Zusammenfassung
Neuere Untersuchungen zeigen, dass Angststörungen die häufigsten psychiatrischen Erkrankungen überhaupt sind, so leiden ca. 15 bis 20% aller Patienten, die sich bei einem Allgemeinarzt vorstellen, an einer Angststörung. Bei der Pharmakotherapie dieser Störungen zeigt – ähnlich wie bei der Depression – ca. 1/3 der Patienten kein genügendes Ansprechen. Hier werden häufig Kombinationstherapien angewandt. Der vorliegende Beitrag fasst die hierzu vorliegenden Studien zusammen. Am besten ist die Hinzugabe eines atypischen Antipsychotikums (z. B. Risperidon) zu einer bestehenden SSRI-Therapie bei der Zwangsstörung gezeigt.
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Literatur
Aboujaoude E, Barry JJ, Gamel N (2009) Memantine augmentation in treatment-resistant obsessive-compulsive disorder: an open-label trial. J Clin Psychopharmacol 29: 51–55
Agid O, Lerer B (1999) Risperidone augmentation of paroxetine in a case of severe, treatment-refractory obsessive-compulsive disorder without comorbid psychopathology. J Clin Psychiaty 60: 55–56
Ahearn EP, Mussey M, Johnson C, Krohn A, Krahn D (2006) Quetiapine as an adjucntive treatment for post-traumatic stress disorder: an 8-week open-label study. Int Clin Psychopharmacol 21: 29–33
Ak M, Bulut SD, Bozkurt A, Ozsahin A (2011) Aripiprazol augmentation of serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder: a 10-week open-label study. Adv Ther 28: 341–348
Altamura AC, Serati M, Buoli M, Dell`Osso B (2011) Augmentative quetiapine in partial/nonresponders with generalized anxiety disorder: a randomized, placebo-controlled study. Int Clin Psychopharmacol 26: 201–205
D´Amico G, Cedro C, Muscatello MR, Pandolfo G, Di Rosa AE, Zoccali R, La Torre D, D`Arrigo C, Spina E (2003) Olanzapine augmentation of paroxetine-refractory obsessive-compulsive disorder. Prog Neuro-Psychopharmacol Biol Psychiatry 27: 619–623
Ashton AK (2005) Aripiprazole augmentation of combination escitalopram and sertraline in the treatment of refractory obsessive-compulsive disorder. Psychiatry 2: 18
Atmaca M, Kuloglu M, Tezcan E, Gecici O (2002) Quetiapine augmentation in patients with treatment resistant obsessive-compulsive disorder: a single-blind, placebo-controlled study. Int Clin Psychopharmacol 17: 115–119
Bandelow B, Rüther E (2004) Treatment-resistant panic disorder. CNS Spectrums 9: 725–739
Bartzokis G, Freeman T, Roca V, Kimbrell T, Brown SJ, Lu PH, Turner J, Mintz J, Saunders S (2003) Risperidone in the treatment of chronic combat-related posttraumatic stress disorder [Abstract]. Biol Psychiatry 53: 135S
Baxter LR, Li X, Jackson WT, May RS, Tolbert LC (2002) Adjunctive risperidone in the treatment of SSRI-refractory obsessive-compulsive disorder. Presented at the Society of Biological Psychiatry Annual Meeting, Philadelphia
Berlant JL (2004) Prospective open-label study of add-on and monotherapy topiramate in civilians with chronic nonhallucinatory posttraumatic stress disorder. BMC Psychiatry 18: 24
Berlin HA, Koran LM, Jenike MA, Shapira NA, Chaplin W, Pallanti S, Hollander E (2011) Double-blind, placebo-controlled trial of topiramate augmentation in treatment-resistant obsessive-compulsive disorder. J Clin Psychiatry 72: 716–721
Blier P (2001) Possible neurobiological mechanisms underlying faster onset of antidepressant action. J Clin Psychiatry 62 (Suppl 4): 7–11
Blier P, Bergeron R (1996) Sequential administration of augmentation strategies in treatment-resistant obsessive-compulsive disorder: preliminary findings. Int Clin Psychopharmacol 11: 37–44
Bloch MH, Landeros-Weisenberger A, Kelmendi B, Coric C, Bracken MB, Leckmann JF (2006) A systematic review: antipsychotic augmentation with treatment refractory obsessive-compulsive disorder. Mol Psychiatry 11: 622–632
Bogan AM, Koran LM, Chuong HW, Vapnik T, Bystritsky A (2005) Quetiapine augmentation in obsessive-compulsive disorder resistant to serotonin reuptake inhibitors: an open-label study. J Clin Psychiatry 66: 73–79
Bogetto F, Bellino S, Vaschetto P, Ziero S (2000) Olanzapine augmentation of fluvoxamine-refractory obsessive-compulsive disorder (OCD): a 12-week open trial. Psychiatry Res 96: 91–98
Brawman-Mintzer O, Knapp R, Nietert P (2005) Adjunctive risperidone in generzalized anxiety disorder: a double-blind, placebo-controlled study. J Clin Psychiatry 66: 1321–1325
Bruno A, Micó U, Padndolfo G, Mallamace D, Abenavoli E, Di Nardo F, D`Arrigo C, Spina E, Zoccali RA, Muscatello MR (2012) Lamotrigine augmentation of serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder: a double-blind, placebo-controlled study. J Psychopharmacol 26: 1456–1463
Buchsbaum MS, Hollander E, Pallanti S, Baldini Rossi N, Platholi J, Newmark R, Bloom R, Sood E (2006) Positron emission tomography imaging of risperidone augmentation in serotonin reuptake inhibitor-refractory patients. Neuropsychobiology 53: 157–168
Bystritsky A, Ackerman DL, Rosen RM, Vapnik T, Gorbis E, Maidmant KM, Saxena S (2004) Augmentation of serotonin reuptake inhibitors in refractory obsessive-compulsive disorder using adjunctive olanzapine: a placebo-controlled trial. J Clin Psychiatry 65: 565–568
Carey PD, Vythilingum B, Seedat S, Muller JE, van Ameringen M, Stein DJ (2005) Quetiapine augmentation of SRIs in treatment refractory obsessive-compulsive disorder: a double-blind, randomised, placebo-controlled study (ISRCTN83050762]. BMC Psychiatry 5: 5
Carey PD, Lochner C, Kidd M, Van Ameringen M, Stein DJ, Denys D (2012) Quetiapine augmentation of serotonin reuptake inhibitors in treatment-refractory obsessive-compulsive disorder: is response to treatment predictable? Int Clin Psychopharmacol 27: 321–325
Chao IL (2004) Olanzapine augmentation in panic disorder [Letter]. Pharmacopsychiatry 37: 239–240
Cohen LS (2003) Quetiapine in treatment resistant obsessive-compulsive disorder [letter]. J Am Acad Child Adolesc Psychiatry 42: 623–624
Cora-Locatelli G, Greenberg BD, Martin J, Murphy D (1998) Gabapentin augmentation for fluoxetine-treated patients with obsessive-compulsive disorder [letter]. J Clin Psychiatry 59 (Suppl 9): 480–481
Crane DL (2005) Ziprasidone as an augmenting agent in the treatment of anxiety-spectrum disorders. CNS Spectr 10: 176–179
Crockett BA, Churchilli E, Davidson JRT (2004) A double-blind combination study of clonazepam with sertraline in obsessive-compulsive disorder. Ann Clin Psychiatry 16: 127–132
Dannon PN, Iancu I, Grunhaus LJ (1999) Short-term potentiation of paroxetine with clonazepam in the treatment of patients with panic disorder [abstract, pp 153]. APA, Washington, D.C.
Dannon PN, Sasson Y, Hirschmann S, Iancu I, Grunhaus LJ, Zohar J (2000) Pindolol augmentation in treatment-resistant obsessive-compulsive disorder: a double-blind placebo controlled trial. Eur Neuropsychopharmacol 10: 165–169
da Rocca FF, Correa H (2007) Successful augmentation with aripiprazole in clomipramine-refractory obsessive-compulsive disorder. Progr Neuro-Psychopharmacol Biol Psychiatry 31: 1550–1551
David D, DeFaria L, Mellan TA (2006) Adjunctive risperidone treatment in combat veterans with chronic PTSD. Depress Anx 23: 489–491
Delgado PL, Goodman WK, Price LH, Heninger GR, Charney DS (1990) Fluvoxamine/pimozide treatment of concurrent Tourette`s and obsessive-compulsive disorder. Br J Psychiatry 157: 762–765
Dell`Osso B, Mundo E, Altamura AC (2006) Quetiapine augmentation of selective serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder: a six-month follow-up case series. CNS Spectr 11: 879–883
Denys D, van Megen H, Westenberg H (2002) Quetiapine addition to serotonin reuptake inhibitor treatment in pateints with treatment-refractory obsessive-compulsive disorder. An open-label study. J Clin Psychiatry 63: 700–703
Denys D, de Gues F, van Mengen HJGM, Westenberg HGM (2004) A double-blind, randomized, placebo-controlled trial of quetiapine addition in patients with obsessive-compulsive disorder refractory to serotonin reuptake inhibitors. J Clin Psychiatry 65: 1040–1048
Denys D, Fineberg N, Carey PD, Stein DJ (2007) Quetiapine addition in obsessive-compulsive disorder: is treatment outcome affected by type and dose of serotonin reuptake inhibitors. Biol Psychiatry 61: 412–414
Di Nicola M, Tedeschi D, Martinotti G, De Vita O, Monetta M, Pozzi G, Janiri L (2011) Pregabalin augmentation in treatment-resistant obsessive-compulsive disorder: a 16-week case series. J Clin Psychopharmacol 31: 675–677
Diniz JB, Shavitt RG, Fossaluza V, Koran L, Pereira CA, Miguel EC (2011) A double-blind, randomized, controlled trial of fluoxetine plus quetiapine or clomipramine versus fluoxetine plus placebo for obsessive-compulsive disorder. J Clin Psychopharmacol 31: 763–768
Dold M, Aigner M, Lanzenberger R, Kasper S (2011) Effektivität einer Augmentationstherapie mit Antipsychotika bei therapie-resistenten Zwangsstörungen – eine Metaanalyse doppelblinder, randomisierter, placebokontrollierter Studien. Fortschr Neurol Psychiatr 79: 453–466
Eppel AB (1989) Imipramine and clonazepam for panic disorder. Am J Psychiatry 146: 283
Erzegovesi S, Gulielmo E, Siliprandi F, Bellodi L (2005) Low-dose risperidone augmentation of fluvoxamine treatment in obesessive-compulsive disorder: a double-blind, placebo-controlled study. Eur Neuropsychopharmacol 15: 69–74
Etxebeste M, Aragüés E, Malo P, Pacheco L (2000) Olanzapine and panic attacks. Am J Psychiatry 157: 659–660
Figuero Y, Rosenberg DR, Birmaher B, Keshavan MS (1998) Combination treatment with clomipramine and selective serotonin reuptake inhibitors for obsessive-compulsive disorder in children and adolescents. J Child Adolesc Psychopharmacol 8: 61–67
Filteau MJ, Leblanc J, Bouchard RH (2003) Quetiapine reduces flashbacks in chronic posttraumatic stress disorder [letter]. Can J Psychiatry 48: 282–283
Fineberg NA, Sivakumaran T, Roberts A, Gale T (2005) Adding quetiapine to SRI in treatment-resistant obsessive-compulsive disorder: a randomized controlled treatment study. Int Clin Psychopharmacol 20: 223–226
Fineberg NA, Gale TM, Sivakumaran T (2006a) A review of antipsychotics in the treatment of obsessive compulsive disorder. J Psychopharmacol 20: 97–103
Fineberg NA, Stein DJ, Premkumar P, Carey P, Sivakumaran T, Vythilingum B, Seedat S, Westenberg H, Denys D (2006b) Adjunctive quetiapine for serotonin reuptake inhibitor-resistant obsessive-compulsive disorder: a meta-analysis of randomized controlled treatment trials. Int Clin Psychopharmacol 21: 337–343
Fitzgerald KD, Stewart CM, Tawille V, Rosenberg DR (1999) Risperidone augmentation of serotonin reuptake inhibitor treatment of pediatric obsessive compulsive disorder. J Child Adolesc Psychopharmacol 9: 115–123
Fontenelle LF, Mendlowicz MV, Miguel EC, Versiani M (2005) Citalopram plus reboxetine in treatment-resistant obsessive-compulsive disorder. Word J Biol Psychiatry 6: 57–59
Francobandiera G (2001) Olanzapine augmentation of serotonin reuptake inhibitors in obsessive-compulsive disorder: an open study. Can J Psychiatry 46: 356–358
Friedman S, Abdallah TA, Oumaya M, Rouillon F, Guelfi JD (2007) Aripiprazole augmentation of clomipramine-refractory obsessive-compulsive disorder [letter]. J Clin Psychiatry 68: 972–973
Fux M, Benjamin J, Belmaker RH (1999) Inositol versus placebo augmentation of serotonin reuptake inhibitors in the treatment of obsessive-compulsive disorder: A double-blind cross-over study. In J Neuropsychopharmacol 2: 193–195
Gabriel A (2011) The extended-release formulation of quetiapine fumarate (quetiapine XR) adjunctive treatment in partially responsive generalized anxiety disorder (GAD): An open label naturalistic study. Clin Ther 162: 113–118
Gastfriend D, Rosenbaum J (1989) Adjunctive buspirone in benzodiazepine treatment of four patients with panic disorder. Am J Psychiatry 146: 914–916
Goddard AW, Brouette T, Almai A, Jetty P, Ciary C, Woods S, Charney D (2001) Early co-administration of clonazepam with sertralin: a safe, rapidly acting treatment for panic disorder. Arch Gen Psychiatry 58: 681–686
Goldstein S (1986) Sequential treatment of panic disorder with alprazolam and imipramine. Am J Psychiatry 143: 1634
Grady T, Pigott TA, L´Heureux F, Hill J, Bernstein L, Murphy D (1993) A double-blind study of adjuvant buspirone hydrochloride in fluoxetine-treated patients with OCD. Am J Psychiatry 150: 819–821
Hamner MB, Deitsch SE, Brodrick PS, Ulmer HG, Lorberbaum JP (2002) Quetiapine treatment in patients with posttraumatic stress disorder: an open trial of adjunctive therapy. J Clin Psychopharmacol 23: 15–20
Hamner MB, Faldowski RA, Ulmer HG, Frueh BC, Huber MG, Arana GW (2003) Adjunctive risperidone treatment in post-traumatic stress disorder: a preliminary controlled trial of effects on comorbid psychotic symptoms. Int Clin Psychopharmacol 18: 1–8
Harada T, Yamada K, Sakamoto K, Ishigooka J (2009) Aripiprazole augmentation for a patient with partial remission of panic disorder. J Clin Psychopharmacol 29: 301–302
Heresco-Levy U, Vass A, Bloch, Wolosker H, Dumin E, Balan L, Deutsch L, Kremer I (2009) Pilot controlled trial of D-serine for the treatment of post-traumatic stress disorder. Int J Neuropsychopharmacol 12: 1275–1282
Higuma H, Kanehisa M, Maruyama Y, Ishitobi Y, Tanaka Y, Tsuru J, Hanada H, Kodama K, Isogawa K, Akiyoshi J (2012) Aripiprazole augmentation in 13 patients with refractory obsessive-compulsive disorder: a case series. World J Biol Psychiatry 13: 14–21
Hirschmann S, Dannon PN, Iancu I, Dolberg OT, Zohar J, Grunhaus L (2000) Pindolol augmentation in patients with treatment-resistant panic disorder: A double-blind, placebo-controlled trial. J Clin Psychopharmacol 20: 556–559
Hollander E, Baldini Ross N, Sood E, Pallanti S (2003) Risperidone augmentation in treatment-resistant obsessive-compulsive disorder: a double-blind, placebo-controlled study. Int J Neuropsychopharmacol 6: 397–401
Hollander E, Dell`Osso B (2006) Topiramate plus paroxetine in treatment-resistant obsessive-compulsive disorder. Int Clin Psychopharmacol 21: 189–191
Ipser JC, Carey P, Dhansay Y, Fakier N, Seedat S, Stein DJ (2006) Pharmacotherapy augmentation strategies in treatment-resistant anxiety disorders. Cochrane Database Syst Rev Oct 18; (4): CD005473
Iwata Y, Kotani Y, Hoshino R, Takei N, Iyo M, Mori N (2000) Carbamazepine augmentation of clomipramine in the treatment of refractory obsessive-compulsive disorder [letter]. J Clin Psychiatry 61: 528–529
Jakovljević M, Šagud M, Mihaljević-Peleš A (2003) Olanzapine in the treatment-resistant combat-related PTSD – a series of case reports. Acta Psychiatr Sand 107: 394–396
Jenike MA, Baer L, Buttolph L (1991) Buspirone augmentation of fluoxetine in patients with obsessive compulsive disorder. J Clin Psychiatry 1: 13–14
Karaiskos D, Pappa D, Tzavellas E, Siarkos K, Katirtzoglou E, Papadimitriou GN, Politis A (2013) Pregabalin augmentation of antidepressants in older patients with comorbid depression and generalized anxiety disorder – an open-label study. Int J Geriatr Psychiatry 28: 100–105
Kasper S (2007) Neurotische, Belastungs- und somatoforme Störungen. In: Kasper S, Volz HP (Hrsg): Psychiatrie compact, Thieme, Stuttgart, S. 141–179
Kazzelnick DJ, Saidi J, Vanelli MR, Jefferson JW, Harper JM, McCrary KE (2006) Time to response in panic disorder in a naturalistic setting: Combination therapy with alprazolam orally disintegrating tablets and serotonin reuptake inhibitors compared to serotonin reuptake inhibitors alone. Psychiatry 3: 39–49
Katzman MA, Vermani M, Jacobs L, Marcus M, Kong B, Lessard S, Galarraga W, Struzik L, Gendron A (2008) Quetiapine as an adjunctive pharmacotherapy for the treatment of non-remitting generalized anxiety disorder: a flexible-dose, open-label pilot trial. J Anxiety Disord 22: 1480–1486
Keck PE Jr, McElroy SL, Tugrul KC, Bennett JA, Smith HM (1993) Antiepileptic drugs for the treatment of panic disorder. Neuropsychobiology 27: 150–153
Khaldi S, Kornreich C, Dan B, Pelc I (2003) Usefulness of olanzapine in refractory panic patients. J Clin Psychopharmacol 23: 100–101
Koran LM, Ringold AL, Elliot MA (2000) Olanzapine augmentation for treatment-resistant obsessive-compulsive disorder. J Clin Psychiatry 61 (Suppl 7): 514–517
Koran LM, Aboujaoude E, Gamel NN (2009) Double-blind study of dextroamphetamine versus caffeine augmentation for treatment-resistant obsessive-compulsive disorder. J Clin Psychiatry 70: 1530–1535
Kordon A, Wahl K, Koch N, Zurowski B, Anlauf M, Vielhaber K, Kahl KG, Broocks A, Voderholzer U, Hohagen F (2008) Quetiapine addition to serotonin reuptake inhibitors in patients with severe obsessive-compulsive disorder: a double-blind, randomized, placebo-controlled study. J Clin Psychopharmacol 28: 550–554
Leonard HL, Topol D, Burkstein O, Hindmarsh D, Allen AJ, Swedo SE (1994) Clonazepam as an augmenting agent in the treatment of childhood-onset obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry 33: 792–794
Li X, May RS, Tolbert LC, Jackson WT, Flournoy JM, Baxter LR (2005) Risperidone and haloperidol augmentation of serotonin reuptake inhibitors in refractory obsessive-compulsive disorder: a cross-over study. J Clin Psychiatry 66: 736–743
Lykouras L, Alevizos B, Michalopoulou P, Rabavilas A (2003) Obsessive-compulsive symptoms induced by atypical antipsychotics. A review of reported cases. Progr Neuro-Psychopharmacol Biol Psychiatry 27: 333–346
Mahboub N, Asemota B, Alexopoulos GS (2011) The effect of riluzole augmentation in a patient with treatment-resistant obsessive-compulsive disorder, taking two other glutamatergic agents. J Neuropsychiatry Clin Neurosci 23: E24–E25
Maina G, Albert U, Ziero S, Bogetto F (2003) Antipsychotic augmentation for treatment resistant obsessive-compulsive disorder: what if antipsychotic is discontinued? Int Clin Psychopharmacol 18: 23–28
Mancini C, van Ameringen M, Farvolden P (2002) Does SSRI augmentation with antidepressants that influence noradrenergic function resolve depression in obsessive-compulsive disorder? J Affect Dis 68: 59–65
Marazitti D, Pallanti S (1999) Effectiveness of olanzapine treatment for severe obsessive-compulsive disorder. Am J Psychiatry 156: 1834–1835
Marazziti D, Pfanner C, Dell`Osso B, Ciapparelli A, Presta S, Corretti G, Di Nasso E, Mungai F, Dell`Osso L (2005) Augmentation strategy with olanzapine in resistant obsessive compulsive disorder: an Italian ling-term open-label study. J Psychopharmacol 19: 392–394
Markovitz PJ, Stagno SJ, Calabrese JR (1990) Buspirone augmentation of fluoxetine in obsessive-compulsive disorder. Am J Psychiatry 147: 798–800
Masi G, Pfanner C, Millepiedi S, Berloffa S (2010) Aripirprazole augmentation in 39 adolescents with medication-resistant obsessive-compulsive disorder. J Clin Psychopharmacol 30: 688–693
Masdrakis VG, Papadimitriou GN, Oulis P (2010) Lamotrigine administration in panic disorder with agoraphobia. Clin Neuropharmacol 33: 126–128
Matsunaga H, Hayashida K, Maebayashi K, Mito H, Kiriike N (2011) A case series of aripiprazole augmentation of selective serotonin reuptake inhibitors in treatment-refractory obsessive-compulsive disorder. Int J Psychiatry Clin Pract 15: 263–269
Mattes JA (1986) A pilot study of combined trazodone and tryptophan in obsessive-compulsive disorder. Int Clin Psychopharmacol 1: 170–173
McDougle CJ, Goodman WK, Price LH, Delgado PL, Krystal JH, Charney DS, Heninger GR (1990) Neuroleptic addition in fluvoxamine-refractory obsessive-compulsive disorder. Am J Psychiatry 147: 652–654
McDougle C, Price L, Goodman W, Charney D, Heninger G (1991) A controlled trial of lithium augmentation in fluvoxamine-refractory obsessive-compulsive disorder. J Clin Psychopharmacol 11: 175–184
McDougle CJ, Goodman WK, Leckman JF, Lee NC, Heninger GR, Price LH (1994) Haloperidol addition in fluvoxamine-refractory obsessive-compulsive disorder. A double-blind, placebo-controlled study in patients with and without tics. Arch Gen Psychiatry 51: 302–308
McDougle CJ, Fleischmann RL, Epperson CN, Wasylink S, Leckman JF, Price LH (1995) Risperidone addition in fluvoxamine-refractory obsessive-compulsive disorder: three cases. J Clin Psychiatry 56: 527–528
McDougle CJ, Eppersen CN, Pelton GH, Wasylink S, Price LH (2000) A double-blind, placebo-controlled study of risperidone addition in serotonin reuptake inhibitory-refractory obsessive-compulsive disorder. Arch Gen Psychiatry 57: 794–801
Menza MA, Dobkin RD, Marin H (2007) An open-label trial of aripiprazol for treatment-resistant generalized anxiety disorder. J Clin Psychopharmacol 27: 207–210
Misri S, Milis L (2004) Obsessive-compulsive disorder in the postpartum. Open-label trial of quetiapine augmentation. J Clin Psychopharmacol 24: 624–627
Mohr N, Vythilingum B, Ernsley RA, Stein DJ (2002) Quetiapine augmentation of serotonin reuptake inhibitors in obsessive-compulsive disorder. Int Clin Psychopharmacol 17: 37–40
Monnelly E, Ciraulo DA, Knapp C, Keane TM (2003) Low dose risperidone as adjunctive therapy for irritable aggression in posttraumatic stress disorder. J Clin Psychopharmacol 23: 193–196
Mundo E, Guglielmo E, Bellodi L (1998) Effect of adjuvant pindolol on the antiobsessional response to fluvoxamine: a double-blind, placebo-controlled study. Int J Psychopharmacol 13: 219–224
Muscatello MR, Bruno A, Pandolfo G, Micò U, Scimeca G, Romeo VM, Santoro V, Settineri S, Spina E, Zoccali RA (2011) Effect of aripiprazole augmentation of serotonin reuptake inhibitors or clomipramine in treatment-resistant obsessive-compulsive disorder: a double-blind, placebo-controlled study. J Clin Psychopharmacol 31: 174–179
Noorbala AA, Hosseini SH, Mohammadi MR, Akhondzadeh S (1998) Combination of clomipramine and nortriptyline in the treatment of obsessive-compulsive disorder: a double-blind, placebo-controlled trial. J Clin Pharm Ther 23: 155–159
Ontiveros A, Fontaine R (1992) Sodium valproate and clonazepam for treatment-resistant panic disorder. J Psychiatry Neurosci 17: 78–80
Oshimo T, Ohta M, Ueno R, Hashimoto T, Shirakawa O, Maeda K (2003) Effects of combined use of serotonin reuptake inhibitor and risperidone for obsessive-compulsive disorders [abstract]. Int Clin Psychopharmacol 18: 185
Oulis P, Masdrakis VG, Karapoulios E, Krakatsanis NA, Kouzoupis AV, Kontantakopoulos G, Soldatos CR (2008) Pregabalin augmentation to sertraline-risperidone combination in the treatment of obsessive-compulsive disorder. Prim Care Companion J Clin Psychiatry 10: 249
Oulis P, Masdrakis VG, Karapoulios E, Karakatsanis NA, Kouzoupis AV, Konstantakopoulos G, Soldatos CR (2009) Tiagebine augmentation to fluvoxamine-risperidone combination in the treatment of obsessive-compulsive disorder. World J Biol Psychiatry 10: 953–955
Oulis P, Mourikis I, Konstantakopoulos G (2011) Pregabalin augmentation in treatment-resistant obsessive-compulsive disorder. Int Clin Psychopharmacol 26: 221–224
Pae CU, Marks DM, Han C, Masand PS, Patkar AA (2009) Pregabalin augmentation of antidepressants in patients with accident-related posttraumatic stress disorder: an open label pilot study. Int Clin Psychopharmacol 24: 29–33
Pallanti S, Quercioli L, Paiva RS, Koran LM (1999) Citalopram for treatment-resistant obsessive-compulsive disorder. Eur Psychiatry 14: 101–106
Pallanti S, Quercioli L, Bruscoli M (2004) Response acceleration with mirtazapine augmentation of citalopram in obsessive-compulsive disorder patients without comorbid depression: A pilot study. J Clin Psychiatry 65: 1394–1399
Pallanti S, Bernardi S, Antonini S, Singh N, Hollander E (2009) Ondansetron augmentation in treatment-resistant obsessive-compulsive disorder: a preliminary, single-blind, prospective study. CNS Drugs 23: 1047–1055
Pasquini M, Biondi M (2006) Memantine augmentation for refractory obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry 30: 1173–1175
Pasquini M, Berardelli I, Biondi M (2010) Amantadine augmentation for refractory obsessive-compulsive disorder: a case report. J Clin Psychpharmacol 30: 85–86
Pessina E, Albert U, Bogetto F, Maina G (2009) Aripiprazol augmentation of serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder: a 12-week open-label preliminary study. Int Clin Psychopharmacol 24: 265–269
Pfanner C, Marazziti D, Dell`Osso L, Presta S, Gemignani A, Milanfranchi A, Cassano GB (2000) Risperidone augmentation in refractory obsessive-compulsive disorder: an open-label study. Int Clin Psychopharmacol 15: 297–301
Pigott TA, L`Heureux F, Hill JL, Bihari K, Bernstein SE, Murphy DL (1992) A double-blind study of adjuvant buspirone hydrochloride in clomipramine-treated patients with obsessive-compulsive disorder. J Clin Psychopharmacol 12: 11–18
Pitchot W, Ansseau M (2012) Efficacy of quetiapine in treatment-resistant panic disorder: a case report. Asian J Psychiatr 5: 204–205
Pittenger C, Kelmendi B, Wasylink S, Bloch MH, Coric V (2008) Riluzole augmentation in treatment-refractory obsessive-compulsive disorder: a series of 13 cases, with long-term follow-up. J Clin Psychopharmacol 28: 363–367
Pollack MH, Simon NM, Worthington JJ, Doyle AL, Peters P, Toshkov F, Otto MW (2003) Combined paroxetine and clonazepam treatment strategies compared to paroxetine monotherapy for panic disorder. J Psychopharmacol 17: 276–282
Pollack MH, Simon NM, Zalta AK, Worthington JJ, Hoge EA, Mick E, Kinrys G, Oppenheimer J (2006) Olanzapine augmentation of fluoxetine for refractory generalized anxiety disorder: a placebo-controlled study. Biol Psychiatry 59: 211–215
Pollack M, Kinrys G, Krystal A, McCall WV, Roth T, Schaefer K, Rubens R, Roach J, Huang H, Krishnan R (2008). Eszopiclone coadministered with escitalopram in patients with insomnia and comorbid generalized anxiety disorder. Arch Gen Psychiatry 65: 551–562
Poyurovsky M, Weizman R, Weizman A, Koran L (2005) Memantine for treatment-resistant OCD [letter]. Am J Psychiatry 162: 2191–2192
Presecki P, Mihanović M, Silić A, Vuina AL, Caratan S (2010) Venlafaxine-quetiapine combination in the treatment of complicated clinical picture of enduring personality changes following PTSD in comorbidity with psychotic depression. Psychiatr Danub 22: 360–362
Rapaport MH, Skarky SB, Katzelnick DJ, DeWester JN, Harper JM, McCrary KE (2006) Time to response in generalized anxiety disorder in a naturalistic setting: Combination therapy with alprazolam orally disintegrating tablets and serotonin reuptake inhibitors compared to serotonin reuptake inhibitors alone. Psychiatry 3: 50–59
Rasmussen S (1984) Lithium and tryptophan augmentation in clomipramine-resistant OCD. Am J Psychiatry 141: 1283–1285
Ravizza L, Barzega G, Bellino S, Bogetto F, Maina G (1996) Therapeutic effect and safety of adjunctive risperidone in refractory obsessive-compulsive disorder (OCD). Psychopharmacol Bull 32: 677–682
Richardson JD, Fikretoglu D, Liu A, McIntosh D (2011) Aripiprazole augmentation in the treatment of military-related PTSD with major depression: a retrospective chart review. BMC Psychiatry 11: 86
Rickels K, Shiovitz TM, Ramey TS, Weaver JJ, Knapp LE, Miceli JJ (2012) Adjunctive therapy with pregabalin in generalized anxiety disorder patients with partial response to SSRI or SNRI therapy. Int Clin Psychopharmacol 27: 142–150
Riddle MA, Leckman JF, Hardin MT, Anderson GM, Cohen DJ (1988) Fluoxetine treatment of obsessions and compulsions in patients with Tourette`s syndrome [letter]. Am J Psychiatry 145: 1173–1174
Rodiguez CI, Bender J Jr, Marcus SM, Snape M, Rynn M, Simpson HB (2010) Monocycline augmentation of pharmacotherapy in obsessive-compulsive disorder: an open-label trial. J Clin Psychiatry 71: 1247–1249
Rubio G, Jiménez-Arriero MA, Martínez-Gras I, Manzanares J, Palomo T (2006) The effects of topiramate adjunctive treatment added to antidepressants in patients with resistant obsessive-compulsive disorder. J Ciin Psychopharmacol 26: 341–334
Saito M, Miyaoka H (2007) Augmentation of paroxetine with clocapramine in panic disorder [letter]. Psychiatry Clin Neurosci 61: 449
Sareen J, Kirshner A, Lander M, Kjernisted KD, Eleff MK, Reiss JP (2004) Do antipsychotics ameliorate or exacerbate Obsessive-Compulsive Disorder symptoms? A systematic review. J Affect Disord 82: 167–174
Sarkar R, Klein J, Krüger S (2008) Aripiprazole augmentation in treatment-refractory obsessive-compulsive disorder. Psychopharmacology 197: 687–688
Sattar SP, Ucci B, Grant K, Bhatia SC, Petty F (2002) Quetiapine therapy for posttraumatic stress disorder. Ann Pharmacother 36: 1875–1878
Saxena S, Wang D, Bystritsky A, Baxter LR (1996) Risperidone augmentation of SRI treatment for refractory obsessive-compulsive disorder. J Clin Psychiatry 57: 303–306
Sayyah M, Boostani H, Pakseresht S, Malayeri A (2011) A preliminary randomized double-blind clinical trial on the efficacy of celecoxib as an adjunct in the treatment of obsessive-compulsive disorder. Psychiatry Res 189: 403–406
Sayyah M, Olapour A, Saeedabad Ys, Yazdan Parast R, Malayeri A (2012a) Evaluation of oral zinc sulfate on obsessive-compulsive disorder: a randomized placebo-controlled trial. Nutrition 28: 892–895
Sayyah M, Saayah M, Boostani HI, Ghaffari SM, Hoseini A (2012b) Effects of aripiprazole augmentation in treatment-resistant obsessive-compulsive disorder (a double blind clinical trial). Depress Anxiety 29: 850–854
Schutters SI, van Megen HJ, Van Veen JF, Schruers KR, Westenberg HG (2011) Paroxetine augmentation in patients with generalized social anxiety disorder, non-responsive to mirtazapine or placebo. Hum Psychopharmacol 26: 72–76
Seedat S, Stein MB (2004) Double-blind, placebo-controlled assessment of combined clonazepam with paroxetine compared with paroxetine monotherapy for generalized social anxiety disorder. J Clin Psychiatry 65: 244–248
Selvi Y, Atli A, Aydin A, Besiroglu L, Ozdemir P, Ozdemir O (2011) The comparison of aripiprazole and risperidone augmentation in selective serotonin reuptake inhibitor-refractory obsessive-compulsive disorder: a single-blind, randomised study. Hum Psychopharmacol 26: 51–57
Sepede G, De Beradis D, Gambi F, Campanella D, La Rovere R, D`Amico M, Cicconetti A, Penna L, Peca S, Carano A, Mancini E, Salerno RM, Ferro FM (2006) Olanzapine augmentation in treatment-resistant panic disorder: a 12-week, fixed-dose, open-label trial. J Clin Psychopharmacol 26: 45–49
Shad MU, Suris AM, North CS (2011) Novel combination strategy to optimize treatment for PTSD. Hum Psychopharmacol 26: 4–11
Shapira NA, Ward HE, Mandoki M, Murphy TK, Yang MCK, Blier P, Goodman WK (2004) A double-blind, placebo-controlled trial of olanzapine addition to fluoxetine-refractory obsessive-compulsive disorder. Biol Psychiatry 55: 553–555
Simon NM, Safren SA, Otto MW, Sharma SG, Lanka GD, Pollack MH (2002) Longitudinal outcome with pharmacotherapy in a naturalistic study of panic disorders. J Affect Dis 69: 33–34
Simon NM, Connor KM, LeBeau RT, Hoge EA, Worthington JJ 3rd, Zhang W, Davidson JR, Pollack MH (2008) Quetiapine augmentation of paroxetine CR for the treatment of refractory generalized anxiety disorder: preliminary findings. Psychopharmacology (Berl) 197: 675–681
Soltani F, Sayyah M, Feizy F, Malayeri A, Siahpoosh A, Motlagh I (2010) A double-blind, placebo-controlled pilot study of ondansetron for patients with obsessive-compulsive disorder. Hum Psychopharmacol 25: 509–513
States JH, St. Dennis CK (2003) Chronic sleep disruption and the reexperiencing cluster of posttraumatic stress disorder symptoms are improved by olanzapine: Brief review of the literature and a case-based series. J Clin Psychiatry 5: 74–79
Stein MB, Sareen J, Hami S, Chao J (2001) Pindolol potentiation of paroxetine for generalized social phobia: a double-blind, placebo-controlled, cross-over study. Am J Psychiatry 158; 1725–1727
Stein MB, Kline NA, Matloff JL (2002) Adjunctive olanzapine for SSRI-resistant combat-related PTSD: A double-blind, placebo-controlled study. Am J Psychiatry 159: 1777–1779
Storch EA, Lehmkuhl H, Geffken GR, Touchton A, Murphy TK (2008) Aripiprazole augmentation of incomplete treatment response in an adolescent male with obsessive-compulsive disorder. Depress Anx 25: 172–174
Tiffon L, Coplan JJD, Papp LA, Gorman JM (1994) Augmentation strategies with tricyclic or fluoxetine treatment in seven partially responsive panic disorder patients. J Clin Psychiatry 55: 66–69
Uhlenhuth EH, Balter MB, Ban TA, Yang K (1998) International study of expert judgement on therapeutic use of benzodiazepines and other psychotherapeutic medications: V. Treatment strategies in panic disorder, 1992–1997. J Clin Psychopharmacol 18 (Suppl 2): 27S–31S
Uzun O (2010) Lamotrigin as an augmentation agent in treatment-resistant obsessive-compulsive disorder: a case-report. J Psychopharmacol 24: 425–427
Van Ameringen M, Mancini C, Wilson C (1996) Buspirone augmentation of selective serotonin reuptake inhibitors (SSRIs) in social phobia. J Affect Disord 39: 115–121
Van Ameringen M, Mancini C, Patterson B, Bennett M (2006) Topiramate augmentation in treatment-resistant obsessive-compulsive disorder: a retrospective, open-label case series. Depress Anxiety 23: 1–5
Weiss EL, Potenza MN, McDougle CJ, Epperson CN (1999) Olanzapine addition in obsessive-compulsive disorder refractory to selective serotonin reuptake inhibitors: an open-label case series. J Clin Psychiatry 60: 524–527
Woods SW, Nagy LM, Koleszar AS, Krystal JH, Heninger GR, Charney DS (1992) Controlled trial of alprazolam supplementation during imipramine treatment of panic disorder. J Clin Psychopharmacol 12: 32–38
Yoshimura R, Kaneko S, Shinkai K, Nakamura J (2006) Successful treatment for obsessive-compulsive disorder with addition of low-dose risperidone to fluvoxamine: implications for plasma levels of catecholamine metabolites and serum brain-derived neurotrophic factor levels. Psychiatry Clin Neurosci 60: 389–393
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Volz, HP. (2016). Kombinationen mit Psychopharmaka in der Behandlung von Angst- und Zwangsstörungen. In: Messer, T., Schmauß, M. (eds) Polypharmazie in der Behandlung psychischer Erkrankungen. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1849-8_8
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