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New Aspects of the Contribution of ER to SOCE Regulation

The Contribution of SERCA to the Regulation of SOCE

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Store-operated Ca2+ entry (SOCE) pathways

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Abstract

Apart from amplifying the cytosolic Ca2+ signals generated by Ca2+ mobilization from the endoplasmic reticulum (ER), capacitative calcium entry (CCE) is essential for quick refilling of the ER, which is necessary for repeating Ca2+ signals. SERCA is the third element of CCE. It co-localizes with STIM1 and Orai1 at puncta where it is tightly coupled to plasma membrane store-operated Ca2+ channels (SOC). This allows an extremely efficient refilling of the ER stores with the Ca2+ entering through activated SOC. Whereas ER takes up most of the store-operated Ca2+ entry, mitochondria takes up a very little part. Low mitochondrial Ca2+ uptake can be explained by longer distance to SOC and lower Ca2+ affinity of mitochondrial uptake mechanisms.

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Authors and Affiliations

  1. Instituto de Biología y Genética Molecular (IBGM), Universidad de Valladolid y Consejo Superior de Investigaciones Científicas (CSIC), Valladolid, Spain

    Javier García-Sancho & María Teresa Alonso

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  1. Javier García-Sancho
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  2. María Teresa Alonso
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Correspondence to Javier García-Sancho .

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Editors and Affiliations

  1. Center for Physiological Medicine, Medical University of Graz, Harrachgasse 21/IV, Graz, 8010, Austria

    Klaus Groschner

  2. , Center for Molecular Medicine, Medical University of Graz, Harrachgasse 21/III, Graz, 8010, Austria

    Wolfgang F. Graier

  3. , Institute of Biophysics, University of Linz, Gruberstrasse 40, Linz, 4020, Austria

    Christoph Romanin

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García-Sancho, J., Alonso, M.T. (2012). New Aspects of the Contribution of ER to SOCE Regulation. In: Groschner, K., Graier, W., Romanin, C. (eds) Store-operated Ca2+ entry (SOCE) pathways. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0962-5_11

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