Skip to main content
SpringerLink
Log in

Verabreichung von parenteralen und oralen Tumortherapien

  • Chapter
  • First Online:
Onkologische Krankenpflege

  • 200 Accesses

Zusammenfassung

Die Verabreichung von intravenösen Therapien ist eine zentrale Aufgabe von onkologischen Pflegefachpersonen. Sie sorgen für einen sicheren venösen Zugang zur Vermeidung von Paravasaten, verfügen über fundiertes Fachwissen zu Onkologika, deren mögliche akute Infusionsreaktionen sowie das gewebstoxische Potenzial des Medikaments und wenden die nötigen Sicherheitsmaßnahmen im Umgang mit Zytostatika an. Ein wachsender Anteil an onkologisch wirksamen Medikamenten ist in Tablettenform verfügbar. Zunehmend übernehmen Pflegefachpersonen auch Aufgaben in der Betreuung von Krebsbetroffenen mit ausschließlich oralen Therapien. Eine auf die Person abgestimmte individuelle Patientenedukation über Medikament, Einnahme und Wirkung sowie die Abgabe von schriftlichem Informationsmaterial kann die Adhärenz zur oralen Therapie verbessern.

Autorin der vorherigen Fassung: A. Margulies

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 59.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 74.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Literatur

Zitierte Quellen

  • Atkins L, Fallowfield L (2006) Intentional and non-intentional non-adherence to medication amongst breast cancer patients. Eur J Cancer 42:2271–2276

    Article  PubMed  Google Scholar 

  • Bedell CH, Hartigan KJ, Wilkinson KI, Halpern IM (2002) Oral chemotherapy: progress with challenges. Hematol Oncol News Issues 1(9):28–32

    Google Scholar 

  • Burris HA, Hurtig J (2010) Radiation recall with anticancer agents. Oncologist 15(11):1227–1237

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Conde-Estévez D, Mateu-de Antonio J (2014) Treatment of anthracycline extravasations using dexrazoxane. Clin Transl Oncol 16:11–17

    Article  PubMed  Google Scholar 

  • Cortelezzi AN, Moia M, Falanga A, Pogliani EM, Agnelli G, Bonizzoni E et al (2005) CATHEM Study Group. Incidence of thrombotic complications in patients with haematological malignancies with central venous catheters: a prospective multicentre study. Br J Haematol 129:811–817

    Article  PubMed  Google Scholar 

  • Coyle CE, Griffie J, Czaplewski LM (2014) Eliminating extravasation events: a multidisciplinary approach. Art Sci Infus Nurs 37(3):157–164

    Article  Google Scholar 

  • De Wit M, Ortner P, Lipp H-P, Sehouli J, Untch M, Ruhnke M et al (2013) Management of cytotoxic extravasation – ASORS expert opinion for diagnosis, prevention and treatment. Onkologie 36:127–135

    PubMed  Google Scholar 

  • Fehm T, Marme A, Lipp HP, Schumacher K (2008) Paravasation von Zytostatika. Gynakologe 41:607–612

    Article  Google Scholar 

  • Filipe Monteiro A, Rato M, Martins C (2016) Drug-induced photosensitivity: photoallergic and phototoxic reactions. Clin Dermatol 34:571–581

    Article  Google Scholar 

  • Froiland K (2007) Extravasation injuries: implications für WOC nursing. Wound Ostomy Continence Nurs 34:299–302

    Article  Google Scholar 

  • Gnädinger M, Widmer C, Schöbi B, Stoll H, Schnider T, Huber A (2013a) Die peripher venöse Punktion. Teil 1: Die diagnostische Venenpunktion. Swiss Med Forum 13(4):70–74

    Article  Google Scholar 

  • Haslik W, Hacker S, Felberbauer FX, Thallinger C, Bartsch R, Kornaut C et al (2015) Port-a-Cath extravasation of vesicant cytotoxies: surgical options for a rare complication of cancer chemotherapy. Eur J Surg Oncol 41:378–385

    Article  CAS  PubMed  Google Scholar 

  • Hede K (2009) Increase in oral cancer drugs raises thorny issues for oncology practices. J Natl Cancer Inst 101(22):1534–1536

    Article  PubMed  Google Scholar 

  • Jordan K, Grothe W, Schmoll HJ (2005) Paravasation von Zytostatika: Prävention und Therapie. Dtsch Med Wochenschr 130:33–37

    Article  CAS  PubMed  Google Scholar 

  • Kav S, Schulmeister L, Nirenberg A, Barber L, Johnson J, Rittenberg C (2009) Development of the MASCC teaching tool for patients receiving oral agents for cancer. Support Care Cancer 18:583–590

    Article  PubMed  Google Scholar 

  • Khan DA (2016) Hypersensitivity and immunologic reactions to biologics: opportunities for the allergist. Ann Allergy Asthma Immunol 117:115–120

