Skip to main content

Anticonvulsants in Neuropsychiatry

  • Conference paper
Contemporary Neuropsychiatry
  • 230 Accesses

Abstract

The effects that antiepileptic drugs (AEDs) have on the neural membrane and on neurotransmitter receptors give these agents invaluable properties for treatment of a broad variety of neuropsychiatric disorders in addition to seizures and neuropathic pain [17]. Accordingly, AEDs should be more accurately considered as neuromodulatory drugs than strictly as anticonvulsants.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Beijamini V, Skalisz LL, Joca SR, Andreatini R (1998) The effect of oxcarbazepine on behavioural despair and learned helplessness. Eur J Pharmacol 347:23–27

    Article  PubMed  CAS  Google Scholar 

  2. Botts SR, Raskind J (1999) Gabapentin and lamotrigine in bipolar disorder. Am J Health Syst Pharm 56:1939–1944

    PubMed  CAS  Google Scholar 

  3. Bowden CL, Calabrese JR, Mc Elroy SL, et al (1999) The efficacy of lamotrigine in rapid cycling and non-rapid cycling patients with bipolar disorder. Biol Psychiatry 45:953–958

    Article  PubMed  CAS  Google Scholar 

  4. Cabras PL, Hardoy MJ, Hardoy MC, Carta MG (1999) Clinical experience with gabapentin in patients with bipolar or schizoaffective disorder: results of an open-label study. J Clin Psychiatry 60:245–248

    Article  PubMed  CAS  Google Scholar 

  5. Calabrese JR, Bowden CL, McElroy SL, et al (1999) Spectrum of activity of lamotrigine in treatment-refractory bipolar disorder. Am J Psychiatry 156:1019–1023

    PubMed  CAS  Google Scholar 

  6. Calabrese JR, Bowden CL, Sacks GS, et al (1999) A double-blind placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression: Lamictal 602 study group. J Clin Psychiatry 60:79–88

    Article  PubMed  CAS  Google Scholar 

  7. Calabrese JR, Rapport DJ, Kimmel SE, Shelton MD (1999) Controlled trials in bipolar I depression: focus on switch rates and efficacy. Eur Neuropsychopharmacol 9 (suppl 4):S109–S112

    Article  PubMed  CAS  Google Scholar 

  8. Calabrese JR, Rapport DJ, Shelton MD, et al (1998) Clinical studies on the use of lamotrigine in bipolar disorder. Neuropsychobiology 38:185–191

    Article  PubMed  CAS  Google Scholar 

  9. Chouinard G, Beauclair L, Belanger MC (1998) Gabapentin: long-term antianxiety and hypnotic effects in psychiatric patients with comorbid anxiety-related disorders. Can J Psychiatry 43:305

    PubMed  CAS  Google Scholar 

  10. Connor KM, Davidson JR, Sutherland S, Weisler R (1999) Social phobia: issues in assessment and management. Epilepsia 40 (suppl 6):S60–S65

    Article  PubMed  CAS  Google Scholar 

  11. Dilsaver SC, Swann SC, Chen Y.W., et al (1996) Treatment of bipolar depression with carbamazepine: results of an open study. Biol Psychiatry 40:935–937

    Article  PubMed  CAS  Google Scholar 

  12. Emrich HM, Dose M, von Zerssen D (1985) The use of sodium valproate, carbamazepine and oxcarbamazepine in patients with affective disorders. J Affect Disord 8:243–250

    Article  PubMed  CAS  Google Scholar 

  13. Erfurth A, Kammerer C, Grunze H, Normann C, Walden J (1998) An open label study of gabapentin in the treatment of acute mania. J Psychiatr Res 32:261–264

    Article  PubMed  CAS  Google Scholar 

  14. Ferrier IN (1998) Lamotrigine and gabapentin: alternative in the treatment of bipolar disorders. Neuropsychobiology 38:192–197

    Article  PubMed  CAS  Google Scholar 

  15. Gordon A, Price LH (1999) Mood stabilization and weight loss with topiramate [letter]. Am J Psychiatry 156:968–969

    PubMed  CAS  Google Scholar 

  16. Grunze H, Erfurth A, Amman B, et al (1999) Intravenous valproate loading in acutely manic and depressed bipolar I patients. J Clin Psychopharmacology 19:303–309

    Article  CAS  Google Scholar 

  17. Ketter TA, Post RM, Theodore WH (1999) Positive and negative psychiatric effects of antiepileptic drugs in patients with seizure disorders. Neurology 53 (5 suppl 2):S53–S67

