Summary
Using ICP measurements and the bolus injection technique dynamic parameters of the cerebrospinal fluid system as there are pressure-volume-index (PVI) and resistance to CSF outflow (Rout) were investigated in a new model of diffuse closed head injury (CHI) in the rat. It was found that in the absence of brain oedema and ICP alterations an increase in PVI and Rout was present in the early (4 h) period following head injury. This may be indicative for a reduction in cerebral blood flow and cerebral blood volume, both shown previously to occur after CHI. Furthermore an early impairment of CSF absorption mechanisms is evident. To answer the question, whether bolus injection techniques are advisable for clinical routine and whether results might have a predictive value, further investigations covering longer observation intervals and in the presence of secondary insults to the brain are necessary.
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© 1998 Springer-Verlag Wien
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Schuhmann, M.U., Thomas, S., Hans, V.H.J., Beck, H., Brinker, T., Samii, M. (1998). CSF Dynamics in a Rodent Model of Closed Head Injury. In: Marmarou, A., et al. Intracranial Pressure and Neuromonitoring in Brain Injury. Acta Neurochirurgica Supplements, vol 71. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6475-4_87
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DOI: https://doi.org/10.1007/978-3-7091-6475-4_87
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-7331-2
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