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Interleukin 17

  • Reference work entry
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Compendium of Inflammatory Diseases

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Synonyms

IL-17/IL-17A/CTLA-8

Definition

“Interleukin-17” (IL-17A) is a commonly used colloquial term referring to the cytokine IL-17A. IL-17A is the defining cytokine of the IL-17 cytokine family, which is constituted by the six cytokines IL-17A, IL-17B, IL-17C, IL-17D, IL-17E, and Il-17F. All IL-17 cytokines consist of two single glycoprotein chains forming homo- or heterodimers linked via disulfide bonds. The complete IL-17A dimer is composited by of 155 amino acids and weighs 35 kDa. In addition to IL-17A and IL-17F homodimers, IL-17A and IL-17F chains can also combine to IL-17A/F heterodimers, which are biologically active (Wright et al. 2007).

IL-17A was the first member of the IL-17 cytokine family described. Its sequence was discovered in 1993 in hybridoma cells emerging from fusion of murine cytotoxic T cells with a rat T lymphoma cell line, which had been stimulated with combination of PMA and ionomycin (Rouvier et al. 1993). The product had first been designated as cytotoxic...

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Authors and Affiliations

  1. Department of Dermatology, Allergy, and Venereology, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany

    Christian D. Sadik

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  1. Christian D. Sadik
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Correspondence to Christian D. Sadik .

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Editors and Affiliations

  1. Fraunhofer IME-TMP & JW Goethe University Frankfurt, Frankfurt am Main, Germany

    Michael J. Parnham

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Sadik, C.D. (2016). Interleukin 17. In: Parnham, M.J. (eds) Compendium of Inflammatory Diseases. Springer, Basel. https://doi.org/10.1007/978-3-7643-8550-7_84

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