Liver Diseases and Hepatic Sinusoidal Cells

1. Front Matter

   Pages II-XII

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2. Introduction

   1. Front Matter

      Pages 1-1

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   2. The Intestine, Spleen, and Liver

      • Kyuichi Tanikawa

      Pages 3-14

3. Hepatic Sinusoidal Cells: Characteristics and Special Topics

   1. Front Matter

      Pages 15-15

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   2. Endothelial Cells of the Hepatic Sinusoids: A Review

      • E. Wisse, F. Braet, D. Luo, D. Vermijlen, M. Eddouks, M. Konstandoulaki et al.

      Pages 17-53

   3. Hepatic Stellate Cells

      • Kenjiro Wake

      Pages 56-65

   4. Development, Differentiation, and Host Defense Function of Kupffer Cells

      • Makoto Naito, Go Hasegawa, Yusuke Ebe, Masao Mitsuyama

      Pages 66-75

   5. Pit Cells as Liver-Associated Natural Killer Cells

      • Kenji Kaneda

      Pages 76-87

4. Liver Diseases and Hepatic Sinusoidal Cells

   1. Front Matter

      Pages 89-89

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   2. Liver Injury and Regeneration

      1. Changes in Adhesion Molecules of Sinusoidal Endothelial Cells in Liver Injury

         • Hiromasa Ohira, Takato Ueno, Kyuichi Tanikawa, Reiji Kasukawa

         Pages 91-100

      2. The Role of Hepatic Sinusoidal Cells in the Development of Massive Liver Necrosis

         • Satoshi Mochida, Kenji Fujiwara

         Pages 101-113

      3. Sinusoidal Endothelial Cells in Liver Regeneration

         • Kenji Fujiwara, Satoshi Mochida

         Pages 114-123

      4. Angiogenesis of Cultured Rat Sinusoidal Endothelial Cells

         • Satoshi Shakado, Shotaro Sakisaka, Kazunori Noguchi, Michio Sata, Kyuichi Tanikawa

         Pages 124-127

      5. The Multiple Roles of Macrophages in Hepatic Granuloma Formation in Mice

         • Kiyoshi Takahashi, Motohiro Takeya, Kazuhisa Miyakawa, Sho-Ichiro Hagiwara, Aye Aye Wynn, Makoto Naito et al.

         Pages 128-140

   3. Hepatic Sinusoidal Microcirculation

      1. Roles of Sinusoidal Endothelial Cells in the Local Regulation of Hepatic Sinusoidal Blood Flow—Involvement of Endothelins and Nitric Oxide

         • Masaya Oda, Hiroaki Yokomori, Yoshitaka Kamegaya

         Pages 141-155

      2. Hepatic Innervation and Hepatic Sinusoidal Cells

         • Takato Ueno, Ryuichiro Sakata, Takuji Torimura, Seishu Tamaki, Masaharu Sakamoto, Kazuhisa Gondo et al.

         Pages 156-167

      3. Contraction and Relaxation of Ito Cells

         • Masaharu Sakamoto, Takato Ueno, Takuji Torimura, Seishu Tamaki, Motoaki Kin, Riko Ogata et al.

         Pages 168-177

      4. Portal Hypertension and the Hepatic Sinusoid

         • Don Rockey

         Pages 178-189

   4. Alcoholic Liver Diseases and Hepatic Sinusoidal Cells

      1. Role of Sinusoidal Endothelial Cells in Alcoholic Liver Disease

         • Takeshi Okanoue, Shinichi Sakamoto, Takashi Mori, Yoshihiko Sawa, Hikoharu Kanaoka, Kenichi Nishioji et al.

         Pages 190-198

      2. The Role of Neutrophils in Liver Cell Injury in Alcoholic Hepatitis

         • Ryukichi Kumashiro, Kazunori Noguchi, Shotaro Sakisaka, Kazuya Sato, Kunihide Ishii, Michio Sata et al.

         Pages 199-208

Hepatic sinusoidal cells such as sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, and pit cells play an important role in hemodynamic and metabolic function and are involved in various liver diseases. The frequent involvement of sinusoidal cells in pathologic conditions is explained by the diverse actions of those cells, an understanding of which is essential to clinicians. Generously illustrated, this volume presents results of recent studies on hepatic sinusoidal cells in liver diseases, with an introduction to the structure and function of the various types of sinusoidal cells. The in-depth focus of the book is on the role of hepatic sinusoidal cells in relation to liver injury and regeneration, hepatic sinusoidal microcirculation, alcoholic liver diseases, hepatic fibrosis, liver tumor, liver transplantation, cholestasis, and congenital lipidosis, thus providing a valuable reference source for practitioners and researchers.

• cell
• hepatitis
• liver
• liver disease
• liver transplantation
• liver tumor
• transplantation
• tumor
• hepatology

• Kurume University School of Medicine, Japan

  Kyuichi Tanikawa

• International Institute for Liver Research, Kurume Research Center, Kurume, Fukuoka, Japan

  Kyuichi Tanikawa

• The Second Department of Internal Medicine, Japan

  Takato Ueno

• Liver Cancer Research Division Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Kurume, Fukuoka, Japan

  Takato Ueno

Policies and ethics