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Glucokinase in Glucose Homeostasis, Diabetes Mellitus, Hypoglycemia, and as Drug Receptor

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Pancreatic Beta Cell in Health and Disease

Abstract

The pivotal role of the glucose phosphorylating enzyme glucokinase in glucose homeostasis is discussed, including its established functions as glucose sensor in pancreatic beta cells and as control step in hepatic carbohydrate metabolism. A brief review of “Glucokinase Disease,” a group of hyper- and hypoglycemic clinical phenotypes caused by mutations of the glucokinase gene and inherited as an autosomal dominant trait, and a concise assessment of a newly discovered class of promising antidiabetic drugs that activate glucokinase allosterically, round out this perspective chapter.

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Authors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Pennsylvania, School of Medicine, 501 Stemmler Hall, 36th & Hamilton Walk, Philadelphia, PA, 19104, USA

    Franz M. Matschinsky

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  1. Franz M. Matschinsky
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Editors and Affiliations

  1. Division of Cellular and Molecular Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan

    Susumu Seino M.D., D.M. Sci. (Professor) (Professor)

  2. Medicine and Human Genetics, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL, 60637, USA

    Graeme I. Bell Ph.D. (Louis Block Distinguished Service Professor) (Louis Block Distinguished Service Professor)

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Matschinsky, F.M. (2008). Glucokinase in Glucose Homeostasis, Diabetes Mellitus, Hypoglycemia, and as Drug Receptor. In: Seino, S., Bell, G.I. (eds) Pancreatic Beta Cell in Health and Disease. Springer, Tokyo. https://doi.org/10.1007/978-4-431-75452-7_21

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