Abstract
Response-adaptive designs may be used in phase III clinical trials to allocate a larger number of patients to the better treatment. Optimal response-adaptive designs are used for the same purpose, but the design is derived from some optimal points of view. The available optimal response-adaptive designs are only for two treatment trials. In the present paper, we extend this idea and derive some optimal response-adaptive designs for phase III clinical trials for more than two treatments. In particular, we work on three treatments. The extension is not trivial, as the designs for three treatments are often iterative, and they need specific algorithms for computation. The proposed approaches are numerically illustrated.
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Biswas, A., Mandal, S. (2007). Optimal Three-Treatment Response-Adaptive Designs for Phase III Clinical Trials with Binary Responses. In: López-Fidalgo, J., RodrÃguez-DÃaz, J.M., Torsney, B. (eds) mODa 8 - Advances in Model-Oriented Design and Analysis. Contributions to Statistics. Physica-Verlag HD. https://doi.org/10.1007/978-3-7908-1952-6_5
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DOI: https://doi.org/10.1007/978-3-7908-1952-6_5
Publisher Name: Physica-Verlag HD
Print ISBN: 978-3-7908-1951-9
Online ISBN: 978-3-7908-1952-6
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