Álamo, C., Kato, T. (eds) Melatonin, Neuroprotective Agents and Antidepressant Therapy. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2803-5_39

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