Abstract
During the past decade, a considerable research effort has been directed toward substantiation of the hypothesized role of free radicals and lipid peroxidation in the occurrence of ischemic brain damage. Regarding the enhanced generation of active oxygens and the occurrence of lipid peroxidation during or following cerebral ischemia, however, experimental results have not been consistent. Although favorable effects of some free radical scavengers on ischemic brain damage were reported by some authors, the exact mechanism of action of each drug has remained uncertain. Therefore, the theory remains controversial as yet, and it seems justified to question what the real significance of free radical mechanism is in the occurrence of ischemic brain damage.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aritake K, Wakai S, Asano T, Takakura K (1983) Peroxidation of arachidonic acid and brain edema. Brain Nerve 35:965–973
Asano T, Johshita H, Koide T, Takakura K (1984) Amelioration of ischemic cerebral edema by a free radical scavenger, AVS, 1,2-Bis(nicotinamide)-propane: An experimental study using a regional ischemia model in cats. Neurol Res 6:163–168
Asano T, Matsui T, Basugi N, Tamura A, Takakura K, Sano K (1984) The effect of indomethacin on cortical specific gravity during regional ischemia and recirculation. In: Go KG, Baethmann A (eds) Recent progress in the study and therapy of brain edema. Plenum, New York, pp 617–626
Asano T, Gotoh O, Koide T, Takakura K (1985) Ischémic brain edema following occlusion of the middle cerebral artery in the rat: II. Alteration of the eicosanoid synthesis profile of brain micro vessels. Stroke 16:110–113
Asano T, Shigeno T, Hanamura T, Koide T, Matsushita H, Watanabe E, Mima T, Johshita H, Usui M, Takakura K (1985) Alteration of brain capillary function in cerebral ischemia: Role of capillary Na+, K+-ATPase in ischemic edema formation. J Cereb Blood Flow Metabol. 5(Suppl 1): S63–S64
Chan PH, Fishman RA, Caronna J, Schmidley JW, Prioleau G, Lee J (1983) Induction of brain edema following intracerebral injection of arachidonic acid. Ann Neurol 13:625–632
Gaudet RJ, Alam I, Levine L (1980) Accumulation of cyclooxygenase products of arachidonic acid metabolism in gerbil brain during reperfusion after bilateral common carotid artery occlusion. J Neurochem 35:653–658
Gaudet RJ, Levine L (1980) Effect of unilateral common carotid artery occlusion on levels of prostaglandins D2, F2a , and 5-keto-prostaglandin F1a in gerbil brain. Stroke 11:648–652
Goldstein GW, Betz AL (1983) Recent advances in understanding brain capillary function. Ann Neurol 14:389–395
Gotoh O, Koide T, Asano T, Takakura K, Tamura A, Sano K (1984) A model to study ischemic brain edema in rats and the influence of drugs. In: Go KG, Baethmann A (eds) Recent progress in the study and therapy of brain edema. Plenum, New York, pp 499–508
Gotoh O, Asano T, Koide T, Takakura K (1985) Ischémie brain edema following occlusion of the middle cerebral artery in the rat: I. The time courses of brain water, sodium, and potassium contents and blood-brain barrier permeability to 125I-albumin. Stroke 16:101–109
Kiwak KJ, Moskowitz MA, Levine L (1985) Leukotriene production in gerbil brain after ischemic insult, subarachnoid hemorrhage, and concussive injury. J Neurosurg 62:865–869
Koide T, Gotoh O, Asano T, Takakura K (1985) Alterations of the eicosanoid synthetic capacity of rat brain microvessels following ischemia: Relevance to ischemic brain edema. J Neurochem 44:85–93
Koide T, Asano T, Matsushita H, Takakura K (1986) Enhancement of ATPase activity by a lipid peroxide of arachidonic acid in rat brain microvessels. J Neurochem 46:235–242
Lands WEM, Kulmacz RJ, Marshall PJ (1984) Lipid peroxide actions in the regulation of prostaglandin biosynthesis. In: Pryor WA (ed), Free radicals in biology, vol. 6. Academic, Orlando, pp 39–63
Usui M, Asano T, Takakura K (in press) Identification and quantitative analysis of hydroxyeicosatetraenoic acids in the rat brain exposed to regional ischemia. Stroke
Yoshida S, Inoh S, Asano T, Sano K, Kubota M, Shimaziki H, Ueta N (1980) Effect of transient ischemia on free fatty acids and phospholipids in the gerbil brain: Lipid peroxidation as possible cause of postischemic injury. J Neurosurg 53:323–331
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer Japan
About this paper
Cite this paper
Asano, T., Shigeno, T., Johshita, H., Hanamura, T. (1988). The Possible Role of Free Radical Scavengers in the Mitigation of Ischemic Brain Damage. In: Suzuki, J. (eds) Advances in Surgery for Cerebral Stroke. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68314-8_47
Download citation
DOI: https://doi.org/10.1007/978-4-431-68314-8_47
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68316-2
Online ISBN: 978-4-431-68314-8
eBook Packages: Springer Book Archive