    Article  CAS  PubMed  Google Scholar 

  • Lehmann AD, Howard A, Mancini R (2019) Chemotherapy administration sequencing: an update on the current literature. J Hematol Oncol Pharmacy 9(4):175–181

    Google Scholar 

  • Leitlinienprogramm Onkologie (2016) S3-Leitlinie Supportive Therapie. Kapitel 11: Paravasate, 326–347

    Google Scholar 

  • Mader I, Fürst-Weger P, Mader RM, Nogler-Semenitz E, Wassertheurer S (2006) Paravasation von Zytostatika: Kompendium für Prävention und Therapie, 2. Aufl. Springer, Wien/New York

    Google Scholar 

  • Mancini R, Modlin J (2011) Chemotherapy administration sequence: a review of the literature and creation of a sequencing chart. J Hematol Oncol Pharmacy 1(1):17–25

    Google Scholar 

  • Manigold T (2013) Biologika – Genese und Charakteristika immunvermittelter Nebenwirkungen. Allergologie 36(10):452

    Article  Google Scholar 

  • Osterberg L, Blaschke T (2005) Adherence to medication. N Engl J Med 353:487–497

    Article  CAS  PubMed  Google Scholar 

  • Pérez Fidalgo J, Garcìa Fabregat L, Cervantes A, Margulies A, Vidall C, Roila F (2012) Management of chemotherapy extravasation: ESMO – EONS clinical practice guidelines. Eur J Oncol Nurs 16:528–534

    Article  PubMed  Google Scholar 

  • Pluschnig U, Haslik W, Bayer G, Soleiman A, Bartsch R, Lamm W et al (2015) Outcome of chemotherapy extravasation in a large patient series using a standardised management protocol. Support Care Cancer 23(6):1741–1748

    Article  PubMed  Google Scholar 

  • Ruddy K, Mayer E, Partridge A (2009) Patient adherence and persistence with oral anticancer treatment. CA Cancer J Clin 59:56–66

    Article  PubMed  Google Scholar 

  • Sachs B, Merk HF (2018) Akute Überempfindlichkeitsreaktionen auf monoklonale Antikörper zur zielgerichteten Therapie. Hautarzt 69:268–277

    Article  CAS  PubMed  Google Scholar 

  • Sakaida E, Sekine I, Iwasawa S, Kurimoto R, Uehare T, Ooka Y et al (2014) Incidence, risk factors and treatment outcomes of extravasation of cytotoxic agents in an outpatient chemotherapy clinic. Jpn J Clin Oncol 44(2):168–171

    Article  PubMed  Google Scholar 

  • Silva AA, Carlotto J, Rotta I (2018) Standardization of the infusion sequence of antineoplastic drugs used in the treatment of breast and colorectal cancer. Einstein 16(2):1–9

    Article  Google Scholar 

  • Steiert A, Hille U, Burke W, Gohritz A, Zilz S, Herold C et al (2010) Subcutaneous wash out procedure (SWOP) for the treatment of chemotherapeutic extravasations. J Plast Reconstr Aesthet Surg 64:240–247

    Article  PubMed  Google Scholar 

  • Weingart SN, Brown E, Bach PB, Eng K, Johnson SA, Kuzel TM et al (2008) NCCN task force report: oral chemotherapy. J Natl Compr Canc Netw 6(Suppl 3):S4–S14

    Google Scholar 

  • World Health Organisation [WHO] (2003) Adherence to long-term therapies: evidence for action. WHO, Geneva

    Google Scholar 

Weiterführende Literatur

  • Bedell CH (2003) A changing paradigm for cancer treatment: the advent of new oral chemotherapy agents. Clin J Oncol Nurs 7(6 Suppl):5–9

    Article  PubMed  Google Scholar 

  • Beers AM (2010) Safer vesicant administration: improving communication across provider lines. Clin J Oncol Nurs 14(2):234–236

    Article  PubMed  Google Scholar 

  • Boulanger J, Ducharme A, Dufour A, Fortier S, Almanric K (2015) Management of the extravasation of anti-neoplastic agents. Support Care Cancer 23:1459–1471

    Article  CAS  PubMed  Google Scholar 

  • Bozkurt KA, Uzel B, Akman C, Özgüroglu M, Mandel NM (2003) Intrathoracic extravasation of antineoplastic agents. Am J Clin Oncol 26(2):121–123

    Article  PubMed  Google Scholar 

  • De Wit M (2009) Zytostatika-Paravasate – ein seltenes Ereignis? Der Onkologe 15:169–172

    Article  Google Scholar 

  • Ener RA, Meglathery SB, Styler M (2004) Extravasation of systemic hemato-oncological therapies. Ann Oncol 15(6):858–862

    Article  CAS  PubMed  Google Scholar 

  • Gnädinger M, Widmer C, Schöbi B, Stoll H, Schnider T, Huber A (2013b) Die peripher venöse Punktion. Teil 2: Die therapeutische Venenpunktion. Swiss Med Forum 13(5):94–96