    PubMed  CAS  Google Scholar 

  18. Kosten TR (1998) The pharmacotherapy of relapse prevention using anticonvulsants. Am J Addict 7:205–209

    PubMed  CAS  Google Scholar 

  19. Letterman L, Markowitz JS (1999) Gabapentin: a review of published experience in the treatment of bipolar disorder and other psychiatric conditions. Pharmacotherapy 19:565–572

    Article  PubMed  CAS  Google Scholar 

  20. Marcotte D (1998) Use of topiramate, a new anti-epileptic as a mood stabilizer. J Affect Disord 50:245–251

    Article  PubMed  CAS  Google Scholar 

  21. McElroy SL, Soutullo CA, Keck PE Jr, Kmetz GF (1997) A pilot trial of adjunctive gabapentin in the treatment of bipolar disorder. Ann Clin Psychiatry 9:99–103

    PubMed  CAS  Google Scholar 

  22. Normann C, Langosch J, Schaerer LO, et al (1999) Treatment of acute mania with topiramate [letter]. Am J Psychiatry 156:2014

    PubMed  CAS  Google Scholar 

  23. Pande AC, Davidson JR, Jefferson JW, et al (1999) Treatment of social phobia with gabapentin: a placebo-controlled study. J Clin Psychopharmacol 19:341–348

    Article  PubMed  CAS  Google Scholar 

  24. Perugi G, Toni C, Ruffolo G, et al (1999) Clinical experience using adjunctive gabapentin in treatment-resistant bipolar mixed states. Pharmacopsychiatry 32:136–141

    Article  PubMed  CAS  Google Scholar 

  25. Pinto OC, Akiskal HS (1998) Lamotrigine as a promising approach to borderline personality: an open case series without concurrent DSM-IV major mood disorder. J Affect Disord 51:333–334

    Article  PubMed  CAS  Google Scholar 

  26. Pollack MH, Matthews J, Scott EL (1998) Gabapentin as a potential treatment for anxiety disorders [letter]. Am J Psychiatry 155:992–993

    PubMed  CAS  Google Scholar 

  27. Post RM, Ketter TA, Denicoff K, et al (1996) The place of anticonvulsivant therapy in bipolar illness. Psychopharmacology (Berl) 128:115–129

    Article  CAS  Google Scholar 

  28. Sackellares JC, Berent S (1996) Psychological disturbances in epilepsy. Butterworth-Heinemann, Boston, 219–245

    Google Scholar 

  29. Schaffer CB, Schaffer LC (1999) Open maintenance treatment of bipolar disorder spectrum patients who responded to gabapentin augmentation in the acute phase of treatmen. J Affect Disord 55:237–240

    Article  PubMed  CAS  Google Scholar 

  30. Singh L, Field MJ, Ferris P, et al (1996) The antiepileptic agent gabapentin (Neurontin) possesses anxiolytic-like and antinociceptive actions that are reversed by D-serine. Psychopharmacology (Berl) 127:1–9

    Article  CAS  Google Scholar 

  31. Sokolski KN, Green C, Maris DE, DeMet EM (1999) Gabapentin as an adjunct to standard mood stabilizers in outpatients with mixed bipolar symptomatology. Ann Clin Psychiatry 11:217–222

    PubMed  CAS  Google Scholar 

  32. Suppes T, Brown ES, McElroy SL, et al (1999) Lamotrigine for the treatment of bipolar disorder: a clinical case series. J Affect Disord 53:95–98

    Article  PubMed  CAS  Google Scholar 

  33. Trimble MR (1998) New antiepileptic drugs and psychopathology. Neuropsychobiology 38:149–151

    Article  PubMed  CAS  Google Scholar 

  34. Watson WP, Robinson E, Little HJ (1997) The novel anticonvulsant, gabapentin, protects against both convulsant and anxiogenic aspects of the ethanol withdrawal syndrome. Neuropharmacology 36:1369–1375

    Article  PubMed  CAS  Google Scholar 

  35. Windhaber J, Maierhofer D, Dantendorfer K (1997) Oxcarbazepine for panic disorder occurring after two grand mal seizures: a case report [letter]. J Clin Psychiatry 58:404–405

    Article  PubMed  CAS  Google Scholar 

  36. Young LT, Robb JC, Hasey GM, et al (1999) Gabapentin as an adjunctive treatment in bipolar disorder. J Affect Disord 55:73–77

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer Japan

About this paper

Cite this paper

Gaviria, M., Medina, D. (2001). Anticonvulsants in Neuropsychiatry. In: Miyoshi, K., Shapiro, C.M., Gaviria, M., Morita, Y. (eds) Contemporary Neuropsychiatry. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67897-7_63

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-67897-7_63

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-67992-9

  • Online ISBN: 978-4-431-67897-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics