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The Sea as a Source of New Drugs

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Molecular Imaging for Integrated Medical Therapy and Drug Development

Abstract

The role of natural products in drug discovery has suffered ups and downs during the past few years. Recently, and as the number of classical drugs has not been increasing greatly, it seems that pharmaceutical companies are looking again towards nature as an inspiration for new drugs. Especially interesting has been the fact that during the past few years the first drugs based on natural marine products have been introduced in the markel. showing the enormous potential of the sea as a source of drugs. One of the main problems associated with the use of natural products as therapeutics is their poor pharmacokinetic properties. A strategy for improving these properties is through their chemical modification, which is exemplified herein by work on such structural edition of two natural products (thiocoraline and lamellarin) currently being carried out at our laboratories.

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Author information

Authors and Affiliations

  1. Institute for Research in Biomedicine, Barcelona Science Park, University of Barcelona, Baldiri Reixac 10, E-08028, Barcelona, Spain

    Fernando Albericio, Mercedes Álvarez, Daniel Pla & Judit Tulla-Puche

  2. CIBER-BBN Networking Centre on Bioengineering, Biomaterials and Nanomedicine, Barcelona Science Park, University of Barcelona, Baldiri Reixac 10, E-08028, Barcelona, Spain

    Fernando Albericio, Mercedes Álvarez, Daniel Pla & Judit Tulla-Puche

  3. Department of Organic Chemistry, University of Barcelona, Martí Franqués 1, E-08028, Barcelona, Spain

    Fernando Albericio

  4. Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, Joan XXII s/n, E-08028, Barcelona, Spain

    Mercedes Álvarez

  5. Pharma Mar S. A., Avda de los Reyes 1, E-28770, Colmenar Viejo, Madrid, Spain

    Carmen Cuevas & Andres Francesch

Authors
  1. Fernando Albericio
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  2. Mercedes Álvarez
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  3. Carmen Cuevas
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  4. Andres Francesch
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  5. Daniel Pla
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  6. Judit Tulla-Puche
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Editor information

Editors and Affiliations

  1. Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita-ku, Sapporo, 060-8638, Japan

    Nagara Tamaki M.D., Ph.D.

  2. Department of Tracer Kinetics and Bioanalysis, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita-ku, Sapporo, 060-8638, Japan

    Yuji Kuge Ph.D.

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Albericio, F., Álvarez, M., Cuevas, C., Francesch, A., Pla, D., Tulla-Puche, J. (2010). The Sea as a Source of New Drugs. In: Tamaki, N., Kuge, Y. (eds) Molecular Imaging for Integrated Medical Therapy and Drug Development. Springer, Tokyo. https://doi.org/10.1007/978-4-431-98074-2_24

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  • DOI: https://doi.org/10.1007/978-4-431-98074-2_24

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-98073-5

  • Online ISBN: 978-4-431-98074-2

  • eBook Packages: MedicineMedicine (R0)

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