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Olfactory Reception: From Signal Modulation to Human Genome Mapping

  • Conference paper
Olfaction and Taste XI

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Abstract

Olfactory science has evolved into a comprehensive molecular definition brought about by the realization that broad odorant spectra may still be compatible with receptor genes encoding stereospecific proteins [1–3]. Evidence for the existence of specific molecular reception pathways arose with the discovery of G-protein-coupled second messenger transduction cascades in olfactory ciliary membranes [4–6]. Subsequently, a family of hundreds of G-protein-coupled receptors, first proposed based on the available biochemical data [7–9], became a reality with the cloning of olfactory receptors (ORs) in several vertebrate species [10–12]. It is proposed that when this molecular understanding is combined with human psychophysics and genome analysis, a better picture of human olfactory function will emerge.

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Author information

Authors and Affiliations

  1. Department of Membrane Research and Biophysics, The Weizmann Institute of Science, Rehovot, 76100, Israel

    Nissim Ben-Arie, Miriam Khen, Ruth Gross-Isseroff, Naomi Walker, Shirley Horn-Saban, Uri Gat, Michael Natochin & Doron Lancet

  2. Department of Genome Analysis, Imperial Cancer Research Fund, Lincoln’s Inn Fields, London, WC2A 3PX, UK

    Michael North & Hans Lehrach

Authors
  1. Nissim Ben-Arie
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  2. Michael North
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  3. Miriam Khen
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  4. Ruth Gross-Isseroff
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  5. Naomi Walker
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  6. Shirley Horn-Saban
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  7. Uri Gat
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  8. Michael Natochin
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  9. Hans Lehrach
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  10. Doron Lancet
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Editor information

Editors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Hokkaido University, N-13 W-6, Kita-ku, Sapporo, 060, Japan

    Kenzo Kurihara D.S. (Professor) (Professor)

  2. Animal Behavior and Intelligence, Division of Biological Sciences, Graduate School of Science, Hokkaido University, N-10 W-8, Kita-ku, Sapporo, 060, Japan

    Noriyo Suzuki D.S. (Associate Professor) (Associate Professor)

  3. Department of Physiology, Kumamoto University School of Medicine, 2-2-1 Honjo, Kumamoto, 860, Japan

    Hisashi Ogawa M.D., D.M.S. (Professor) (Professor)

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© 1994 Springer Japan

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Ben-Arie, N. et al. (1994). Olfactory Reception: From Signal Modulation to Human Genome Mapping. In: Kurihara, K., Suzuki, N., Ogawa, H. (eds) Olfaction and Taste XI. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68355-1_54

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  • DOI: https://doi.org/10.1007/978-4-431-68355-1_54

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68357-5

  • Online ISBN: 978-4-431-68355-1

  • eBook Packages: Springer Book Archive

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