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A New Approach to the Treatment of Atopic Dermatitis: Antioxidant Vitamins and Atopic Dermatitis

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Food Factors for Cancer Prevention

Summary

Atopic dermatitis is a chronic inflammatory disorder that is frequently observed in affluent societies. An increased IgE in atopic dermatitis is a consequence of an imbalance between CD4+ T-cell subsets, T-helper-1 (Th1) and T-helper-2 (Th2). Atopic patients have more Th2 cells, which produce the interleukins (IL) IL-4, IL-5, IL-10, and IL-13, than Th2, which produces interferon-gamma (IFN-γ) and IL-2 in peripheral blood mononuclear cells. Recent investigations have suggested that decreased antioxidant defensive ability brings about a shift from the Th1 to the Th2-cytokine pattern, and this change may be reversible by supplementation with antioxidant vitamins, including vitamin C. However, little attention has been given to the treatment of atopic skin lesions with antioxidant vitamins. We therefore tried out a practical procedure for the treatment of atopic dermatitis and have observed highly effective improvement of severe atopic dermatitis within 4–6 months in many patients.

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Authors and Affiliations

  1. Department of Hygiene, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890, Japan

    Mitsuki Yoshioka, Koji Aoyama, Baohui Xu & Toshio Matsushita

  2. Dozono Obstetric and Gynecological Hospital, 3-1 Uenosono-cho, Kagoshima 890, Japan

    Haruhiko Dozono

Authors
  1. Mitsuki Yoshioka
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  2. Haruhiko Dozono
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  3. Koji Aoyama
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  4. Baohui Xu
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  5. Toshio Matsushita
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Editor information

Editors and Affiliations

  1. Department of Food Science and Technology Faculty of Agriculture, Kyoto University, Oiwake-cho, Kitashirakawa, Kakyo-ku, Kyoto, 606-01, Japan

    Hajime Ohigashi Ph.D. (Professor) (Professor)

  2. Department of Applied Biological Sciences Faculty of Agriculture, Nagoya University, Furocho, Chikusa-ku, Nagoya, Aichi, 464-01, Japan

    Toshihiko Osawa Ph.D. (Professor) (Professor)

  3. Lipid Science Laboratory, National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries, 2-1-2 Kannondai, Tsukuba, Ibaraki 305, Japan

    Junji Terao Ph.D. (Head) (Head)

  4. Nutrition and Epidemiology, Department of Agriculture, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156, Japan

    Shaw Watanabe M.D. (Professor) (Professor)

  5. First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602, Japan

    Toshikazu Yoshikawa M.D. (Associate Professor) (Associate Professor)

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© 1997 Springer Japan

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Yoshioka, M., Dozono, H., Aoyama, K., Xu, B., Matsushita, T. (1997). A New Approach to the Treatment of Atopic Dermatitis: Antioxidant Vitamins and Atopic Dermatitis. In: Ohigashi, H., Osawa, T., Terao, J., Watanabe, S., Yoshikawa, T. (eds) Food Factors for Cancer Prevention. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67017-9_79

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  • DOI: https://doi.org/10.1007/978-4-431-67017-9_79

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-67019-3

  • Online ISBN: 978-4-431-67017-9

  • eBook Packages: Springer Book Archive

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