Summary
The aim of the present study was to utilize an experimental traumatic subarachnoidal hemorraghe model in the developing rat.
Diffuse brain injury was produced in intubated and ventilated 21 to 25 days old Sprague-Dawley rats (N = 10) using a modification (1 m/100 g) of the Marmarou-model. Before induction of the injury heparin was administered i.v. and antagonised after injury by protamine. Mean arterial blood pressure and intracranial pressure was measured continuously. Histopathological investigations were performed. The results were compared to readings in adult animals (N = 12) subjected to a 1.5 m/500 g injury.
In the developing rat ICP increased immediately following injury from 11.4 ± 2.1 mm Hg to 55.9 ± 20.3 mm Hg. It remained elevated till the end of the experiment 1 h after injury. MABP increased from 79.8 ± 8.7 mm Hg to 100.2 ± 21.7 mm Hg immediately following injury, returning to 61.3 ± 28.7 mm Hg at the end of the experiment resulting in a marked decrease of CPP. The mortality rate was 60%. All brains showed a severe subarachnoidal hemorrhage in the basal cisterns.
The increase of ICP following injury is attributable to the bleeding similar as in adult animals. The high mortality is due to the marked decrease of CPP. Rat pups are more vulnerable to t-SAH compared to adult rats.
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References
Aldrich EF, Eisenberg HM, Saydjari C, Luerssen TG, Foulkes MA, Jane JA, Marshall LF, Young H (1992) Diffuse brain swelling in severely head-injured children. A report from the NIH Traumatic Coma Data Bank. J Neurosurg 76: 450-454
Eisenberg HM, Gary HE, Aldrich EF et al (1990) Initial CT findings in 753 patients with severe head injury. A report from the NIH Traumatic Coma Data Bank. J Neurosurg 73: 688–698
Kakarieka A (1997) Traumatic subarachnoidal haemorrhage. Springer, Berlin Heidelberg New York Tokyo
Kennard MA (1936) Age and other factors in motor recovery from precentral lesions in monkeys. Am J Physiol 115–138
Marmarou A, Foda MAA, Van den Brink W, Campbell J, Kita H, Demetriadou K (1994) A new model of diffuse brain injury in rats. Part I: pathophysiology and biomechanics. J Neurosurg 80: 291–300
Thomas S, Tabibnia F, Schuhmann MU, Hans VHJ, Brinker T, Samii M (1998) Traumatic brain injury in the developing rat pup: studies of ICP, PVI and neurological response. Acta Neurochir (Wien)[Suppl]71: 135–137
Thomas S, Tabibnia F, Herrmann B, Schuhmann MU, Brinker T, Samii M (1999) Traumatic subarachnoidal hemorrhage: Introduction of a new experimental model in the rat. J Neuro-trauma 16: 959
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Thomas, S., Tabibnia, F., Herrmann, B., Schuhmann, M.U., Brinker, T., Samii, M. (2002). Traumatic Subarachnoidal Hemorrhage in the Developing Rat. In: Czosnyka, M., Pickard, J.D., Kirkpatrick, P.J., Smielewski, P., Hutchinson, P. (eds) Intracranial Pressure and Brain Biochemical Monitoring. Acta Neurochirurgica Supplements, vol 81. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6738-0_64
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DOI: https://doi.org/10.1007/978-3-7091-6738-0_64
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