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Management for Massive Hemorrhage During Surgery

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Neuroanesthesia and Cerebrospinal Protection
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Abstract

Although the incidence of massive hemorrhage during surgery is low, the prognosis of massive hemorrhage is poor. When we encounter massive hemorrhage, systematic approach is mandatory. Physicians, nurses, and technicians at the scene, staff in the transfusion department, and the staff in the blood center work as a team. Achieving hemostasis by surgical maneuvers and restoration of blood volume to maintain organ perfusion and oxygenation is essential. If the patient requires vasopressors and lack of crossmatched red cell concentrate (RCC), type-specific RCC should be used. When the situation is life-threatening, un-crossmatched type-compatible RCC should be used. To correct coagulopathy, judicious use of blood components such as fresh frozen plasma and platelet concentrates is mandatory. It may require cryoprecipitate, a fibrinogen product, when fibrinogen level is very low. To improve patient’s outcome, understanding of current blood transfusion guidelines and institutional simulation is important.

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References

  1. Inada E, Irita K, Tsuzaki K, Kino S, Inaba S (2009) Strategies for blood transfusion in critical bleeding. ISBT Sci Ser 4:161–166

    Article  Google Scholar 

  2. Kawashima Y, Seo N, Morita K et al (2002) Anesthesia-related mortality and morbidity in Japan (1999). J Anesth 16:319–331

    Article  PubMed  Google Scholar 

  3. Kawashima Y, Takahashi S, Suzuki M et al (2003) Anesthesia-related mortality and morbidity over a 5-year period in 2,363,038 patients in Japan. Acta Anaesthesiol Scand 47:809–817

    Article  CAS  PubMed  Google Scholar 

  4. Irita K, Kawashima Y, Morita K, Seo N, Iwao Y et al (2005) Supplemental survey in 2003 concerning life-threatening hemorrhagic events in the operating room. Masui 54:77–86

    PubMed  Google Scholar 

  5. Kawashima Y, Seo N, Tsuzaki K, Iwao Y, Morita K, Irita K, Obara H (2003) Annual study of anesthesia-related mortality and morbidity in the year 2001 in Japan: the outlines–report of Japanese Society of Anesthesiologists Committee on Operating Room Safety. Masui 52:666–682

    PubMed  Google Scholar 

  6. The Albumin Reviewers (Alderson P, Bunn F, Lefebvre C, Li Wan Po A, Li L, Roberts I, Schierhout G (1999) Human albumin administration in critically ill patients. In: The Cochrane Library, Issue 1. Update Software, Oxford

    Google Scholar 

  7. The SAFE Study Investigators (2004) A comparison of albumin and saline for fluid resuscitation in the Intensive Care Unit. N Engl J Med 350:2247–2256

    Article  Google Scholar 

  8. The SAFE Study Investigators (2007) Saline or albumin for fluid resuscitation in patients with traumatic brain injury. N Engl J Med 357:874–884

    Article  Google Scholar 

  9. The American Society of Anesthesiologists Task Force on Perioperative Blood Transfusion and Adjuvant Therapies (2006) Practice guidelines for perioperative blood transfusion and adjuvant therapies. Anesthesiology 105:198–208

    Article  Google Scholar 

  10. Hippala ST, Myllyla GJ, Vahtera EM (1995) Hemostatic factors and replacement of major blood loss with plasma-poor red cell concentrates. Anesth Analg 81:360–365

    Google Scholar 

  11. Reiss RF (2000) Hemostatic defects in massive blood transfusion: rapid diagnosis and management. Am J Crit Care 9:158–165

    CAS  PubMed  Google Scholar 

  12. Clark AD, Gordon WC, Walker ID et al (2004) “Last-ditch” use of recombinant factor VIIa in patients with massive hemorrhage is ineffective. Vox Sang 86:120–124

    Article  CAS  PubMed  Google Scholar 

  13. Johansson PI (2008) Off-label use of recombinant factor VIIa for treatment of haemorrhage; results from randomized clinical trials. Vox Sang 95:1–7

    Article  CAS  PubMed  Google Scholar 

  14. Miyao H, Shimizu K, Kawazoe T (2000) A review of correlation between transfusion rate of irradiated blood and potassium load. Masui 49:383–390

    CAS  PubMed  Google Scholar 

  15. Rajagopalan S, Mascha E, Na J et al (2008) The effects of mild perioperative hypothermia on blood loss and transfusion requirement. Anesthesiology 108:71–77

    Article  PubMed  Google Scholar 

  16. Smith HM, Farrow SJ, Ackerman JD et al (2008) Cardiac arrest associated with hyperkalemia during red blood cell transfusion: a case series. Anesth Analg 106:1062–1069

    Article  PubMed  Google Scholar 

  17. Irita K, Inada E, Yoshimura H, Warabi K, Tsuzaki K, Inaba S, Handa M, Uemura T, Kino S, Mashiko K, Yano T, Kamei Y, Kubo T (2009) Present status of preparatory measures for massive hemorrhage and emergency blood transfusion in regional hospitals with an accredited department of anesthesiology in 2006. Masui 58:109–123

    PubMed  Google Scholar 

  18. Inada E (2008) Annual report of the study supported by the Grant of the Ministry of Health, Labour and Welfare (H.19-IYAKU-General-031)

    Google Scholar 

  19. http://www.anesth.or.jp/med/pdf/kikitekisyukketsu2012.pdf

  20. Cotton BA, Au BK, Nunez TC et al (2009) Predefined massive transfusion protocols are associated with a reduction in organ failure and postinjury complications. J Trauma 66:41–49

    Article  PubMed  Google Scholar 

  21. Stinger H, Spinella P, Perkins J et al (2008) The ratio of fibrinogen to red cells transfused affects survival in casualties receiving massive transfusions at an army combat support hospital. J Trauma 64:S79–S85

    Article  CAS  PubMed  Google Scholar 

  22. Borgman M, Spinella P, Perkins J et al (2007) The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital. J Trauma 63:805–813

    Article  PubMed  Google Scholar 

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Acknowledgment

This article is supported by the Grant of the Ministry of Health, Labour and Welfare (H.19-Iyaku-General-031 and H.24-Iyaku-General-005).

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Correspondence to Eiichi Inada M.D. .

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© 2015 Springer Japan

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Inada, E. (2015). Management for Massive Hemorrhage During Surgery. In: Uchino, H., Ushijima, K., Ikeda, Y. (eds) Neuroanesthesia and Cerebrospinal Protection. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54490-6_44

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  • DOI: https://doi.org/10.1007/978-4-431-54490-6_44

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-54489-0

  • Online ISBN: 978-4-431-54490-6

  • eBook Packages: MedicineMedicine (R0)

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