Summary
Recently, the use of smell in clinical diagnosis has been rediscovered due to major advances in odour sensing technology and artificial intelligence. It was well known that a number of infectious or metabolic diseases could liberate specific odours characteristic of the disease stage and among others, urine volatile compounds have been identified as possible diagnostic markers. A newly developed “artificial nose” based on chemoresistive sensors has been employed to identify in vivo urine samples from 45 patients with suspected uncomplicated UTI who were scheduled for microbiological analysis in a UK Public Health Laboratory environment. An intelligent model consisting of an odour generation mechanism, rapid volatile delivery and recovery system, and a classifier system based on a hybrid system of genetic algorithms, neural networks and multivariate techniques such as principal components analysis and discriminant function analysis-cross validation. The experimental results confirm the validity of the presented method.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Gibson, T.D., Hulbert, J.N, Prosser, O.C., Pavlou A.K (2000), Not to be sniffed at. Microbiology Today. 27, 1, 14–17.
Persaud, K., Dodd, G.H. (1982), Analysis of discrimination mechanisms of the mammalian olfactory system using a model nose. Nature. 299, 352–355.
Gopel, W. (1998), Chemical Imaging: I. Concepts and Visions for Electronic and Bioelectronic Noses. Sensors & Actuators B. 52, 125–142.
Gardner, J•W., Shin, H.W., Hines, E.L. (2000), An electronic nose system to diagnose illness. Sensors & Actuators B. 70, 19–24.
Davies, T., Hayward, N.J. (1984), Volatile products from acetylcholine are markers in the rapid urine test using headspace gas liquid chromatography. J. Chromatography. 307, 111–121.
Parry, A.D. (1995), Leg ulcer odour detection identifies b-haemolytic streptococcal infection. J Wound Care. 4, 404.
Hanson III, C.W., Steinberger H.A. (1997), The use of a novel electronic nose to diagnose the presence of intrapulmonary infection. Anaesthesiology. 87, 3A, 269.
Pavlou A.K., Kodogiannis V.S., Turner A.P.F. (2001), Intelligent classification of bacterial clinical isolates in vitro, using electronic noses. Int. Conf. on Neural Net. & Expert Systems in Medicine and HealthCare, Milos Isl., Greece, 231–237.
Richards M.J., Edwards J.R., Culver D.H., Gaynes R.P. (1999), Nosocomial infections in medical intensive care units in the United States. National nosocomial infections surveillance system. Crit Care Med. 27, 887–892.
Zlatkis A, Brazell R.S, Poole C.F. (1981), The role of organic volatile profiles in clinical diagnosis. Clin Chem. 27, 789–797.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Kodogiannis, V.S., Pavlou, A.K., Chountas, P., Turner, A.P.F. (2003). Evolutionary Computing Techniques for Diagnosis of Urinary Tract Infections in Vivo, Using Gas Sensors. In: Rutkowski, L., Kacprzyk, J. (eds) Neural Networks and Soft Computing. Advances in Soft Computing, vol 19. Physica, Heidelberg. https://doi.org/10.1007/978-3-7908-1902-1_72
Download citation
DOI: https://doi.org/10.1007/978-3-7908-1902-1_72
Publisher Name: Physica, Heidelberg
Print ISBN: 978-3-7908-0005-0
Online ISBN: 978-3-7908-1902-1
eBook Packages: Springer Book Archive