Skip to main content
SpringerLink
Log in

Clinical Classification and Incidence of Malignant Hyperthermia in Japan

  • Conference paper
Malignant Hyperthermia

Abstract

Denborough and Lovell [1] first described malignant hyperthermia (MH) as an inherited syndrome in 1960. At present, it is generally accepted that MH is triggered by many anesthetics. Succinylcholine chloride (SCC) and volatile anesthetics have been especially implicated as important triggering drugs [2,3]. With these triggering drugs, induced hypermetabolism produces tachycardia, increased O2 consumption and CO2 production, premature ventricular contraction, hypotension and hypertension, cyanosis, tachypnea, muscle rigidity, and hyperthermia as the signs of MH. Also seen as complications of MH are electrolyte imbalances, myoglobinuria, hyperkalemia, creatine phosphokinase (CPK) elevation, impaired coagulation, renal failure, and severe metabolic and respiratory acidosis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 54.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Denborough MA, Lovell RRH (1960) Anesthetic deaths in a family. Lancet 2: 45

    Article  Google Scholar 

  2. Gronert GA (1980) Malignant hyperthermia. Anesthesiology 53: 395–423

    Article  PubMed  CAS  Google Scholar 

  3. Kaplan RF (1991) Malignant hyperthermia. In: 42th annual reference course lectures the American Society of Anesthiologists (ASA), p 2311

    Google Scholar 

  4. Britt BA, Kalow W (1970) Malignant hyperthermia: statistical review. Can Anesth Soc J 17: 293–315

    Article  CAS  Google Scholar 

  5. Ellis FR, Halsall PJ (1980) Malignant hyperpyrexia. Br J Hosp Med 24: 318–327

    PubMed  CAS  Google Scholar 

  6. Ording H (1985) Incidence of malignant hyperthermia in Denmark. Anesth Analg 64: 700–704

    PubMed  CAS  Google Scholar 

  7. Morio M, Kikuchi H, Yuge O, et al (1987) Incidence of malignant Hyperthermia. In: Proceedings, 7th European congress of anesthesiologists, vol III, pp 82–88

    Google Scholar 

  8. Kikuchi H, Matsui I, Morio M (1987) Diagnosis of malignant hyperthermia in Japan by the skinned fiber test. In: Britt BA (ed) Malignant hyperthermia. Nijhoff, Dordrecht, pp 279–294

    Chapter  Google Scholar 

  9. Nakao M, Mukaida K, Kubota M, et al (1991) Variable incidences of fulminant malignant hyperthermia in Japan. In: Proceedings, 14th Japan MH Sympo., pp 83–85

    Google Scholar 

  10. Strazis KP, Fox AW (1993) Malignant hyperthermia: a review of published cases. Anesth Analg, 77: 297–304

    PubMed  CAS  Google Scholar 

  11. Heilinger D, Donner E, Sauberer A, et al (1994) Malignant hyperthermia in Austria 1984–1993. In: 3rd international symposium on malignant hyperthermia, abstract 23

    Google Scholar 

  12. Kalow W, Britt BA, Terreau ME, et al (1970) Metabolic error of muscle metabolism after recovery from malignant hyperthermia. Lancet 2: 895–898

    Article  PubMed  CAS  Google Scholar 

  13. Ellis FR, Harriman DGF, Keaney NP, et al (1971) Halothane-induced muscle contracture as a cause of hyperpyrexia. Br J Anaesth 43: 721–722

    PubMed  CAS  Google Scholar 

  14. Kalow W, Britt BA, Richter A (1977) The caffeine test of isolated human muscle in relation to malignant hyperthermia. Can Anaesth Soc J 24: 678–694

    Article  PubMed  CAS  Google Scholar 

  15. Kawana Y, lino M, Horiuti K, et al (1992) Acceleration in calcium-induced calcium release in the biopsied muscle fibers from patients with malignant hyperthermia. Biomed Res 13 (4): 287–297

    Google Scholar 

  16. Matsui K, Fujioka Y, Mukaida K, et al (1989) Comparative study on in vitro diagnosis by the skinned fiber test and clinical diagnosis of malignant hyperthermia. Masui (Jpn J Anesthesiol) 38: 195–201

    CAS  Google Scholar 

  17. Endo M, Yagi S, Ishizuka T, et al (1983) Changes in the Ca-induced Ca release mechanism in the sarcoplasmic reticulum of the muscle from a patient with malignant hyperthermia. Biomed Res 4: 83–92

    CAS  Google Scholar 

  18. McCarthy TV, Healy JMS, Heffron JJA, et al (1990) Localization of the malignant hyperthermia susceptibility locus to human chromosome 19q12–13.2. Nature 343: 562–564

    Article  PubMed  CAS  Google Scholar 

  19. Gillard EF, Otsu K, Fujii J, et al (1991) A substitution of cysteine for arginine 614 in the ryanodine receptor is potentially causative of human malignant hyperthermia. Genomics 11: 751–755

    Article  PubMed  CAS  Google Scholar 

  20. Larach MG, Localio AR, Allen GC, et al (1994) A clinical grading scale to predict malignant hyperthermia susceptibility. Anesthesiology 80: 771–779

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Anesthesiology and Critical Care Medicine, Hiroshima University School of Medicine, Hiroshima, 734, Japan

    Osafumi Yuge, Keiko Mukaida, Yasuhiro Maehara, Masakazu Nakao & Masashi Kawamoto

  2. Chugoku Rosai General Hospital, Kure, Hiroshima, 737-01, Japan

    Michio Morio

  3. First Department of Anesthesiology, Toho University School of Medicine, Tokyo, 143, Japan

    Hirosato Kikuchi

Authors
  1. Osafumi Yuge
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michio Morio
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hirosato Kikuchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Keiko Mukaida
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yasuhiro Maehara
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Masakazu Nakao
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Masashi Kawamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Chugoku Rosai General Hospital, Hiroshima University, 737-01, Kure, Hiroshima, Japan

    Michio Morio M.D., Ph.D. (Professor Emeritus, Director General) (Professor Emeritus, Director General)

  2. The First Department of Anesthesiology, Toho University School of Medicine, Ohta-ku, Tokyo, 143, Japan

    Hirosato Kikuchi M.D., Ph.D. (Chairman and Professor) (Chairman and Professor)

  3. Department of Anesthesiology and Critical Care Medicine, Hiroshima University School of Medicine, Hiroshima, 734, Japan

    Osafumi Yuge M.D., Ph.D. (Professor and Chairman) (Professor and Chairman)

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Tokyo

About this paper

Cite this paper

Yuge, O. et al. (1996). Clinical Classification and Incidence of Malignant Hyperthermia in Japan. In: Morio, M., Kikuchi, H., Yuge, O. (eds) Malignant Hyperthermia. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68346-9_7

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-68346-9_7

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68348-3

  • Online ISBN: 978-4-431-68346-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation