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The molecular mechanism of dopamine-induced apoptosis: identification and characterization of genes that mediate dopamine toxicity

  • Conference paper
Advances in Research on Neurodegeneration

Summary

Parkinson’s disease (PD) is a progressive neurological disorder caused by rather selective degeneration of the dopaminergic (DA) neurons in the substantia nigra. Though subject to intensive research, the etiology of this nigral neuronal loss is still enigmatic and treatment is basically symptomatic. The current major hypothesis suggests that nigral neuronal death in PD is due to excessive oxidative stress generated by auto-and enzymatic oxidation of the endogenous neurotransmitter dopamine (DA), the formation of neuromelanin and presence of high concentrations of iron.

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Authors and Affiliations

  1. Department of Neurobiochemistry, George S, Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel

    A. Barzilai, R. Zilkha-Falb, D. Daily & N. Stern

  2. Department of Neurology and Felsenstein Medical Research Center, Rabin Medical Center, Beilinson Campus, Petach Tikva, Israel

    D. Offen, I. Ziv, E. Melamed & A. Shirvan

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  1. A. Barzilai
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  2. R. Zilkha-Falb
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  3. D. Daily
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  4. N. Stern
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  5. D. Offen
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  6. I. Ziv
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  7. E. Melamed
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  8. A. Shirvan
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Editor information

Editors and Affiliations

  1. Department of Psychiatry, University of WĂĽrzburg, Federal Republic of Germany

    P. Riederer

  2. Neurodegenerative Disorders Centre, Faculty of Medicine, University Hospital, Vancouver, B.C., Canada

    D. B. Calne

  3. Schering AG Berlin, Berlin, Federal Republic of Germany

    R. Horowski

  4. Department of Neurology, Juntendo University, Tokyo, Japan

    Y. Mizuno

  5. Department of Neurology, Mount Sinai Medical Center, New York, New York, USA

    C. W. Olanow

  6. Department of Neurology, University of Innsbruck, Innsbruck, Austria

    W. Poewe

  7. Department of Pharmacology, Faculty of Medicine, Technion, Haifa, Israel

    M. B. H. Youdim

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Barzilai, A. et al. (2000). The molecular mechanism of dopamine-induced apoptosis: identification and characterization of genes that mediate dopamine toxicity. In: Riederer, P., et al. Advances in Research on Neurodegeneration. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6301-6_4

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  • DOI: https://doi.org/10.1007/978-3-7091-6301-6_4

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