Summary
Based on the rewarding effect of septal area, therapeutic Stimulation of this region has been applied to surgical management of chronic pain. However some basic problems of this technique remain unsolved. Thus the effect of septal Stimulation was tested on an experimental model of painful and symbolic stress, comparing the variations in the pituitaryadrenal axis activity, the peripheral cathecolamine levels and the structural changes in gastric mucosa and adrenal glands, between the problem and different control groups. The bioelectrical activity of septal area and antexolateral hypothalamus during Stimulation were recorded. A decrease in gastric ulceration and plasma cortisol were observed in the septal stimulation group. No direct influence on the cathecolaminic system was noted. A facilitation of septal activity and its influence on hypothalamic rythm were found. All these effects were mainly achieved in the posterior perifornical septal region.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Adami, E., Pharmacological research on generfate, a new synthetic isoprenoid with antiulcer action. Arch. Intern. Pharmacodyn.147 (1974), 113–117.
Gol, A., Relief of pain by electrical Stimulation of the septal area. J. Neurol. Sci.5 (1967), 115–120.
Heath, R. G., Mickle, W. A., Evaluation of seven years’ experience with depth electrode studies in human patients. In: Electrical studies on the unanaesthetized brain (Ramey, E. R., O’Doherty, D. S., eds.). New York: Hoeber. 1960.
Obrador, S., Delgado, J. M. R., Martin-Rodriguez, J. G., Emotional areas of the human brain and their therapeutical Stimulation. In: Cerebral localization, pp. 171–183 (Zülch, K. J., et al., eds.). Berlin-Heidelberg-New York: Springer. 1975.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 Springer-Verlag
About this paper
Cite this paper
Broseta, J., Barcia-Salorio, J.L., Barberá, J. (1980). Septal Stimulation on Painful and Symbolic Stress. Experimental Study. In: Gillingham, F.J., Gybels, J., Hitchcock, E., Rossi, G.F., Szikla, G. (eds) Advances in Stereotactic and Functional Neurosurgery 4. Acta Neurochirurgica Supplementum, vol 30. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8592-6_33
Download citation
DOI: https://doi.org/10.1007/978-3-7091-8592-6_33
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-81591-5
Online ISBN: 978-3-7091-8592-6
eBook Packages: Springer Book Archive