Synonyms
Boecks sarcoidosis; Heerfordt’s syndrome; Lofgren’s syndrome; Lupus pernio
Definition
Sarcoidosis is a multisystemic inflammatory disease characterized by the presence of noncaseating granulomas. In order to make the diagnosis, all other causes of granulomas must be excluded and the patient must have the appropriate clinical presentation.
Epidemiology and Genetics
Sarcoidosis is a worldwide disease. However, the incidence of the disease varies, with some ethnic groups such as Nordic and African Americans have an increased rate of disease (Hall et al. 1969). In Japan, the disease is more frequent in northern climates and in Europe, Scandinavian countries have significantly more disease than more southern areas, such as Italy and Greece. In the USA, however, the southeastern area has a higher frequency than that reported in the northwest or the Rocky Mountain States.
In addition to geographic variation, there is a variation of the manifestations of the disease based on genetic...
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Baughman, R.P. (2016). Sarcoidosis. In: Parnham, M.J. (eds) Compendium of Inflammatory Diseases. Springer, Basel. https://doi.org/10.1007/978-3-7643-8550-7_72
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