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Surfactant Protein-D

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Animal Lectins: Form, Function and Clinical Applications

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Abstract

The collectins can be classed into two distinct group, with MBP and SP-A being hexamers and SP-D, conglutinin and collectin-43 (CL-43) being tetramers, with proteins in the latter group also having significantly larger dimensions with respect to the length of their collagen-like ‘stalks’ (Lu et al. 1993). MBP, lung SP-D, conglutinin, CL-43 and CL-46 are important components of innate immune defence system. They all bind complex glycoconjugates on microorganisms thereby inhibiting infection, enhancing the clearance by phagocytes and modulating the immune response. In addition, SP-D inhibits the generation of radical oxygen species or the propagation of lipid peroxidation. Knock-out mice deficient in SP-D have a disturbed homeostasis of pulmonary surfactant and suffer from oxidative stress leading to pulmonary inflammation upon microbial challenge. Moreover, both SP-D and SP-A (Chap. 24) have been shown to enhance oxygen radical production by alveolar macrophages. The structural and functional relationships of this group of collectins have been reviewd (Hansen and Holmskov 2002; Jinhua et al. 2003).

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  1. Vaccine Production Division, Panacea Biotec, Lalru (Mohali), Punjab, India

    Rajesh K. Gupta (General Manager)

  2. Department of Biomedical Engineering, Rayat and Bahra Institute of Engineering and Biotechnology, Kharar (Mohali), Punjab, India

    Anita Gupta (Assistant Professor)

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Gupta, R.K., Gupta, A. (2012). Surfactant Protein-D. In: Animal Lectins: Form, Function and Clinical Applications. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1065-2_25

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