Skip to main content
SpringerLink
Log in

New Polymeric Hydrogel Formulations for the Controlled Release of Proteic Drugs. DSC Investigation of Water Structure

  • Conference paper
Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems

  • 340 Accesses

Summary

New hybrid matrices with strong hydrogel characteristics were prepared by combination of partial esters of the alternating copolymers of maleic anhydride with mono-O-methyloligoethylenglycol vinyl ethers with α-interferon (IFNα) or myoglobin dispersed in human serum albumin. The matrices were used for the formulation of ocular inserts for the controlled release of IFNα. Kinetics of hydration, weight loss, and protein release as well as amount of bound water were investigated in simulated tear fluid. Results are discussed in terms of synthetic matrix/protein interactions.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Peptide and Protein Drug Delivery, V.H.L. Lee, Ed., Marcel Dekker Inc., New York (1991)

    Google Scholar 

  2. Stability of Protein Pharmaceuticals, Part A & B, T.J. Ahern and M.C. Manning, Eds., Plenum Press, New York (1992)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry and Industrial Chemistry, University of Pisa, via Risorgimento 35, 56126, Pisa, Italy

    E. E. Chiellini, E. Chiellini, D. Giannasi & R. Solaro

  2. Instituto de Quimica, Universidade de São Paulo, São Paulo, SP, Brazil

    E. Grillo Fernandes

Authors
  1. E. E. Chiellini
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Chiellini
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. Giannasi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. Grillo Fernandes
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. R. Solaro
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Chemistry, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, Tokyo, 102, Japan

    Naoya Ogata Ph.D. (Professor) (Professor)

  2. Center for Controlled Chemical Delivery, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, 84112, USA

    Sung Wan Kim Ph.D. (Professor and Director) (Professor and Director)

  3. Department of Chemical Technology and Institute of Biomedical Technology, University of Twente, P.O. Box 217, 7500 AD, Enschede, The Netherlands

    Jan Feijen Ph.D. (Professor) (Professor)

  4. Institute of Biomedical Engineering, Tokyo Women’s Medical College, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162, Japan

    Teruo Okano Ph.D. (Professor) (Professor)

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Tokyo

About this paper

Cite this paper

Chiellini, E.E., Chiellini, E., Giannasi, D., Fernandes, E.G., Solaro, R. (1996). New Polymeric Hydrogel Formulations for the Controlled Release of Proteic Drugs. DSC Investigation of Water Structure. In: Ogata, N., Kim, S.W., Feijen, J., Okano, T. (eds) Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems. Springer, Tokyo. https://doi.org/10.1007/978-4-431-65883-2_109

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-65883-2_109

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-65885-6

  • Online ISBN: 978-4-431-65883-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation