Abstract
Hepatitis C virus (HCV) is a positive-stranded, enveloped RNA virus which is classified within the hepacivirus genus of the family Flaviviridae [1]. There is extensive genetic heterogeneity among different HCV strains, with at least six major genotypes and a series of related subtypes recognized thus far [2,3]. Among these, genotype 1 is predominant worldwide and comprised of two major subtypes, genotypes la and lb [2]. Although some clinical studies have found no differences in the clinical expression of liver disease that are related to the genotype of the infecting virus [4], others have suggested that genotype lb infections may be more resistant to interferon therapy [5,6], and may confer greater risk for development of hepatocellular carcinoma than infection with nongenotype lb strains including genotype la viruses [7].
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© 1999 Springer-Verlag Tokyo
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Honda, M., Abell, G., Kaneko, S., Kobayashi, K., Lemon, S.M. (1999). Natural Variation in Translational Activities of the 5′ Nontranslated RNAs of Genotypes 1a and 1b Hepatitis C Virus: Evidence for a Long Range RNA-RNA Interaction Outside of the Internal Ribosomal Entry Segment. In: Okita, K. (eds) HCV and Related Liver Diseases. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68488-6_5
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DOI: https://doi.org/10.1007/978-4-431-68488-6_5
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68490-9
Online ISBN: 978-4-431-68488-6
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