Skip to main content

Cryoglobulinemia

  • Chapter
  • First Online:
Skin Necrosis

Abstract

Cryoglobulinemia (CR) is a disease characterized by the presence, in the serum, of abnormal proteins that precipitate reversibly at low temperatures, and generally the cryoglobulins lead to a systemic inflammatory syndrome characterized by myalgia, arthralgia, purpura (Meltzer’s triad), neuropathy, and glomerulonephritis [1]. According to immunochemical characteristic, cryoglobulins have been classified into 3 distinct groups:

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 59.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 79.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Takada S, Shimizu T, Hadano Y, et al. Cryoglobulinemia (review). Mol Med Rep. 2012;6(1):3–8.

    CAS  PubMed  Google Scholar 

  2. Krishnaram AS, Geetha T, Pratheepa, Saigal A. Primary cryoglobulinemia with cutaneous features. Indian J Dermatol Venereol Leprol 2013;79:427–430.

    Google Scholar 

  3. Levo Y. Nature of cryoglobulinemia. Lancet. 1980;1:285–7.

    Article  CAS  PubMed  Google Scholar 

  4. Grey HM, Kohler PF. Cryoimmunoglobulins. Semin Hematol. 1973;10:87–112.

    CAS  PubMed  Google Scholar 

  5. Dammacco F, Sansonno D. Therapy for hepatitis C virus–related cryoglobulinemic vasculitis. N Engl J Med. 2013;369(11):1035–45.

    Article  CAS  PubMed  Google Scholar 

  6. De Vita S, Quartuccio L, Isola M, et al. A randomized controlled trial of Rituximab for the treatments of severe cryoglobulinemic vasculitis. Arthritis Rheum. 2012;64(3):843–53.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Marco Romanelli MD, PhD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer-Verlag Wien

About this chapter

Cite this chapter

Panduri, S., Dini, V., Romanelli, M. (2015). Cryoglobulinemia. In: Téot, L., Meaume, S., Akita, S., Ennis, W.J., del Marmol, V. (eds) Skin Necrosis. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1241-0_28

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-1241-0_28

  • Published:

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-1240-3

  • Online ISBN: 978-3-7091-1241-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics