Abstract
There has been a renewal of interest in controlling biological events and a considerable number of studies have been conducted on designing of novel materials to meet these applications. Some special types of polymers, for example, have emerged as a very useful class of polymers and have their own special chemical properties and applications in various areas. These polymers are called “smart polymers”. The characteristic feature that actually makes them smart is their ability to respond to very slight changes in the surrounding environment. The uniqueness of these materials lies not only in the fast macroscopic changes occurring in their structure but also these transitions being reversible. This chapter introduces a novel functionalization method of isopropylacrylamide-type monomers and their polymers, which have been studies most extensively. Use of these monomers can synergistically combine the individual properties of the two or more components to yield new and desirable properties.
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References
English AE, Tanaka T, Edelman ER (1997) Equilibrium and non-equilibrium phase transitions in copolymer polyelectrolyte hydrogels. J Chem Phys 107:1645–1654
Hoffman AS, Stayton PS, Bulmus V, Chen G, Chen J, Cheung C, Chilkoti A, Ding Z, Dong L, Fong R, Lackey CA, Long CJ, Miura M, Morris JE, Murthy N, Nabeshima Y, Park TG, Press OW, Shimoboji T, Shoemaker S, Yang HJ, Monji N, Nowinski RC, Cole CA, Priest JH, Harris JM, Nakamae K, Nishino T, Miyata T (2000) Really smart bioconjugates of smart polymers and receptor proteins. J Biomed Mater Res 52:577–586. doi:10.1002/1097-4636(20001215)52:4<577:aid-jbm1>3.0.co;2-5
Yamada N, Okano T, Sakai H, Karikusa F, Sawasaki Y, Sakurai Y (1990) Thermo-responsive polymeric surfaces; control of attachment and detachment of cultured cells. Die Makromol Chem, Rapid Commun 11:571–576. doi:10.1002/marc.1990.030111109
Xue W, Champ S, Huglin MB (2000) Observations on some copolymerisations involving N-isopropylacrylamide. Polymer 41:7575–7581. http://dx.doi.org/10.1016/S0032-3861(00)00171-3
Aoyagi T, Ebara M, Sakai K, Sakurai Y, Okano T (2000) Novel bifunctional polymer with reactivity and temperature sensitivity. J Biomater Sci Polym Ed 11:101–110. doi:10.1163/156856200743526
Kanda T, Yamamoto K, Aoyagi T (2005) N-Isopropylacrylamide-based temperature-responsive polymer with carboxyl groups for controlled drug release. J Photopolym Sci Technol 18:515–518
Yoshida T, Aoyagi T, Kokufuta E, Okano T (2003) Newly designed hydrogel with both sensitive thermo response and biodegradability. J Polym Sci, Part A: Polym Chem 41:779–787. doi:10.1002/pola.10595
Maeda T, Kanda T, Yonekura Y, Yamamoto K, Aoyagi T (2006) Hydroxylated poly(N-isopropylacrylamide) as functional thermoresponsive materials. Biomacromolecules 7:545–549. doi:10.1021/bm050829b
Maeda T, Yamamoto K, Aoyagi T (2006) Importance of bound water in hydration–dehydration behavior of hydroxylated poly(N-isopropylacrylamide). J Colloid Interface Sci 302:467–474. http://dx.doi.org/10.1016/j.jcis.2006.06.047
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© 2014 National Institute for Materials Science, Japan. Published by Springer Japan
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Ebara, M. et al. (2014). Introductory Guide to Smart Biomaterials. In: Smart Biomaterials. NIMS Monographs. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54400-5_1
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DOI: https://doi.org/10.1007/978-4-431-54400-5_1
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