    Article  Google Scholar 

  • Hartigan K (2003) Patient education: the cornerstone of successful oral chemotherapy treatment. Clin J Oncol Nurs 7(6 Suppl):21–24

    Article  PubMed  Google Scholar 

  • Jordan K, Feyer P, Höller U, Link H, Wörmann B, Jahn F (2017) Clinical practice guideline: supportive treatments for patients with cancer. Dtsch Arztebl Int 114:481–487

    PubMed  PubMed Central  Google Scholar 

  • Jost M, Rüegger M, Liechti B, Gutzwiller A (2011) Sicherer Umgang mit Zytostatika. Schweizerische Unfallversicherungsanstalt [SUVA], 8., überarb. Aufl. SUVA, Abteilung Arbeitsmedizin, Luzern

    Google Scholar 

  • Kimmel J, Fleming P, Cuellar S, Anderson J, Mactal Haaf C (2018) Pharmacological management of anticancer agent extravasation: a single institutional guideline. J Oncol Pharm Pract 24(2):129–138

    Article  CAS  PubMed  Google Scholar 

  • Kopp B, Schierl R, Nowak D (2012) Evaluation of working practices and surface contamination with antineoplastic drugs in outpatient oncology health care settings. Int Arch Occup Environ Health 86:47–55

    Article  PubMed  Google Scholar 

  • Kroner T, Margulies A, Taverna C, Studer C (2013) Medikamente in der Tumortherapie, 4. Aufl. Springer, Berlin/Heidelberg

    Book  Google Scholar 

  • Moore S (2010) Nonadherence in patients with breast cancer receiving oral therapies. Clin J Oncol Nurs 14(1):41–47

    Article  PubMed  Google Scholar 

  • Nogler-Semenitz E, Mader I, Fürst-Weger P, Terkola R, Wassertheurer S, Giovanoli P et al (2004) Paravasation von Zytostatika. Wien Klin Wochenschr 116(9–10):289–295

    Article  PubMed  Google Scholar 

  • Palmieri FM, Barton DL (2007) Challenges of oral medications in patients with advanced breast cancer. Semin Oncol Nurs 23(4, Suppl 2):S17–S22

    Article  PubMed  Google Scholar 

  • Platzbecker U, Aul C, Ehninger G, Giagounidis A (2009) Reduction of 5-azacitidine induced skin reactions in MDS patients with evening primrose oil. Ann Hematol, published online

    Google Scholar 

  • Quintanar Verduguez T, Jarava AB, Martinez-Barbeito MB, Mendez CP, Gomez LL, Santiago JA et al (2008) Mediastinal extravasation of doxorubicin. Clin Transl Oncol 10:128–130

    Article  PubMed  Google Scholar 

  • Schulmeister L (2011) Extravasation management: clinical update. Semin Oncol Nurs 27(1):82–90

    Article  PubMed  Google Scholar 

  • Thakur JS, Chauhan CG, Diwana VK, Chauhan DC, Thakur A (2008) Extravasational side effects of cytostatic drugs: a preventable catastrophe. Indian J Plast Surg 41(2):145–150

    Article  PubMed  PubMed Central  Google Scholar 

  • Vidall C, Roe H, Dougherty L, Harrold K (2013) Dexrazoxane: a management option for anthracycline extravasation. Br J Nurs 22(17):S6–S12

    Article  PubMed  Google Scholar 

Internetadressen

Download references

Author information

Authors and Affiliations

  1. Kantonsspital Glarus AG, Glarus, Schweiz

    Anja Kröner & Christina Züger

Authors
  1. Anja Kröner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Christina Züger
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Anja Kröner .

Editor information

Editors and Affiliations

  1. Leiter Pflegeforschung & Entwicklung, Universitätsklinikum Halle AöR, Halle (Saale), Sachsen-Anhalt, Deutschland

    Patrick Jahn

  2. Krebsinformationsdienst, Deutsches Krebsforschungszentrum, Heidelberg, Deutschland

    Andrea Gaisser

  3. Hochschule für Gesundheit Freiburg, Fribourg, Schweiz

    Marika Bana

  4. OnkoZentrum Hirslanden, Universität Basel, Zürich, Zürich, Schweiz

    Christoph Renner

Rights and permissions

Reprints and permissions

Copyright information

© 2024 Der/die Autor(en), exklusiv lizenziert an Springer-Verlag GmbH, DE, ein Teil von Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Kröner, A., Züger, C. (2024). Verabreichung von parenteralen und oralen Tumortherapien. In: Jahn, P., Gaisser, A., Bana, M., Renner, C. (eds) Onkologische Krankenpflege. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-67417-8_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-67417-8_11

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-67416-1

  • Online ISBN: 978-3-662-67417-8

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation