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Hepatitis A virus, TIM-1 and allergy

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The Hygiene Hypothesis and Darwinian Medicine

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

In 1989, Strachan first proposed the hygiene hypothesis to explain the rapid increase in the prevalence of allergy and asthma. While the significant rise in the prevalence of asthma and allergy remains unexplained, epidemiological data suggest that infection with the Hepatitis A virus (HAV) might protect against asthma and allergy, and genetic studies identifying the HAV receptor, TIM-1, as an important atopy susceptibility gene, support this idea. In this chapter, we review the genetics and immunobiology of TIM-1 and TIM gene family members, and the possibility that HAV and TIM-1 may regulate the development of asthma and allergy.

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Authors and Affiliations

  1. Harvard Medical School, Children’s Hospital Boston, One Blackfan Circle, Boston, MA, 02115, USA

    Dale T. Umetsu & Rosemarie H. DeKruyff

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  1. Dale T. Umetsu
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  2. Rosemarie H. DeKruyff
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Editors and Affiliations

  1. Centre for Infectious Diseases and International Health Windeyer Institute for Medical Sciences, University College London, 46 Cleveland Street, London, W1T 4JF, UK

    Graham A. W. Rook

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Umetsu, D.T., DeKruyff, R.H. (2009). Hepatitis A virus, TIM-1 and allergy. In: Rook, G.A.W. (eds) The Hygiene Hypothesis and Darwinian Medicine. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8903-1_4

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