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Biodegradable characteristics of octacalcium phosphate combined with collagen implanted in two bony sites

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Interface Oral Health Science 2007

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Abstract

Synthetic octacalcium phosphate (OCP) has been shown to be a resorbable bone regenerative material. In this study, OCP combined with collagen (OCP/Col) or collagen was implanted into the critical-sized defects or into the subperiosteal region in rat crania and fixed at 4, 8 and 12 weeks after implantation. The percentage of newly formed bone and the tissue including the implant were determined by a histomorphometric analysis. Activities of tartrate resistant acid phosphatase (TRAP) were stained to examine phagocytotic multinucleated giant cells. The effect of implantation on crystalline phase of OCP in the implant was examined by X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). The present study suggests that the bone formation on OCP/Col and biodegradation of OCP/Col is distinct depending on the implantation sites.

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References

  1. Suzuki O, Nakamura M, Miyasaka Y, et al (1991) Bone formation on synthetic precursors of hydroxyapatite. Tohoku J Exp Med 164:37–50

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  2. Kamakura S, Sasaki K, Honda Y, et al (2006) Octacalcium phosphate combined with collagen orthotopically enhances bone regeneration. J Biomed Mater Res B Apple Biomater. 79:210–217

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Author information

Authors and Affiliations

  1. Division of Advanced Prosthetic Dentistry, Tohoku University Graduate School of Dentistry, Sendai, 980-8575, Japan

    Yuko Suzuki, Kouki Hatori & Keiichi Sasaki

  2. Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry, Sendai, 980-8575, Japan

    Yoshitomo Honda, Takahisa Anada & Osamu Suzuki

  3. Department of Translational Research, Center for Translational and Advanced Animal Research, Tohoku University School of Medicine, Sendai, 980-8574, Japan

    Shinji Kamakura

  4. Nippon Meat Packers, Inc., Tsukuba, 300-2646, Japan

    Kazuo Sasaki

Authors
  1. Yuko Suzuki
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  2. Shinji Kamakura
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  3. Kouki Hatori
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  4. Kazuo Sasaki
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  5. Yoshitomo Honda
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  6. Takahisa Anada
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  7. Keiichi Sasaki
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  8. Osamu Suzuki
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Editor information

Editors and Affiliations

  1. School of Dentistry, Tohoku University Graduate, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan

    Makoto Watanabe DDS, Ph.D (Director) (Director)

  2. Division of Dental Biomaterials, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan

    Osamu Okuno Ph.D

  3. Division of Advanced Prosthetic Dentistry, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan

    Keiichi Sasaki DDS, Ph.D

  4. Division of Oral Ecology and Biochemistry, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan

    Nobuhiro Takahashi DDS, Ph.D

  5. Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan

    Osamu Suzuki Ph.D

  6. Department of Microbiology and Immunology, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan

    Haruhiko Takada DDS, Ph.D

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© 2007 Springer

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Suzuki, Y. et al. (2007). Biodegradable characteristics of octacalcium phosphate combined with collagen implanted in two bony sites. In: Watanabe, M., Okuno, O., Sasaki, K., Takahashi, N., Suzuki, O., Takada, H. (eds) Interface Oral Health Science 2007. Springer, Tokyo. https://doi.org/10.1007/978-4-431-76690-2_81

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  • DOI: https://doi.org/10.1007/978-4-431-76690-2_81

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-76689-6

  • Online ISBN: 978-4-431-76690-2

  • eBook Packages: MedicineMedicine (R0)

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