Summary
The properties of interstitial fluid in the periventricular white matter in normal pressure hydrocephalus (NPH) were evaluated by measurement of the relaxation times of brain water protons. Patients with NPH were divided into two groups: Shunt responders and shunt non-responders. In the shunt responder group both T1 and T2 values of the periventricular white matter were significantly prolonged compared to those of the controls, and were shortened after shunting. Both T1 and T2 values of the white matter were significantly longer than those of the gray matter, while the reverse relationship was seen in normal controls. However, in the shunt non-responder group, although T1 of the white matter was significantly prolonged, T2 of the same area was not. There was no change in either T1 or T2 of this region after shunting. Both T1 and T2 were almost the same in white and gray matter in shunt non-responders. It is suggested that the periventricular abnormalities seen in various diseases may be distinguished on the basis of the varying relaxation behavior of tissue water.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Bradley WG Jr, Waluch V, Brant-Zawadzki M, Yadley RA, Wycoff RR (1984) Patchy, periventricular white matter lesions in the elderly: A common observation during NMR imaging. Noninvas Med Imag 1: 35–41
Cooke R, Kuntz LD (1974) The properties of water in biological systems. Annu Rev Biophys Bioeng 3: 95–126
Furuse M, Gonda T, Inao S, Kuchiwaki H, Hirai N, Kageyama N (1987): Thermal analysis of water components in brain tissue. Quantitative determination of free and bound water fractions. No to Shinkei 39: 761–767
George AE, de Leon MJ, Kalnin A, Rosner L, Goodgold A, Chases N (1986) Leucoencephalopathy in normal and pathologic MRI of brain lucencies. AJNR 7: 567–570
Gerard G, Weisberg LA (1986) Magnetic resonance imaging in adult white matter disorders and hydrocephalus. Semin Neurol 6: 17–27
Go KG, Edzes HT (1975) Water in brain edema. Observations by the pulsed nuclear magnetic resonance technique. Arch Neurol 32: 462–465
Jack CR, Mokri B, Laws ER, Houser OW, Baker HL, Peterson RC (1987) MR findings in normal-pressure hydrocephalus: Significance and comparison with other forms of dementia. J Comput Assist Tomogr 11: 923–931
Kertesz A, Black SE, Tokar G, Benke T, Carr T, Nicholson L (1988) Periventricular and subcortical hyperintensities on magnetic resonance imaging. “Rims, caps, and unidentified bright objects”. Arch Neurol 45: 404–408
Pollay M, Curl F (1967) Secretion of cerebrospinal fluid by the ventricular ependyma of the rabbit. Am J Physiol 213: 1031–1038
Sze G, De Armond SJ, Brant-Zawadzki M, Davis RL, Norman D, Newton TH (1986) Foci of MRI signal (pseudo lesions) anterior to the frontal horns: Histologic correlations of a normal finding. AJNR 7: 381–387
Tamaki N, Shirakuni T, Kojima N, Masumura M, Matsumoto S (1985) Nuclear magnetic resonance study of periventricular edema in hydrocephalus. In: Inaba Y (ed) Brain edema. Springer, Berlin, pp 584–593
Tamaki N, Yamashita H, Kimura M, Ehara K, Asada M, Matsumoto S, Hashimoto M (1990) Changes in the components and content of biological water in the brain of experimental hydrocephalic rabbits. J Neurosurg 73: 274–278
Zimmerman RA, Fleming CA, Lee BCP, Saint-Louis LA, Deck MDF (1986) Periventricular hyperintensity as seen by magnetic resonance. Prevalence and significance. AJNR 7: 13–20
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Tokyo
About this paper
Cite this paper
Tamaki, N. et al. (1991). Properties of Interstitial Fluid in the Cerebral White Matter of Patients with Normal Pressure Hydrocephalus. In: Matsumoto, S., Tamaki, N. (eds) Hydrocephalus. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68156-4_60
Download citation
DOI: https://doi.org/10.1007/978-4-431-68156-4_60
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68158-8
Online ISBN: 978-4-431-68156-4
eBook Packages: Springer Book Archive