Abstract
Tetracyclines inhibit ribosomal functions. From the observed interference of the antibiotics with initiation and elongation steps in cell-free systems of peptide synthesis, it was concluded that tetracyclines block the A-site of the 30S ribosomal subunit (see Pestka, 1971, for summarizing references).
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References
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Kersten, H. (1975). Binding of Tetracyclines and Other Antibiotics to Ribosomes. In: Drews, J., Hahn, E. (eds) Drug Receptor Interactions in Antimicrobial Chemotherapy. Topics in Infectious Diseases, vol 1. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8405-9_11
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DOI: https://doi.org/10.1007/978-3-7091-8405-9_11
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