Summary
Neuronal cells subjected to injuries such as trauma and hypoxia are destined to die. Using the motor nerve injury model, we collected and screened several genes associated with nerve injury. This gene screening suggested some molecular mechanisms that might contribute to nerve survival and regeneration after injury. Some of these molecular mechanisms are not seen in the central nervous system. This might be a reason why central nervous system neurons are particularly fragile. To compensate for the lack of gene expression in the injured neuron, use of an adenovirus vector is effective. Adenovirus mediated gene expression prevented injury-induced neuronal death and accelerated neurite elongation in vivo.
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© 2002 Springer-Verlag Tokyo
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Kiyama, H., Kiryu-Seo, S., Namikawa, K. (2002). Gene expression and manipulation in injured neurons. In: Kikuchi, H. (eds) Strategic Medical Science Against Brain Attack. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68430-5_8
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DOI: https://doi.org/10.1007/978-4-431-68430-5_8
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68432-9
Online ISBN: 978-4-431-68430-5
eBook Packages: Springer Book Archive