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Intracellular Lectin, ERGIC-53

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Glycoscience: Biology and Medicine

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Abstract

The endoplasmic reticulum (ER)–Golgi intermediate compartment (ERGIC) 53-kDa protein (ERGIC-53) is a cargo receptor for the transport of nascent proteins from the ER through the ERGIC to the Golgi in cells. ERGIC-53 has an L-type lectin domain in luminal part, and sugar-binding activity is required for the transport of cargo proteins. In the ER, another protein named MCFD2 is associated with ERGIC-53, which plays important roles in sophisticated function of ERGIC-53. In this chapter, I will describe functional roles of ERGIC-53 in the cell based on its biochemical properties.

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Authors and Affiliations

  1. Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwanoha 5-1-5, Kashiwa, Chiba, 277-8562, Japan

    Kazuo Yamamoto

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  1. Kazuo Yamamoto
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Correspondence to Kazuo Yamamoto .

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Editors and Affiliations

  1. Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan

    Tamao Endo

  2. Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany

    Peter H. Seeberger

  3. Dept. Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Gerald W. Hart

  4. Academia Sinica, Nankang, Taipei, Taiwan

    Chi-Huey Wong

  5. Systems Glycobiology Group, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, Wako, Saitama, Japan

    Naoyuki Taniguchi

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© 2014 Springer Japan

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Yamamoto, K. (2014). Intracellular Lectin, ERGIC-53 . In: Endo, T., Seeberger, P., Hart, G., Wong, CH., Taniguchi, N. (eds) Glycoscience: Biology and Medicine. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54836-2_46-1

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  • DOI: https://doi.org/10.1007/978-4-431-54836-2_46-1

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  • Publisher Name: Springer, Tokyo

  • Online ISBN: 978-4-431-54836-2

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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