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Pancreatic Beta Cell in Health and Disease

  • Book
  • © 2008

Overview

Editors:
  1. Susumu Seino

    1. Division of Cellular and Molecular Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan

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    You can also search for this editor in PubMed   Google Scholar

  2. Graeme I. Bell

    1. Medicine and Human Genetics, The University of Chicago, Chicago, USA

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (21 chapters)

  1. Front Matter

    Pages I-XV
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  2. Pancreatic Beta Cell and Insulin Biosynthesis

    1. Front Matter

      Pages 1-1
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    2. Architecture of Pancreatic Islets

      • Marcela Brissova, Alvin C. Powers
      Pages 3-11

    3. Transcriptional Regulation of Insulin Gene Expression

      • Isabella Artner, Roland Stein
      Pages 13-30

    4. The Biosynthesis of Insulin

      • Donald F. Steiner
      Pages 31-49

  3. Cell Signaling and Insulin Secretion

    1. Front Matter

      Pages 51-51
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    2. Metabolic Regulation of Insulin Secretion

      • Barbara E. Corkey
      Pages 53-74

    3. Mechanisms of Beta-Cell Death in Diabetes

      • Marc Y. Donath, Jan A. Ehses
      Pages 75-89

    4. Ion Channels and Insulin Secretion

      • David A. Jacobson, Louis H. Philipson
      Pages 91-110

    5. Gap Junctions and Insulin Secretion

      • Philippe Klee, Sabine Bavamian, Anne Charollais, Dorothée Caille, José Cancela, Manon Peyrou et al.
      Pages 111-132

    6. Protein Kinase A-Independent Mechanism of cAMP in Insulin Secretion

      • Susumu Seino, Takashi Miki, Tadao Shibasaki
      Pages 133-146

    7. Regulation of Insulin Granule Exocytosis

      • Erik Renström, Patrik Rorsman
      Pages 147-176

    8. Mechanism of Insulin Exocytosis Analyzed by Imaging Techniques

      • Shinya Nagamatsu, Mica Ohara-Imaizumi
      Pages 177-193

    9. Two-Photon Excitation Imaging of Insulin Exocytosis

      • Noriko Takahashi, Haruo Kasai
      Pages 195-211

  4. Pancreatic Development and Beta-Cell Formation

    1. Front Matter

      Pages 213-213
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    2. Regulation of Beta-Cell Growth and Death

      • Christopher J. Rhodes
      Pages 215-243

    3. Beta-Cell Replication

      • Seth J. Salpeter, Yuval Dor
      Pages 245-263

    4. Stem Cells as a Cure for Diabetes

      • Timo Otonkoski, Meenal Banerjee, Karolina Lundin
      Pages 265-284

    5. Use of Extra-Pancreatic Tissues for Cell Replacement Therapy for Diabetes

      • Irit Meivar-Levy, Sarah Ferber
      Pages 285-312

  5. Incretins and Beta-Cell Function

    1. Front Matter

      Pages 313-313
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Keywords

About this book

The beta cells of the pancreatic islets of Langerhans are the only cells in the body that produce and secrete insulin, a key metabolic hormone, which plays a central role in the maintenance of glucose homeostasis regulating glucose uptake in muscle and adipose tissue as well as carbohydrate, fat, and protein metabolism in these tissues and the liver. Failure of normal beta-cell function can lead to hyperglycemia (diabetes mellitus) or hypoglycemia. While hy- glycemia is a rare and life-threatening condition in which the beta cell secretes too much insulin, diabetes mellitus is a common disorder that is fast bec- ing an epidemic. It is a major threat to human health in the 21st century. The number of diabetic patients worldwide is rapidly increasing and is predicted to reach 380 million by 2025, according to the International Diabetes Fede- tion (IDF). Diabetes mellitus is a heterogeneous disorder with some forms such as maturity-onset diabetes of the young and permanent neonatal diabetes being primary genetic disorders of the beta cell. Monogenic forms of diabetes are an uncommon cause of diabetes representing about 1% of cases. The common forms of diabetes mellitus, designated type 1 and type 2, are multifactorial in origin with both genetic and environmental factors contributing to their development. Type 1 diabetes is caused by autoimmune destruction of beta cells leading to an absolute de? ciency of insulin and fatal hyperglycemia and ketoacidosis if not treated.

Editors and Affiliations

  • Division of Cellular and Molecular Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan

    Susumu Seino

  • Medicine and Human Genetics, The University of Chicago, Chicago, USA

    Graeme I. Bell

Bibliographic Information

  • Book Title: Pancreatic Beta Cell in Health and Disease

  • Editors: Susumu Seino, Graeme I. Bell

  • DOI: https://doi.org/10.1007/978-4-431-75452-7

  • Publisher: Springer Tokyo

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag Tokyo 2008

  • Hardcover ISBN: 978-4-431-75451-0Published: 18 December 2007

  • Softcover ISBN: 978-4-431-99837-2Published: 21 October 2010

  • eBook ISBN: 978-4-431-75452-7Published: 08 April 2008

  • Edition Number: 1

  • Number of Pages: XV, 476

  • Topics: Cell Biology, Diabetes, Molecular Medicine, Internal Medicine

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