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Helicobacter pylori

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Glycoscience: Biology and Medicine

Abstract

Helicobacter pylori (H. pylori) is a microbe closely associated with pathogenesis of various gastric diseases, including chronic active gastritis and gastric cancer. Gastric gland mucin secreted from lower layer of the gastric mucosa characteristically contains O-glycans exhibiting terminal α1,4-linked GlcNAc residues (αGlcNAc). Cholesteryl-α-d-glucopyranoside (CGL) is a major component of the cell wall of Helicobacter species, including H. pylori, and is important for H. pylori survival. αGlcNAc suppresses CGL biosynthesis by inhibiting cholesterol α-glucosyltransferase (αCgT), which forms CGL; thus, αGlcNAc serves as a natural antibiotic against H. pylori infection in the stomach. Here, we summarize the protective functions of αGlcNAc against H. pylori and present an experimental protocol developed to test the effects of various glycans on H. pylori growth.

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Acknowledgments

We thank Dr. Elise Lamar for editing this manuscript.

Author information

Author notes

  1. Yuki Ito

    Present address: Department of Pathology, Ehime University Proteo-Science Center and Graduate School of Medicine, Shitsukawa 454, Toon, 791-0295, Japan

Authors and Affiliations

  1. Department of Molecular Pathology, Shinshu University Graduate School of Medicine, Asahi 3-1-1, Matsumoto, 390-8621, Japan

    Masatomo Kawakubo & Jun Nakayama

  2. Cancer Center, Sanford-Burnham Medical Research Institute, 10901 North Pines Road, La Jolla, Torrey, CA, 92037, USA

    Yuki Ito

  3. Cancer Center, Sanford-Burnham Medical Research Institute, 10901 North Pines Road, La Jolla, La Jolla, CA, 92037, USA

    Minoru Fukuda

Authors
  1. Masatomo Kawakubo
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  2. Yuki Ito
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  3. Minoru Fukuda
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  4. Jun Nakayama
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Corresponding author

Correspondence to Jun Nakayama .

Editor information

Editors and Affiliations

  1. Systems Glycobiology Research Group, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, Wako, Saitama, Japan

    Naoyuki Taniguchi

  2. Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan

    Tamao Endo

  3. Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Gerald W. Hart

  4. Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany

    Peter H. Seeberger

  5. Academica Sinica, NanKang, T´ai-pei, Taiwan

    Chi-Huey Wong

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© 2015 Springer Japan

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Kawakubo, M., Ito, Y., Fukuda, M., Nakayama, J. (2015). Helicobacter pylori . In: Taniguchi, N., Endo, T., Hart, G., Seeberger, P., Wong, CH. (eds) Glycoscience: Biology and Medicine. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54841-6_145

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