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Neuroregulation of Mucosal Vasculature

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Allergy Frontiers: Classification and Pathomechanisms

Part of the book series: Allergy Frontiers ((ALLERGY,volume 2))

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Abstract

The profuse microvasculature, present in the airway mucosa, can play a key role in normal homeostasis as well as in airway inflammation. An intricate network of efferent and afferent autonomic nerves regulate the mucosal airway vessels. The nerve/vessel interplay is complex and not yet completely clarified. In response to inspired air conditions, the sensory nerves can recruit appropriate reflexes, which can induce different vascular processes, such as vasodilatation, vasoconstriction, plasma extravasation and exudation. Additionally, the stimulation of C fibres may result in an axon local reflex with antidromic conduction down afferent nerve collaterals and release of sensory neuropeptides, which in turn may act on the mucosal vasculature to promote vasodilatation and microvascular leakage. The neurogenic inflammation may play an important role in allergic diseases, such as asthma, as well as in COPD, a smoking-related disease. The pharmacological modulation of neurogenic inflammation may represent an important approach to chronic inflammatory airway diseases. This chapter deals with the interactions of vessels and nerves within the airway mucosa under healthy conditions and in inflammatory diseases.

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References

  1. Demello DE (2006) Development origins of the bronchial vasculature: experimental approaches to study the structure and function of bronchial vasculature. In: Lazaar A (ed) Bronchial vascular remodelling in asthma and COPD. Informa, New York, pp 1–23

    Google Scholar 

  2. Wilson J (2000) The bronchial microcirculation in asthma. Clin Exp Allergy 30:51–53

    Article  PubMed  Google Scholar 

  3. Chetta A, Zanini A, Torre O, Olivieri D (2007) Vascular remodelling and angiogenesis in asthma: morphological aspects and pharmacological modulation. Inflamm Allergy Drug Targets 6:41–45

    Article  PubMed  CAS  Google Scholar 

  4. Laitinen LA (1988) Detailed analysis of neural elements in human airways. In: Kaliner MA, Barnes PJ (eds) The airways. Neural control in health and disease. Marcel Dekker, New York, pp 35–56

    Google Scholar 

  5. Widdicombe J (1986) The physiology of the nose. Clin Chest Med 7:159–170

    PubMed  CAS  Google Scholar 

  6. Cauna N (1982) Blood and nerve supply of the nasal lining. In: Proctor DF, Anderson I (eds) The nose: upper airway physiology and the atmospheric environment. Elsevier Biomedical Press BV, Amsterdam, pp 45–69

    Google Scholar 

  7. Corfield DR, Webber SE, Widdicombe JG (1993) Distribution of blood flow in the perfused tracheae of sheep: a search for arteriovenous anastomoses. J Appl Physiol 74:1856–1861

    PubMed  CAS  Google Scholar 

  8. Grevers G, Hermann U (1987) Fenestrated endothelia in vessels of the nasal mucosa: an electron microscopic study in the rabbit. Arch Otolaryngol 244:55–60

    CAS  Google Scholar 

  9. Persson CGA (1988) Plasma exudation and asthma. Lung 166:1–23

    Article  PubMed  CAS  Google Scholar 

  10. Widdicombe J (1993) Why are the airways so vascular? Thorax 48:290–295

    Article  PubMed  CAS  Google Scholar 

  11. Wagner EM (1997) Bronchial circulation. In: Crystal Rg, West JB, Weibel ER, Barnes PJ (eds) The lung: scientific foundations. 2nd ed. Lippincott-Raven, Philadelphia, PA, pp 1093–1105

    Google Scholar 

  12. Deffebach ME, Charan NB, Lakshminarayan S, Butler J (1987) The bronchial circulation. Small, but a vital attribute of the lung. Am Rev Respir Dis 135:463–481

    CAS  Google Scholar 

  13. Widdicombe J (1993) The airway vasculature. Exp Physiol 78:433–452

    PubMed  CAS  Google Scholar 

  14. Kuwano K, Bosken CH, Pare PD, Bai TR, Wiggs BR, Hogg JC (1993) Small airways dimensions in asthma and in chronic obstructive pulmonary disease. Am Rev Respir Dis 148:1220–1225

    PubMed  CAS  Google Scholar 

  15. White MV (1995) Muscarinic receptors in human airways. J Allergy Clin Immun 95:1065–1068

    Article  PubMed  CAS  Google Scholar 

  16. Zaagsma J, Roffel AF, Meurs H (1997) Muscarinic control of airway function. Life Sci 60:1061–1068

    Article  PubMed  CAS  Google Scholar 

  17. Wasicko MJ, Leiter JC, Erlichman JS, Strobel RJ, Bartlett D (1991) Nasal and pharyngeal resistance after topical mucosal vasoconstriction in normal humans. Am Rev Respir Dis 144:1048–1052

    PubMed  CAS  Google Scholar 

  18. Lacroix JS, Anggård A, Hökfelt T, O'Hare MM, Fahrenkrug J, Lundberg JM (1990) Neuropeptide Y: presence in sympathetic and parasympathetic innervation of the nasal mucosa. Cell Tissue Res 259:119–128

    Article  PubMed  CAS  Google Scholar 

  19. Spina D, Rigby PJ, Paterson JW, Goldie RG (1989) Alpha 1-adrenoceptor function and auto-radiographic distribution in human asthmatic lung. Brit J Pharmacol 97:701–708

    CAS  Google Scholar 

  20. Lacroix JS (1989) Adrenergic and non-adrenergic mechanisms in sympathetic vascular control of the nasal mucosa. Acta Physiol Scand Suppl 581:1–63

    PubMed  CAS  Google Scholar 

  21. Druce HM, Bonner RF, Patow C, Choo P, Summers RJ, Kaliner MA (1984) Response of nasal blood flow to neurohormones as measured by laser-Doppler velocimetry. J Appl Physiol 57:1276–1283

    PubMed  CAS  Google Scholar 

  22. Carstairs JR, Nimmo AJ, Barnes PJ (1985) Autoradiographic visualization of beta-adreno-ceptor subtypes in human lung. Am Rev Respir Dis 132:541–547

    PubMed  CAS  Google Scholar 

  23. McLean J, Mathews K, Ciarkowski A, Brayton PR, Solomon RW (1976) The effects of topical saline and isoproterenol on nasal airway resistance. J Allergy Clin Immun 58:563–574

    Article  PubMed  CAS  Google Scholar 

  24. Mullol J, Raphael GD, Lundgren JD, Baraniuk JN, Mérida M, Shelhamer JH, Kaliner MA (1992) Comparison of human nasal mucosal secretion in vivo and in vitro. J Allergy Clin Immun 89:584–592

    Article  PubMed  CAS  Google Scholar 

  25. Barnes PJ, Baraniuk JN, Belvisi MG (1991) Neuropeptides in the respiratory tract. Part II. Am Rev Respir Dis 144:1391–1399

    CAS  Google Scholar 

  26. Lacroix JS, Ulman LG, Potter EK (1994) Sympathetic and parasympathetic interaction in vascular control of the nasal mucosa in anaesthetized cats. J Physiol 480:325–331

    PubMed  CAS  Google Scholar 

  27. Baraniuk JN, Druce HM (1998) Neuroregulation of mucosal vasculature In: Holgate ST, Busse WW (eds) Inflammatory mechanisms in asthma. Marcel Dekker, New York, pp 619–637

    Google Scholar 

  28. Widdicombe JG (1998) Autonomic regulation. i-NANC/e-NANC. Am J Respir Crit Care Med 158: S171–S175

    PubMed  CAS  Google Scholar 

  29. Richardson JB (1981) Noradrenergic inhibitory innervation of the lung. Lung 159:315–322

    Article  PubMed  CAS  Google Scholar 

  30. Belvisi MG, Ward JK, Mitchell JA, Barnes PJ (1995) Nitric oxide as a neurotransmitter in human airways. Arch Int Pharmacodyn Ther 329:97–110

