Skip to main content
SpringerLink
Log in

Mitogen-activated protein kinases phosphorylation in posttraumatic selective vulnerability in rats

  • Conference paper
Brain Edema XII

Part of the book series: Acta Neurochirurgica Supplements ((NEUROCHIRURGICA,volume 86))

Abstract

Mitogenic stimulation of the Mitogen-activated protein kinase (MAPK) pathway modulates the activity of many transcriptional factors leading to biological responses. Of these, three MAPK cascades are well characterized as extracellular signal-regulated protein kinase (ERK), c-Jun NH(2)-terminal kinase (JNK), and p38 pathways. The aim of this study was to investigate the topographic distribution and the role of activated MAPK pathways after fluid percussion injury (FPI) in rats. In the present results, FPI significantly induced ERK- and JNK-phosphorylation, but not p38-phosphorylation in the cortex and hippocampus at the injury site. The immunoreactivity for phospho-ERK was localized in the superficial neuronal layers, dentate hilar neurons, and the damaged CA3 neurons after 30 mins of FPI. Double immunostaining showed that phospho-ERK was prominent in astrocytes 6 hrs after TBI. The current results suggest that MAPK pathways are involved in signal transduction after FPI.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Cortez SC, Mcintosh TK, Noble LJ (1989) Exerimental fluid percussion brain injury: vascular disruption and neuronal and glial alterations. Brain Res 482: 271–282

    Article  PubMed  CAS  Google Scholar 

  2. Lowenstein DH, Thomas MJ, Smith DH et al (1992) Selective vulnerability of dentate hilar neurons following traumatic brain injury: a potential mechanistic link between head trauma and disorders of the hippocampus. J Neurosci 12: 4846–4853

    PubMed  CAS  Google Scholar 

  3. Matsushita Y, Shima K, Nawashiro H et al (2000) Real-time monitoring of glutamate following fluid percussion brain injury with hypoxia in the rat. J Neurotrauma 17: 143–153

    Article  PubMed  CAS  Google Scholar 

  4. Scheff SW, Baldwin SA, Brown RW (1997) Morris water maze deficits in rats following traumatic brain injury: lateral controlled cortical impact. J Neurotrauma 14: 615–627

    Article  PubMed  CAS  Google Scholar 

  5. Sugino T, Nozaki K, Takagi Y et al (2000) Activation of mitogen-activated protein kinases after transient forebrain ischemia in gerbil hippocampus. J Neurosci 20: 4506–4515

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurosurgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan

    Naoki Otani M.D., H. Nawashiro, N. Tsuzuki, H. Katoh, T. Miyazawa & K. Shima

Authors
  1. Naoki Otani M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Nawashiro
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. Tsuzuki
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. Katoh
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. T. Miyazawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. K. Shima
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

    T. Kuroiwa

  2. Institute für Chirurgische Forschung, Ludwig-Maximilians-Universität, München, Germany

    A. Baethmann

  3. Department of Neurosurgery, Polish Academy of Scienes, Warsaw, Poland

    Z. Czernicki

  4. Section of Neurosurgery, University of Michigan, Ann Arbor, USA

    J. T. Hoff

  5. Department of Neurosurgery, Musashino Red Cross Hospital, Tokyo, Japan

    U. Ito

  6. Department of Neurological Surgery, Nihon University, Tokyo, Japan

    Y. Katayama

  7. Medical College of Virgina, Richmond, USA

    A. Marmarou

  8. Department of Neurosurgery, Newcastle Gerneral Hospital, Newcastle-upon-Tyne, UK

    B. A. D. Mendelow

  9. Neurochirurgische Universitätklinik, Ludwig-Maximilians-Universität, München, Germany

    H.-J. Reulen

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer-Verlag Wien

About this paper

Cite this paper

Otani, N., Nawashiro, H., Tsuzuki, N., Katoh, H., Miyazawa, T., Shima, K. (2003). Mitogen-activated protein kinases phosphorylation in posttraumatic selective vulnerability in rats. In: Kuroiwa, T., et al. Brain Edema XII. Acta Neurochirurgica Supplements, vol 86. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0651-8_62

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-0651-8_62

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-7220-9

  • Online ISBN: 978-3-7091-0651-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation