Abstract
The LEC rat has been established and characterized as a new mutant strain which spontaneously develops hepatitis and liver cancer at an extremely high incidence. The LEC rat manifests severe hereditary hepatitis with systemic jaundice and hemorrhagic tendency at around 4 months after birth. About 30%–40% of the rats die during the period of hepatitis because of submassive or massive necrosis of hepatocytes. The remaining rats recover from severe hepatitis and survive more than 1 year. Histopathological examination of the livers of the long-survived LEC rats shows development of preneoplastic and neoplastic lesions at a high incidence with continued hepatocyte death and regeneration (prolonged hepatitis) [1, 2].
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References
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© 1991 Springer-Verlag Tokyo
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Enomoto, K., Sawaki, M., Takahashi, H., Nakajima, Y., Dempo, K., Mori, M. (1991). The Multistep Nature of Spontaneous Liver Cancer Development in the LEC Rat: Analysis of Incidence and Phenotype of Preneoplastic and Neoplastic Liver Lesions. In: Mori, M., Yoshida, M.C., Takeichi, N., Taniguchi, N. (eds) The LEC Rat. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68153-3_32
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DOI: https://doi.org/10.1007/978-4-431-68153-3_32
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68155-7
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