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Glycans Against NK Tumor Immunity

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Glycoscience: Biology and Medicine

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Abstract

O-glycans are the cell-surface carbohydrates attached to membrane proteins through serine (Ser) or threonine (Thr). Recently, extensive investigation on O-glycans in cancer cells has revealed that there is a certain type of O-glycan that can promote cancer cell metastasis. Cancer cells expressing the O-glycans called core2 O-glycans exhibit a high ability to evade host tumor rejection systems by natural killer (NK) cells. Evasion from the NK tumor rejection systems by using core2 O-glycans facilitates the cancer cells to survive longer in host circulation. Core2 O-glycans expressing cancer cells thus increase the chance to invade other organs, thereby resulting in the promotion of metastasis. In this chapter, it is illustrated how core2 O-glycans in cancer cells evade host immune systems to promote metastasis.

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References

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Authors and Affiliations

  1. Department of Cancer Immunology and Cell Biology, Oyokyo Kidney Research Institute, 90 Kozawa Yamazaki, Hirosaki, Aomori, 036-8243, Japan

    Shigeru Tsuboi

Authors
  1. Shigeru Tsuboi
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Correspondence to Shigeru Tsuboi .

Editor information

Editors and Affiliations

  1. Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan

    Tamao Endo

  2. Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany

    Peter H. Seeberger

  3. Dept. Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Gerald W. Hart

  4. Academia Sinica, Nankang, Taipei, Taiwan

    Chi-Huey Wong

  5. Systems Glycobiology Group, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, Wako, Saitama, Japan

    Naoyuki Taniguchi

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© 2014 Springer Japan

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Tsuboi, S. (2014). Glycans Against NK Tumor Immunity. In: Endo, T., Seeberger, P., Hart, G., Wong, CH., Taniguchi, N. (eds) Glycoscience: Biology and Medicine. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54836-2_190-1

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  • DOI: https://doi.org/10.1007/978-4-431-54836-2_190-1

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  • Publisher Name: Springer, Tokyo

  • Online ISBN: 978-4-431-54836-2

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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