Abstract
O-GlcNAcylation, which is the cycling of N-acetylglucosamine (GlcNAc) on nuclear and cytosolic proteins, has extensive cross talk with phosphorylation to serve as a nutrient sensor that regulates nearly all aspects of cellular metabolism. O-GlcNAc cycling is tightly regulated by only two gene products, O-GlcNAc transferase and O-GlcNAcase that are targeted to substrates by a multitude of binding partners. Research over the past three decades has shown that O-GlcNAcylation is fundamentally important in regulating transcription, modulating signaling pathways, and modifying the activities of metabolic enzymes and kinases in response to nutrients.
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Hart, G.W. (2014). O-GlcNAcylation: A Nutrient Sensor That Regulates Cell Physiology. In: Endo, T., Seeberger, P., Hart, G., Wong, CH., Taniguchi, N. (eds) Glycoscience: Biology and Medicine. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54836-2_82-1
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DOI: https://doi.org/10.1007/978-4-431-54836-2_82-1
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Publisher Name: Springer, Tokyo
Online ISBN: 978-4-431-54836-2
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