    PubMed  CAS  Google Scholar 

  31. Ricciardolo FL, Sterk PJ, Gaston B, Folkerts G (2004) Nitric oxide in health and disease of the respiratory system. Physiol Rev 84:731–765

    Article  PubMed  CAS  Google Scholar 

  32. Barnes PJ, Baraniuk JN, Belvisi MG (1991) Neuropeptides in the respiratory tract. Part I. Am Rev Respir Dis 144:1187–1198

    CAS  Google Scholar 

  33. Leys K, Morice AH, Madonna O, Sever PS (1986) Autoradiographic localisation of VIP receptors in human lung. FEBS Lett 199:198–202

    Article  PubMed  CAS  Google Scholar 

  34. Joos G, Kips J, Pauwels R, Van der Straeten M (1986) The respiratory effects of neuropep-tides. Eur J Respir Dis Suppl 144:107–136

    PubMed  CAS  Google Scholar 

  35. Rogers DF (2001) Motor control of airway goblet cells and glands. Respir Physiol 125:129–144

    Article  PubMed  CAS  Google Scholar 

  36. Widdicombe JG (1990) The NANC system and airway vasculature. Arch Int Pharmacodyn Ther 303:83–99

    PubMed  CAS  Google Scholar 

  37. Stretton D (1991) Non-adrenergic, non-cholinergic neural control of the airways. Clin Exp Pharmacol Physiol 18:675–684

    Article  PubMed  CAS  Google Scholar 

  38. Barnes PJ (1986) Asthma as an axon reflex. Lancet 1:242–245

    Article  PubMed  CAS  Google Scholar 

  39. Solway J, Leff AR (1991) Sensory neuropeptides and airway function. J Appl Physiol 71:2077–2087

    PubMed  CAS  Google Scholar 

  40. Kirchmair R, Marksteiner J, Troger J, Mahata SK, Mahata M, Donnerer J, Amann R, Fischer-Colbrie R, Winkler H, Saria A (1994) Human and rat primary C-fibre afferents store and release secretoneurin, a novel neuropeptide. Eur J Neurosci 6:861–868

    Article  PubMed  CAS  Google Scholar 

  41. Frossard N, Advenier C (1991) Tachykinin receptors and the airways. Life Sci 49:1941–1953

    Article  PubMed  CAS  Google Scholar 

  42. Canning BJ (2006) Neurokinin3 receptor regulation of the airways. Vascul Pharmacol 45:227–234

    Article  PubMed  CAS  Google Scholar 

  43. Barnes PJ (2001) Neurogenic inflammation in the airways. Respir Physiol 125:145–154

    Article  PubMed  CAS  Google Scholar 

  44. Murai M, Maeda Y, Hagiwara D, Miyake H, Ikari N, Matsuo M, Fujii T (1993) Effects of an NK1 receptor antagonist, FK888, on constriction and plasma extravasation induced in guinea pig airway by neurokinins and capsaicin. Eur J Pharmacol 236:7–13

    Article  PubMed  CAS  Google Scholar 

  45. Frossard N, Barnes J (1991) Effect of tachykinins in small human airways. Neuropeptides 19:157–161

    Article  PubMed  CAS  Google Scholar 

  46. Di Maria GU, Bellofiore S, Geppetti P (1998) Regulation of airway neurogenic inflammation by neutral endopeptidase. Eur Respir J 12:1454–1462

    Article  PubMed  Google Scholar 

  47. Palmer JB, Cuss FM, Mulderry PK, Ghatei MA, Springall DR, Cadieux A, Bloom SR, Polak JM, Barnes PJ (1987) Calcitonin gene-related peptide is localised to human airway nerves and potently constricts human airway smooth muscle. Brit J Pharmacol 91:95–101

    CAS  Google Scholar 

  48. Mak JC, Barnes PJ (1988) Autoradiographic localization of calcitonin gene-related peptide (CGRP) binding sites in human and guinea pig lung. Peptides 9:957–963

    Article  PubMed  CAS  Google Scholar 

  49. Springer J, Geppetti P, Fischer A, Groneberg DA (2003) Calcitonin gene-related peptide as inflammatory mediator. Pulm Pharmacol Ther 16:121–130

    Article  PubMed  CAS  Google Scholar 

  50. Renz H (2001) Neurotrophins in bronchial asthma. Respir Res 2:265–268

    Article  PubMed  CAS  Google Scholar 

  51. Schinder AF, Poo M (2000) The neurotrophin hypothesis for synaptic plasticity. Trends Neurosci 23:639–645

    Article  PubMed  CAS  Google Scholar 

  52. Levi-Montalcini R, Dal Toso R, della Valle F, Skaper SD, Leon A (1995) Update of the NGF saga. J Neurol Sci 130:119–127

    Article  PubMed  CAS  Google Scholar 

  53. Leon A, Buriani A, Dal Toso R, Fabris M, Romanello S, Aloe L, Levi-Montalcini R (1994) Mast cells synthesize, store, and release nerve growth factor. Proc Natl Acad Sci USA 91:3739–3743

    Article  PubMed  CAS  Google Scholar 

  54. Ehrhard PB, Erb P, Graumann U, Otten U (1993) Expression of nerve growth factor and nerve growth factor receptor tyrosine kinase Trk in activated CD4-positive T-cell clones. Proc Natl Acad Sci USA 90:10984–10988

    Article  PubMed  CAS  Google Scholar 

  55. Jackson DM, Norris AA, Eady RP (1989) Nedocromil sodium and sensory nerves in the dog lung. Pulm Pharmacol 2:179–184

    Article  PubMed  CAS  Google Scholar 

  56. Nichol GM, Alton EW, Nix A, Geddes DM, Chung KF, Barnes PJ (1990) Effect of inhaled furosemide on metabisulfite- and methacholine-induced bronchoconstriction and nasal potential difference in asthmatic subjects. Am Rev Respir Dis 142:576–580

    PubMed  CAS  Google Scholar 

  57. Belvisi MG, Stretton CD, Verleden GM, Ledingham SJ, Yacoub MH, Barnes PJ (1992) Inhibition of cholinergic neurotransmission in human airways by opioids. J Appl Physiol 72:1096–10100

    Article  PubMed  CAS  Google Scholar 

  58. Joos GF, De Swert KO, Schelfhout V, Pauwels RA (2003) The role of neural inflammation in asthma and chronic obstructive pulmonary disease. Ann NY Acad Sci 992:218–230

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Clinical Sciences, Section of Respiratory Diseases, University of Parma, Padiglione Rasori, Via G. Rasori, Parma, 10 - 43100, Italy

    Alfredo Chetta & Giovanna Pisi

  2. Department of Paediatrics, Cystic Fibrosis Unit, University of Parma, Via A. Gramsci, Parma, 14 - 43100, Italy

    Dario Olivieri

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  1. Alfredo Chetta
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  2. Giovanna Pisi
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  3. Dario Olivieri
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Editors and Affiliations

  1. Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, Japan

    Ruby Pawankar

  2. Southampton General Hospital, University of Southampton, Tremona Road, Southampton, UK

    Stephen T. Holgate

  3. Childrens's Mercy Hospital and Clinic, UMKC School of Medicine, 2401 Gillham Road, Kansas City, MO, 64108, USA

    Lanny J. Rosenwasser

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Chetta, A., Pisi, G., Olivieri, D. (2009). Neuroregulation of Mucosal Vasculature. In: Pawankar, R., Holgate, S.T., Rosenwasser, L.J. (eds) Allergy Frontiers: Classification and Pathomechanisms. Allergy Frontiers, vol 2. Springer, Tokyo. https://doi.org/10.1007/978-4-431-88315-9_30

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  • DOI: https://doi.org/10.1007/978-4-431-88315-9_30

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-88314-2

  • Online ISBN: 978-4-431-88315-9

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