Abstract
We explore the D-optimal design for a five-parameter logistic model, which includes a shape parameter to handle asymmetries, and two threshold parameters to account for situations where the asymptotes are not at 0 and 1. The optimal design is five points, including points at -∞ and ∞ representing the thresholds. We compare the efficiencies of the optimal designs arising from the two- and five- parameter models. We find a significant loss of efficiency when the two-parameter model is used on data generated from the five-parameter model.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Atkinson, A. C., A.N. Donev, and R. D. Tobias (2007). Optimum Experimental Designs, with SAS. Oxford: Oxford University Press.
Biedermann, S., H. Dette, and A. Pepelyshev (2006). Some robust design strategies for percentile estimation in binary response models. Canadian Journal of Statistics 34, 603–622.
Haines, L. M., I. Perevozskaya, and W. F. Rosenberger (2003). Bayesian optimal designs for Phase I clinical trials. Biometrics 59, 591–600.
Kalish, L. A. and J. L. Rosenberger (1978). Optimal designs for the estimation of the logistic function. Technical Report 33, Pennsylvania State University.
Kiefer, J. and J. Wolfowitz (1960). The equivalence of two extremum problems. Canadian Journal of Mathematics 12, 363–366.
Manukyan, Z. (2009). Sequential Designs for Estimating Toxicity and Efficacy in a Dose-Response Setting. Ph. D. thesis, George Mason University.
Acknowledgements
The authors thank two excellent referees for their detailed comments. One of the referees found a major mistake, and the authors are deeply appreciative.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Manukyan, Z., Rosenberger, W.F. (2010). D-Optimal Design for a Five-Parameter Logistic Model. In: Giovagnoli, A., Atkinson, A., Torsney, B., May, C. (eds) mODa 9 – Advances in Model-Oriented Design and Analysis. Contributions to Statistics. Physica-Verlag HD. https://doi.org/10.1007/978-3-7908-2410-0_15
Download citation
DOI: https://doi.org/10.1007/978-3-7908-2410-0_15
Published:
Publisher Name: Physica-Verlag HD
Print ISBN: 978-3-7908-2409-4
Online ISBN: 978-3-7908-2410-0
eBook Packages: Mathematics and StatisticsMathematics and Statistics (R0)