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Core 2 β6-N- Acetylglucosaminyltransferase-I and -III

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Handbook of Glycosyltransferases and Related Genes

Abstract

Core 2 β6-N-acetylglucosaminyltransferase (Core2GlcNAcT) is a glycosyltransferase that transfers GlcNAc from UDP-GlcNAc to αGalNAc residues in core 1, Galβ1- 3GalNAcα1-Ser/Thr with β1,6-linkage, forming Galβ1-3(GlcNAcβ1-6)GalNAcα1- Ser/Thr. The formation of the core 2 branch is usually followed by galactosylation by β4-galactosyltransferase-IV, a member of the β4-galactosyltransferase gene family (Ujita et al. 1998), resulting in the formation of N-acetyllactosamines in O-glycans. Such N-acetyllactosamines can be modified to form functional oligosaccharides such as sialyl Lewis X (Fig. 1).

The proposed biosynthetic pathways of O-glycans (A) and poly-N-acetyllactosaminyl O-glycans (B). A It has been shown that the tetrasaccharide (bottom left) is formed by the sequential action of α2-3-sialyltransferase followed by α2-6-sialyltransferase. When β6 Nacetylglucosaminyltransferase, Core2GlcNAcT, is present, the branched hexasaccharide (bottom right) is formed. B Poly-N-acetyllactosaminyl chain can be extended from the GlcNAcβ1,6- linkage synthesized in core 2. Poly-N-acetyllactosaminyl extension can be further modified by α3 fucosyltransferase, forming sialyl Lex termini. (From Maemura and Fukuda 1992)

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Author information

Authors and Affiliations

  1. Glycobiology Program, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Minoru Fukuda

  2. School of Dentistry, University of Copenhagen, 2200, Copenhagen N, Denmark

    Tilo Schwientek & Henrik Clausen

Authors
  1. Minoru Fukuda
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  2. Tilo Schwientek
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  3. Henrik Clausen
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Editor information

Editors and Affiliations

  1. Department of Biochemistry, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Naoyuki Taniguchi M.D., Ph.D. (Professor) & Koichi Honke M.D., Ph.D. (Associate Professor) (Professor) &  (Associate Professor)

  2. Glycobiology Program, Cancer Research Institute, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Minoru Fukuda Ph.D. (Professor) (Professor)

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© 2002 Springer Japan

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Fukuda, M., Schwientek, T., Clausen, H. (2002). Core 2 β6-N- Acetylglucosaminyltransferase-I and -III. In: Taniguchi, N., et al. Handbook of Glycosyltransferases and Related Genes. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67877-9_18

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  • DOI: https://doi.org/10.1007/978-4-431-67877-9_18

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-67996-7

  • Online ISBN: 978-4-431-67877-9

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